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Butylparaben

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-B3011

  • Specification : 98%

  • CAS number : 94-26-8

  • Formula : C11H14O3

  • Molecular Weight : 194.23

  • PUBCHEM ID : 7184

  • Volume : 100mg

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Catalogue Number

BF-B3011

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

194.23

Appearance

White crystalline powder

Botanical Source

Nelumbo nucifera and Strychnos cathayensis

Structure Type

Phenolics

Category

Standards;Natural Pytochemical;API

SMILES

CCCCOC(=O)C1=CC=C(C=C1)O

Synonyms

butyl para-hydroxybenzoate/butylbutex/n-Butyl-paraben/SPF/n-butyl-p-hydroxybenzoate/4-Hydroxybenzoic acid butyl ester/preservalb/p-Hydroxybenzoic acid, n-butyl ester/Lexgard B/Mekkings B/Butylparaben/n-butyl para-hydroxybenzoate/4-hydroxybenzoic acid-n-butyl ester/Nipabutyl/4-Hydroxybenzoic acid, butyl ester/Butyl p-hydroxybenzoate/butoben/Butyl Paraben/Benzoic acid, 4-hydroxy-, butyl ester/Butyl parasept/solbrolb/p-hydroxybenzoic acid n-butyl ester/p-Hydroxybenzoic acid, butyl ester/p-hydroxybenzoic acid butyl ester/Butyl 4-hydroxybenzoate/n-Butyl-4-hydroxybenzoate/Butyl Parahydroxybenzoate/n-butyl 4-hydroxybenzoate/p-Hydroxybenzoic butyl ester/4-Hydroxybenzoic acid n-butyl ester/Tegosept B/n-butylparaben/tegoseptb

IUPAC Name

butyl 4-hydroxybenzoate

Density

1.1±0.1 g/cm3

Solubility

Methanol; Ethyl Acetate; DMSO

Flash Point

129.2±13.2 °C

Boiling Point

309.2±15.0 °C at 760 mmHg

Melting Point

67-70 °C(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2918290000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:94-26-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

29460325

Abstract

The estrogenic and anti-estrogenic effects of butylparaben (BuPB), butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) and propyl gallate (PG) were evaluated for individual compounds as well as for binary mixtures, using an estrogen-dependent reporter gene assay in T47D-Kbluc breast cancer cells and an estrogen-dependent proliferation assay in MCF-7 breast cancer cells. In terms of estrogenicity the potency of the selected compounds increased from BHA < PG < BuPB in the luciferase assay (with BHT showing no significant estrogenic activity), while in the proliferation assay the following order was observed: BHT < BHA < BuPB (with PG showing no significant estrogenic activity). Non-monotonic dose-response curves were obtained for BuPB (in both assays) and PG (in the luciferase assay), respectively. In the presence of estradiol, a significant anti-estrogenic activity was observed in both cell lines for PG, BuPB and BHA, while BHT showed weak anti-estrogenic activity only in T47D-Kbluc cells. The evaluation of binary mixtures confirmed the endocrine disruptive potential of the compounds, their individual potency being correlated with that of the mixtures. All mixtures were able to reduce the estradiol-induced luminescence or cell proliferation, an effect that was accurately predicted by the dose addition mathematical model, suggesting the same (or at least partially overlapping) modes of action for the tested compounds. The results of the present study emphasize the importance of a cumulative risk assessment of endocrine disruptors.

Copyright © 2018 John Wiley & Sons, Ltd.

KEYWORDS

anti-estrogen; endocrine disruptor; estrogen; in vitro; luciferase; mixture; proliferation

Title

Estrogenic and anti-estrogenic activity of butylparaben, butylated hydroxyanisole, butylated hydroxytoluene and propyl gallate and their binary mixtures on two estrogen responsive cell lines (T47D-Kbluc, MCF-7).

Author

Pop A1, Drugan T2, Gutleb AC1,3, Lupu D1, Cherfan J1,4, Loghin F1, Kiss B1.

