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Caboxine A


  • Brand : BIOFRON

  • Catalogue Number : BN-O1565

  • Specification : 98%(HPLC)

  • CAS number : 53851-13-1

  • Formula : C22H26N2O5

  • Molecular Weight : 398.5

  • PUBCHEM ID : 91895272

  • Volume : 5mg

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Catalogue Number


Analysis Method






Molecular Weight




Botanical Source

This product is isolated and purified from the herbs of Catharanthus roseus

Structure Type



Standards;Natural Pytochemical;API




11-methoxy<5>metacyclophane/reserpinine oxindole/Spiro[3H-indole-3,6'(10'H)-[1H]pyrano[3,4-f]indolizine]-4'-carboxylic acid, 1,2,4'a,5',5'a,7',8',10'a-octahydro-6-methoxy-1'-methyl-2-oxo-,methyl/ester,(1'S,3S,4a'S,5a'S,10a'S)-/Hydroxyindolreserpinin/Methyl (7α,19α,20α)-11-methoxy-19-methyl-2-oxoformosanan-16-carboxylate


methyl (1S,4aS,5aS,6S,10aS)-6'-methoxy-1-methyl-2'-oxospiro[1,4a,5,5a,7,8,10,10a-octahydropyrano[3,4-f]indolizine-6,3'-1H-indole]-4-carboxylate


1.3±0.1 g/cm3


Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

303.6±30.1 °C

Boiling Point

578.4±50.0 °C at 760 mmHg

Melting Point



InChl Key


WGK Germany


HS Code Reference


Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:53851-13-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.




Food security relies on the resilience of staple food crops to climatic variability and extremes, but the climate resilience of European wheat is unknown. A diversity of responses to disturbance is considered a key determinant of resilience. The capacity of a sole crop genotype to perform well under climatic variability is limited; therefore, a set of cultivars with diverse responses to weather conditions critical to crop yield is required. Here, we show a decline in the response diversity of wheat in farmers’ fields in most European countries after 2002-2009 based on 101,000 cultivar yield observations. Similar responses to weather were identified in cultivar trials among central European countries and southern European countries. A response diversity hotspot appeared in the trials in Slovakia, while response diversity “deserts” were identified in Czechia and Germany and for durum wheat in southern Europe. Positive responses to abundant precipitation were lacking. This assessment suggests that current breeding programs and cultivar selection practices do not sufficiently prepare for climatic uncertainty and variability. Consequently, the demand for climate resilience of staple food crops such as wheat must be better articulated. Assessments and communication of response diversity enable collective learning across supply chains. Increased awareness could foster governance of resilience through research and breeding programs, incentives, and regulation.


wheat, cultivar, Europe, climate resilience, response diversity


Decline in climate resilience of European wheat


Helena Kahiluoto,a,1 Janne Kaseva,b Jan Balek,c,d Jørgen E. Olesen,e Margarita Ruiz-Ramos,f Anne Gobin,g Kurt Christian Kersebaum,h Jozef Takac,i Francoise Ruget,j Roberto Ferrise,k Pavol Bezak,i Gemma Capellades,l Camilla Dibari,k Hanna Makinen,a Claas Nendel,h Domenico Ventrella,m Alfredo Rodriguez,f,n Marco Bindi,k and Mirek Trnkac,d

Publish date

2019 Jan 2;




Peptide dendrimers, due to their biocompatibility and low toxicity, are highly promising candidates as nanocarriers for drugs and genes. The development of this kind of delivery system requires reliable monitoring of their metabolic and biological pathways. In this respect, hydrogen isotope labeling has tremendous importance, being a safe tool for detection of the labeled nanocarriers. In this work, we have synthesized new histidine-rich lysine-based dendrimers (Lys-2His dendrimer) with two linear histidine (His) residues in every inner segment. The presence of His residues has enabled us to perform controlled deuteration of Lys-2His dendrimers. The high deuteration degree (around 70%) does not practically change after redissolving the samples in H2O and heating them at 40 °C, which indicates the isotopic label stability.


peptide dendrimer, deuterium labeling, histidine


Stable Deuterium Labeling of Histidine-Rich Lysine-Based Dendrimers


Nadezhda N. Sheveleva,1 Denis A. Markelov,1,* Mikhail A. Vovk,1 Irina I. Tarasenko,2 Mariya E. Mikhailova,1 Maxim Yu Ilyash,3 Igor M. Neelov,3 and Erkki Lahderanta4

Publish date

2019 Jul




Resistivity, ρ(T), and magnetoresistance (MR) are investigated in the Cu2ZnSnxGe1−xS4 single crystals, obtained by the chemical vapor transport method, between x = 0-0.70, in the temperature range of T ~ 50-300 K in pulsed magnetic field of B up to 20 T. The Mott variable-range hopping (VRH) conductivity is observed within broad temperature intervals, lying inside that of T ~ 80-180 K for different x. The nearest-neighbor hopping conductivity and the charge transfer, connected to activation of holes into the delocalized states of the acceptor band, are identified above and below the Mott VRH conduction domain, respectively. The microscopic electronic parameters, including width of the acceptor band, the localization radius and the density of the localized states at the Fermi level, as well as the acceptor concentration and the critical concentration of the metal-insulator transition, are obtained with the analysis of the ρ(T) and MR data. All the parameters above exhibit extremums near x = 0.13, which are attributable mainly to the transition from the stannite crystal structure at x = 0 to the kesterite-like structure near x = 0.13. The detailed analysis of the activation energy in the low-temperature interval permitted estimations of contributions from different crystal phases of the border compounds into the alloy structure at different compositions.


Magnetotransport and conductivity mechanisms in Cu2ZnSnxGe1−xS4 single crystals


Erkki Lahderanta,1 Elena Hajdeu-Chicarosh,1,2 Maxim Guc,1,2 Mikhail A. Shakhov,1,3 Ivan Zakharchuk,1 Ivan V. Bodnar,4 Ernest Arushanov,2 and Konstantin G. Lisunovcorresponding author1,2

Publish date


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