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Borneol

Brand : BIOFRON
Catalogue Number : BN-O0005
Specification : 98%(HPLC)
CAS number : 507-70-0
Formula : C10H18O
Molecular Weight : 154.25
PUBCHEM ID : 64685
Volume : 20mg

Catalogue Number

BN-O0005

Analysis Method

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

154.25

Appearance

Oil

Botanical Source

This product is isolated and purified from the branch of Cinnamomum camphora (L) presl.

Structure Type

Category

SMILES

CC1(C2CCC1(C(C2)O)C)C

Synonyms

Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, (1R,2S,4R)-/exo-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol/2-Hydroxybornane/Borneol/bornyl alcohol/Baros camphor/methyl isobornyl ether/endo-borneol/(1R,2S,4R)-(+)-Borneol/(+)-Bornyl alcohol/isobornyl alcohol/(1R,2S,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol/(1R,2S,4R)-rel-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol/Bhimsaim campho/d-borneol/2-Hydroxycamphane/Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-/1,7,7-Trimethylbicyclo(2.2.1)heptan-2-ol/Dryobalanops camphor/Bicyclo(2.2.1)heptan-2-ol, 1,7,7-trimethyl-/1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol/Borneo camphor/(1R,2S,4R)-borneol/(1R-endo)-1,7,7-Trimethylbicyclo(2.2.1)heptan-2-ol/Camphol/Camphane, 2-hydroxy-/Malayan camphor

IUPAC Name

Density

1.011

Solubility

Flash Point

65 ºC

Boiling Point

212.0±0.0 °C at 760 mmHg

Melting Point

206-207ºC

InChl

InChl Key

DTGKSKDOIYIVQL-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:507-70-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

31635731

Abstract

Antimicrobial modifications of chitosan usually endow the products with strong bactericidal activities. However, if the products come into direct contact with human skin, the skin flora, which is beneficial to human health, may be damaged. To address this issue, we developed a stereochemical antimicrobial strategy by grafting borneol 4-formylbenzoate to chitosan using a stable Schiff base bond; this process yielded borneol-modified chitosan (BMC) as a novel antimicrobial material. This material was challenged with gram-negative Escherichia coli, gram-positive Bacillus subtilis, and Aspergillus niger. All tests showed excellent antimicrobial adhesive properties. Guinea pig skin experiments further demonstrated that BMC did not damage the skin flora. Owing to the antimicrobial mechanism of borneol stereochemistry, BMC successfully defended against pathogens and protected the skin flora. Thus, this material may have excellent potential applications in multifunctional textiles, healthcare, and flexible skin electronics.

Copyright © 2019 Elsevier Ltd. All rights reserved.

KEYWORDS

Antimicrobial adhesion; Borneol; Chitosan; Skin flora; Stereochemistry

Title

Borneol-modified chitosan: Antimicrobial adhesion properties and application in skin flora protection.

Author

Xin Y1, Zhao H2, Xu J3, Xie Z2, Li G2, Gan Z2, Wang X4.

Publish date

2020 Jan 15

PMID

31374355

Abstract

Doxorubicin (DOX) as a first-line chemotherapeutic drug has been widely used for therapy of human cancers. However, side effects and chemo-resistance severely blocked its clinic application. Herein, natural borneol (NB) as a novel monoterpenoid chemosensitizer was found to have the potential to increase the blood brain barrier (BBB) permeability and intracellular uptake of DOX in vitro, and synergistically enhanced DOX-induced cytotoxicity in human glioma cells. NB treatment significantly potentiated DOX-induced G2/M cell cycle arrest by triggering reactive oxygen species (ROS)-mediated DNA damage. NB also enhanced DOX-induced dysfunction of MAPKs and PI3 K/AKT pathways. Furthermore, U251 human glioma xenograft growth in vivo was also effectively inhibited by combined treatment of DOX with NB through induction of G2/M-phase arrest and antiangiogenesis. Taken together, our finding validated that NB could act as novel chemosensitizer to enhance DOX-induced anticancer efficacy, and strategy of using NB and DOX could be a high efficient way in therapy of human cancers.

Copyright © 2019 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

KEYWORDS

Chemosensitizer; DNA damage; Doxorubicin; Natural borneol; ROS

Title

Enhanced anticancer efficiency of doxorubicin against human glioma by natural borneol through triggering ROS-mediated signal.

Author

Cao WQ1, Li Y2, Hou YJ3, Yang MX4, Fu XQ5, Zhao BS4, Jiang HM6, Fu XY7.

Publish date

2019 Oct

PMID

31301416

Abstract

AIM:
Brain injury after sepsis leads to high mortality and long-term brain dysfunction in patients. Previous studies revealed that borneol has a protective effect on the brain, but its function on sepsis associated encephalopathy (SAE) remains unknown. Herein, we investigated the protective effect of borneol against sepsis-related brain injury.

MAIN METHODS:
Lipopolysaccharide (LPS)-induced sepsis mice and cells were treated with borneol at the dose of 100 mg/kg by gavage or 10 μg/ml in culture, respectively. The protective effect of borneol on neurons and the microglia were assessed in vivo and in vitro.

KEY FINDINGS:
We observed that borneol attenuated brain neuronal and microglial inflammation in LPS-induced sepsis mice with a suppression of p-p65 and p38 signaling that were initially activated by LPS in the brain. In vitro examination confirmed that the protective effect of borneol on both neurons and microglia, and its suppressive effect on p-p65 and p38 pathways were, at least in part, direct.

SIGNIFICANCE:
An early protection of neurons and microglia from bacterial endotoxin during sepsis is beneficial, and borneol has the potential to protect these cells.

Copyright © 2019. Published by Elsevier Inc.

KEYWORDS

Borneol; MAPK signaling; Neuroinflammation; Neuroprotection; Sepsis

Title

Borneol alleviates brain injury in sepsis mice by blocking neuronal effect of endotoxin.

Author

Wang L1, Liang Q1, Lin A1, Wu Y1, Min H1, Song S1, Wang Y1, Wang H1, Yi L1, Gao Q2.

Publish date

2019 Sep 1