Publish date

2018 Jul

PMID

29516647

Abstract

BACKGROUND:
Butylparaben (butyl p-hydroxybenzoic acid) is a common cosmetic and pharmaceutical preservative reported to induce oxidative stress and endocrine disruption. Embryonic development is sensitive to oxidative stress, with redox potentials playing critical roles in progenitor cell fate decisions. Because pancreatic beta cells have been reported to have low antioxidant gene expression, they may be sensitive targets of oxidative stress. We tested the hypotheses that butylparaben causes oxidative stress in the developing embryo, and that pancreatic beta cells are a sensitive target of butylparaben embryotoxicity.

METHODS:
Transgenic insulin:GFP zebrafish embryos (Danio rerio) were treated daily with 0, 250, 500, 1,000, and 3,000 nM butylparaben. Pancreatic islet and whole embryo development were examined though 7 days postfertilization, and gene expression was measured by quantitative real-time PCR. Glutathione (GSH) and cysteine redox content were measured at 28 hr postfertilization using HPLC.

RESULTS:
Butylparaben exposure caused intestinal effusion, pericardial edema, and accelerated yolk utilization. At 250 nM, beta cell area increased by as much as 55%, and increased incidence of two aberrant morphologies were observed-fragmentation of the islet cluster and ectopic beta cells. Butylparaben concentrations of 500 and 1,000 nM increased GSH by 10 and 40%, respectively. Butylparaben exposure downregulated transcription factor pdx1, as well as genes involved in GSH synthesis, while upregulating GSH-disulfide reductase (gsr).

CONCLUSIONS:
The endocrine pancreas is a sensitive target of embryonic exposure to butylparaben, which also causes developmental deformities and perturbs redox conditions in the embryo.

© 2018 Wiley Periodicals, Inc.

KEYWORDS

developmental defects; developmental toxicology; endocrine; glutathione; oxidative stress; paraben; redox

Title

Pancreatic beta cells are a sensitive target of embryonic exposure to butylparaben in zebrafish (Danio rerio).

Author

Brown SE1, Sant KE1, Fleischman SM1, Venezia O1, Roy MA1,2, Zhao L3, Timme-Laragy AR1.

Publish date

2018 Jul 3

PMID

27122241

Abstract

Parabens comprise a group of preservatives commonly added to cosmetics, lotions, and other consumer products. Butylparaben has estrogenic and antiandrogenic properties and is known to reduce sperm counts in rats following perinatal exposure. Whether butylparaben exposure can affect other endocrine sensitive endpoints, however, remains largely unknown. In this study, time-mated Wistar rats (n = 18) were orally exposed to 0, 10, 100, or 500 mg/kg bw/d of butylparaben from gestation day 7 to pup day 22. Several endocrine-sensitive endpoints were adversely affected. In the 2 highest dose groups, the anogenital distance of newborn male and female offspring was significantly reduced, and in prepubertal females, ovary weights were reduced and mammary gland outgrowth was increased. In male offspring, sperm count was significantly reduced at all doses from 10 mg/kg bw/d. Testicular CYP19a1 (aromatase) expression was reduced in prepubertal, but not adult animals exposed to butylparaben. In adult testes, Nr5a1 expression was reduced at all doses, indicating persistent disruption of steroidogenesis. Prostate histology was altered at prepuberty and adult prostate weights were reduced in the high dose group. Thus, butylparaben exerted endocrine disrupting effects on both male and female offspring. The observed adverse developmental effect on sperm count at the lowest dose is highly relevant to risk assessment, as this is the lowest observed adverse effect level in a study on perinatal exposure to butylparaben.

© The Author 2016. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

KEYWORDS

breast; endocrine disruption; paraben; prostate; reproduction; sexual development; testis

Title

Multiple Endocrine Disrupting Effects in Rats Perinatally Exposed to Butylparaben.

Author

Boberg J1, Axelstad M2, Svingen T2, Mandrup K2, Christiansen S2, Vinggaard AM2, Hass U2.

Publish date

2016 Jul


Description :

Butylparaben is an organic compound, has proven to be a highly successful antimicrobial preservative in cosmetics, also used in medication suspensions, and as a flavoring additive in food.