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Benzyl Cinnamate


  • Brand : BIOFRON

  • Catalogue Number : BD-P0291

  • Specification : 98.0%(HPLC)

  • CAS number : 103-41-3

  • Formula : C16H14O2

  • Molecular Weight : 238.286

  • Volume : 100mg

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Catalogue Number


Analysis Method






Molecular Weight



Botanical Source

Structure Type

Simple Phenylpropanoids








1.1±0.1 g/cm3


Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

225.7±10.4 °C

Boiling Point

195-200 ºC (5 mmHg)

Melting Point

34-37 °C(lit.)



InChl Key


WGK Germany


HS Code Reference


Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:103-41-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.




RIFM fragrance ingredient safety assessment, benzyl cinnamate, CAS Registry Number 103-41-3


A M Api 1, D Belsito 2, S Biserta 1, D Botelho 1, M Bruze 3, G A Burton Jr 4, J Buschmann 5, M A Cancellieri 1, M L Dagli 6, M Date 1, W Dekant 7, C Deodhar 1, A D Fryer 8, S Gadhia 1, L Jones 1, K Joshi 1, A Lapczynski 1, M Lavelle 1, D C Liebler 9, M Na 1, D O'Brien 1, A Patel 1, T M Penning 10, G Ritacco 1, F Rodriguez-Ropero 1, J Romine 1, N Sadekar 1, D Salvito 1, T W Schultz 11, F Siddiqi 1, I G Sipes 12, G Sullivan 13, Y Thakkar 1, Y Tokura 14, S Tsang 1

Publish date

2020 Jul 15




The room temperature reaction of a 1 : 1 mixture of phosphorus tribromide (PBr3) and the N-heterocyclic carbene 1,3-bis(2,6-diisopropylphenyl)-imidazol-2-ylidene (IPr) quantitatively affords the Lewis acid-base adduct (IPr)PBr3 (1). Interestingly, when 1 is heated between 55 and 65 °C for a period of several days, dark red crystals slowly begin to form in the reaction vessel accompanied by the release of bromine. The resulting crystalline sample, [P2(IPr)2Br3]Br ([2]Br), results from the reductive coupling of two equivalents of 1, and contains a cationic moiety with a P-P bond that is bridged by a bromine atom. Anion exchange reactions with Na[BArF 4] (BArF 4 = B(3,5-{CF3}2C6H3)4) afford [2][BArF 4]. Abstraction of two equivalents of bromine allows for the isolation of the unprecedented dicationic species [P2(IPr)2Br2]2+ (3) which was isolated and structurally authenticated as two different [BArF 4]- salts. Reaction of 2 with mild reductants such as SnBr2 or tetrakis(dimethylamino)ethylene (TDAE) affords [P2(IPr)2Br]+ (4) and the known radical cation [P2(IPr)2]˙+ (5), respectively. These studies show that relatively weak P-Br bonds present in compounds 1-4 can be cleaved in a straightforward manner to afford low oxidation state compounds in high yields.


N-heterocyclic carbene induced reductive coupling of phosphorus tribromide. Isolation of a bromine bridged P-P bond and its subsequent reactivity†


Jordan B. Waters,a Thomas A. Everitt,a William K. Myers,a and Jose M. Goicoecheacorresponding authora

Publish date

2016 Dec 1;




The Chinese medicinal plant Artemisia annua L. (Qinghao) is the only known source of the sesquiterpene artemisinin (Qinghaosu), which is used in the treatment of malaria. Artemisinin is a highly oxygenated sesquiterpene, containing a unique 1,2,4-trioxane ring structure, which is responsible for the antimalarial activity of this natural product. The phytochemistry of A. annua is dominated by both sesquiterpenoids and flavonoids, as is the case for many other plants in the Asteraceae family. However, A. annua is distinguished from the other members of the family both by the very large number of natural products which have been characterised to date (almost six hundred in total, including around fifty amorphane and cadinane sesquiterpenes), and by the highly oxygenated nature of many of the terpenoidal secondary metabolites. In addition, this species also contains an unusually large number of terpene allylic hydroperoxides and endoperoxides. This observation forms the basis of a proposal that the biogenesis of many of the highly oxygenated terpene metabolites from A. annua – including artemisinin itself – may proceed by spontaneous oxidation reactions of terpene precursors, which involve these highly reactive allyllic hydroperoxides as intermediates. Although several studies of the biosynthesis of artemisinin have been reported in the literature from the 1980s and early 1990s, the collective results from these studies were rather confusing because they implied that an unfeasibly large number of different sesquiterpenes could all function as direct precursors to artemisinin (and some of the experiments also appeared to contradict one another). As a result, the complete biosynthetic pathway to artemisinin could not be stated conclusively at the time. Fortunately, studies which have been published in the last decade are now providing a clearer picture of the biosynthetic pathways in A. annua. By synthesising some of the sesquiterpene natural products which have been proposed as biogenetic precursors to artemisinin in such a way that they incorporate a stable isotopic label, and then feeding these precursors to intact A. annua plants, it has now been possible to demonstrate that dihydroartemisinic acid is a late-stage precursor to artemisinin and that the closely related secondary metabolite, artemisinic acid, is not (this approach differs from all the previous studies, which used radio-isotopically labelled precursors that were fed to a plant homogenate or a cell-free preparation). Quite remarkably, feeding experiments with labeled dihydroartemisinic acid and artemisinic acid have resulted in incorporation of label into roughly half of all the amorphane and cadinane sesquiterpenes which were already known from phytochemical studies of A. annua. These findings strongly support the hypothesis that many of the highly oxygenated sesquiterpenoids from this species arise by oxidation reactions involving allylic hydroperoxides, which seem to be such a defining feature of the chemistry of A. annua. In the particular case of artemisinin, these in vivo results are also supported by in vitro studies, demonstrating explicitly that the biosynthesis of artemisinin proceeds via the tertiary allylic hydroperoxide, which is derived from oxidation of dihydroartemisinic acid. There is some evidence that the autoxidation of dihydroartemisinic acid to this tertiary allylic hydroperoxide is a non-enzymatic process within the plant, requiring only the presence of light; and, furthermore, that the series of spontaneous rearrangement reactions which then convert this allylic hydroperoxide to the 1,2,4-trioxane ring of artemisinin are also non-enzymatic in nature.


artemisinin, dihydroartemisinic acid, sesquiterpene, biosynthesis, Artemisia annua, phytochemistry, oxidation, allylic hydroperoxide


The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)


Geoffrey D. Brown

Publish date

2010 Nov;