herb of Coptis chinensis Franch.
9,10-Dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium hydrogen sulfate/Berberine sulfate (1:1)/9,10-Dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium hydrogen sulfate/Berberine hydrogen sulfate/Berberine sulfate (VAN)/Acid berberine sulfate/Siarczanu berberyny [Polish]/berberine hemisulfate/Berberine hydrogen sulphate/BERBERINE SULFATE
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
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For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:633-66-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Osteoporosis, a metabolic bone disease, is characterized by an excessive formation and activation of osteoclasts. Anti-catabolic treatment using natural compounds has been proposed as a potential therapeutic strategy against the osteoclast related osteolytic diseases. In this study, the activity of berberine sulfate (an orally available form of berberine) on osteoclast differentiation and its underlying molecular mechanisms of action were investigated. Using bone marrow macrophages (BMMs) derived osteoclast culture system, we showed that berberine sulfate at the dose of 0.25, 0.5 and 1 μM significantly inhibited the formation of osteoclasts. Notably, berberine sulfate at these doses did not affect the BMM viability. In addition, we observed that berberine sulfate inhibited the expression of osteoclast marker genes, including cathepsin K (Ctsk), nuclear factor of activated T cells cytoplasmic 1 (NFATc1), tartrate resistant acid phosphatase (TRAcP, Acp5) and Vacuolar-type H+-ATPase V0 subunit D2 (V-ATPase d2). Luciferase reporter gene assay and Western blot analysis further revealed that berberine sulfate inhibits receptor for activation of nuclear factor ligand (RANKL)-induced NF-κB and NFAT activity. Taken together, our results suggest that berberinesulfate is a natural compound potentially useful for the treatment of osteoporosis.
NF-κB and NFAT pathway; RANKL; berberine sulfate; osteoclast
Berberine Sulfate Attenuates Osteoclast Differentiation through RANKL Induced NF-κB and NFAT Pathways.
Zhou L1, Song F2,3,4, Liu Q5,6,7, Yang M8, Zhao J9,10, Tan R11, Xu J12, Zhang G13, Quinn JM14, Tickner J15, Xu J16,17.
2015 Nov 13
The effect of berberin sulfate (single and chronic administration during 30 days in doses of 0.14-80 mg/kg) on the functional state of hemostasis system was studied on gamma-irradiated (dose 5.0 Gy) and intact Wistar rats and mice (CBA x C57BL)F1. Administration of the drug increases the number of thrombocytes, decreases the activity of factor XIII and promote blood coagulation.
[Modification to the functional status of the hemostatic system with the use of berberine sulfate].
Ziablitskiĭ VM, Romanovskaia VN, Umurzakova RZ, Starosel'skaia AN, Mikhal'skaia TIu.
Berberine sulfate is a natural alkaline, reduces apoptosis, with potent anti-oxidative and anti-inflammatory effect.