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Broussonin A

$1,216

Brand : BIOFRON
Catalogue Number : BN-B1503
Specification : 98%(HPLC)
CAS number : 73731-87-0
Formula : C16H18O3
Molecular Weight : 258.32
PUBCHEM ID : 5315502
Volume : 5mg

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Catalogue Number

BN-B1503

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

258.32

Appearance

Powder

Botanical Source

This product is isolated and purified from the branch of Broussonetia papyrifera

Structure Type

Phenols

Category

Standards;Natural Pytochemical;API

SMILES

COC1=CC(=C(C=C1)CCCC2=CC=C(C=C2)O)O

Synonyms

2-[3-(4-Hydroxyphenyl)propyl]-5-methoxyphenol/Phenol, 2-[3-(4-hydroxyphenyl)propyl]-5-methoxy-

IUPAC Name

2-[3-(4-hydroxyphenyl)propyl]-5-methoxyphenol

Density

1.2±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

219.6±25.9 °C

Boiling Point

439.5±35.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C29H39NO7/c1-3-30-13-27(14-31)10-9-19(32)29-17-11-16-18(36-2)12-28(35,21(25(29)30)22(33)24(27)29)20(17)23(16)37-26(34)15-7-5-4-6-8-15/h4-8,16-25,31-33,35H,3,9-14H2,1-2H3/t16-,17-,18+,19+,20-,21?,22+,23+,24-,25-,27+,28-,29+/m1/s1

InChl Key

MSNVBURPCQDLEP-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2942000000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:73731-87-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

24827684

Abstract

Anemarrhena asphodeloides is widely used in traditional Chinese medicine, and is known to possess antidiabetic and anti-inflammatory properties. Because inducible nitric oxide synthase (iNOS) plays an important role in inflammation, we investigated the inhibitory effects of two known phenolic compounds, nyasol (1) and broussonin A (2), from A. asphodeloides, on iNOS and its plausible mechanism of action. Compounds 1 and 2 exhibited inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. Compounds 1 and 2 also suppressed the expressions of iNOS protein and mRNA. Moreover, compounds 1 and 2 suppressed the expression of inflammatory cytokines such as interleukin-1β (IL-1β) and interferon-β (IFN-β). They also inhibited the transcriptional activity of NF-κB and degradation of IκB-α, as well as the activation of Akt and ERK in LPS-stimulated RAW 264.7 cells. In in vivo animal model, compounds 1 and 2 significantly inhibited TPA-induced mouse ear edema. These results suggest that 1 and 2 suppress LPS-stimulated iNOS expression at the transcriptional level through modulating NF-κB and down-regulation of the Akt and ERK signaling pathways. Taken together, these findings indicate that the suppressive effects of 1 and 2 on iNOS expression might provide one possible mechanism for their anti-inflammatory activities.

Copyright © 2014 Verlag Helvetica Chimica Acta AG, Zurich.

KEYWORDS

Anti-inflammatory activity; Broussonin A; Inducible nitric oxide synthase (iNOS); NF-κB; Nyasol

Title

Suppression of inducible nitric oxide synthase expression by nyasol and broussonin A, two phenolic compounds from Anemarrhena asphodeloides, through NF-κB transcriptional regulation in vitro and in vivo.

Author

Jin Lee E1, Chung HJ, Pyee Y, Hong JY, Joung Youn U, Seo EK, Kook Lee S.

Publish date

2014 May