White crystalline powder
Eriobotrya japonica,Ligustrum lucidum,Mentha canadensis,Paeonia suffruticosa,Spatholobus suberectus
(3β)-3-Hydroxylup-20(29)-en-28-oic acid/Gratiolone/(1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-Hydroxy-1-isopropenyl-5a,5b,8,8,11a-pentamethylicosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylic acid/betulic acid/Platanol/3β-Hydroxy-20(29)-lupaene-28-oic Acid/(3b)-3-hydroxylup-20(29)-en-28-oic Acid/Lup-20(29)-en-28-oic acid, 3β-hydroxy-/Betulinic acid/MAIRIN/Lup-20(29)-en-28-oic acid, 3-hydroxy-, (3β)-/Melaleucin/ALS-357/Betulinic
550.0±33.0 °C at 760 mmHg
295-298 °C (dec.)(lit.)
HS Code Reference
Personal Projective Equipment
For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:472-15-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Betulinic acid is a naturally occurring pentacyclic lupane-type triterpenoid usually isolated from birch trees, but present in many other botanical sources. It is found in different plant organs, both as a free aglycon and as glycosyl derivatives. A wide range of pharmacological activities has been described for this triterpenoid, including antiviral and antitumor effects. In addition, several other interesting properties have been identified in the fields of immunity and metabolism, namely antidiabetic, antihyperlipidemic, and anti-inflammatory activities. Taken together, these latter three properties make betulinic acid a highly interesting prospect for treating metabolic syndrome. The present review focuses on the therapeutic potential of this agent, along with several of its semisynthetic derivatives, which could open new frontiers in the use of natural product-based medicines.
Georg Thieme Verlag KG Stuttgart · New York.
New Pharmacological Opportunities for Betulinic Acid
Jose Luis Rios 1 , Salvador MaNez 1
Betulinic acid (BA), a pentacyclic triterpene of natural origin, has been demonstrated to have varied biologic activities including anti-viral, anti-inflammatory, and anti-malarial effects; it has also been found to induce apoptosis in many types of cancer. However, little is known about the effect of BA on normal cells. In this study, the effects of BA on normal neuronal cell apoptosis and the mechanisms involved were studied using differentiated PC12 cells as a model. Treatment with 50 μM BA for 24 h apparently induced PC12 cell apoptosis. In the early stage of apoptosis, the level of intracellular reactive oxygen species (ROS) increased. Afterwards, the loss of the mitochondrial membrane potential, the release of cytochrome c and the activation of caspase-3 occurred. Treatment with antioxidants could significantly reduce BA-induced PC12 cell apoptosis. In conclusion, we report for the first time that BA induced the mitochondrial apoptotic pathway in differentiated PC12 cells through ROS.
Betulinic Acid Induces Apoptosis in Differentiated PC12 Cells Via ROS-Mediated Mitochondrial Pathway
Xi Wang 1 , Xiaocheng Lu 2 , Ronglan Zhu 3 , Kaixin Zhang 1 4 , Shuai Li 1 , Zhongjun Chen 1 5 , Lixin Li 6
Betulinic acid (BA), a naturally occurring plant-derived pentacyclic triterpenoid, has gained attention in recent years owing to its broad-spectrum biological and medicinal properties. Despite the pharmacological activity of BA, it has been associated with some drawbacks, such as poor aqueous solubility and short half-life in vivo, which limit therapeutic application. To solve these problems, much work in recent years has focused on enhancing BA’s aqueous solubility, half-life, and efficacy by using nanoscale drug delivery systems. Several different kinds of nanoscale delivery systems-including polymeric nanoparticles, magnetic nanoparticles, liposomes, polymeric conjugates, nanoemulsions, cyclodextrin complexes, and carbon nanotubes-have been developed for the delivery of BA. Here, we focus on the recent developments of novel nanoformulations used to deliver BA in order to improve its efficacy.
betulinic acid; cancer; drug delivery; liposomes; nanoparticles.
Therapeutic Applications of Betulinic Acid Nanoformulations
Ankit Saneja 1 2 3 , Divya Arora 2 3 , Robin Kumar 1 , Ravindra Dhar Dubey 2 , Amulya K Panda 1 , Prem N Gupta 2 3
Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties.