We Offer Worldwide Shipping
Login Wishlist

Cabozantinib

$120

  • Brand : BIOFRON

  • Catalogue Number : BN-O1224

  • Specification : 98%(HPLC)

  • CAS number : 849217-68-1

  • Formula : C28H24FN3O5

  • Molecular Weight : 501.51

  • PUBCHEM ID : 25102847

  • Volume : 5mg

Available on backorder

Quantity
Checkout Bulk Order?

Catalogue Number

BN-O1224

Analysis Method

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

501.51

Appearance

Powder

Botanical Source

Structure Type

Category

SMILES

COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F

Synonyms

N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide/[14C]-Cabozantinib/Cometriq/N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide/cyclopropane-1,1-dicarboxylic acid [4-(6,7-dimethoxy-quinoline-4-yloxy)-phenyl]-amide (4-fluoro-phenyl)-amide/1,1-Cyclopropanedicarboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-/XL 184/N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide/Cabozantinib/1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide/N-{4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl}-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide/XL-184/XL184

IUPAC Name

Density

1.4±0.1 g/cm3

Solubility

Flash Point

412.3±32.9 °C

Boiling Point

758.1±60.0 °C at 760 mmHg

Melting Point

InChl

InChl Key

ONIQOQHATWINJY-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:849217-68-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

29999901

Title

Cabozantinib

Publish date

2018 Dec 3.

PMID

30926929

Abstract

Treatment of neuroepithelial cancers remains a daunting clinical challenge, particularly due to an inability to address rampant invasion deep into eloquent regions of the brain. Given the lack of access, and the dispersed nature of brain tumor cells, we explore the possibility of electric fields inducing directed tumor cell migration. In this study we investigate the properties of populations of brain cancer undergoing electrotaxis, a phenomenon whereby cells are directed to migrate under control of an electrical field. We investigate two cell lines for glioblastoma and medulloblastoma (U87mg & DAOY, respectively), plated as spheroidal aggregates in Matrigel-filled electrotaxis channels, and report opposing electrotactic responses. To further understand electrotactic migration of tumor cells, we performed RNA-sequencing for pathway discovery to identify signaling that is differentially affected by the exposure of direct-current electrical fields. Further, using selective pharmacological inhibition assays, focused on the PI3K/mTOR/AKT signaling axis, we validate whether there is a causal relationship to electrotaxis and these mechanisms of action. We find that U87 mg electrotaxis is abolished under pharmacological inhibition of PI3Kγ, mTOR, AKT and ErbB2 signaling, whereas DAOY cell electrotaxis was not attenuated by these or other pathways evaluated.

Title

Electrotaxis of Glioblastoma and Medulloblastoma Spheroidal Aggregates

Author

Johnathan G. Lyon,corresponding author1,2 Sheridan L. Carroll,1 Nassir Mokarram,1 and Ravi V. Bellamkondacorresponding author1

Publish date

2019

PMID

28327085

Abstract

Background
Corynebacterium pseudotuberculosis biovar ovis, a facultative intracellular pathogen, is the etiologic agent of caseous lymphadenitis in small ruminants. During the infection process, C. pseudotuberculosis changes its gene expression to resist different types of stresses and to evade the immune system of the host. However, factors contributing to the infectious process of this pathogen are still poorly documented. To better understand the C. pseudotuberculosis infection process and to identify potential factors which could be involved in its virulence, experimental infection was carried out in a murine model using the strain 1002_ovis and followed by a comparative proteomic analysis of the strain before and after passage.

Results
The experimental infection assays revealed that strain 1002_ovis exhibits low virulence potential. However, the strain recovered from the spleen of infected mice and used in a new infection challenge showed a dramatic change in its virulence potential. Label-free proteomic analysis of the culture supernatants of strain 1002_ovis before and after passage in mice revealed that 118 proteins were differentially expressed. The proteome exclusive to the recovered strain contained important virulence factors such as CP40 proteinase and phospholipase D exotoxin, the major virulence factor of C. pseudotuberculosis. Also, the proteome from recovered condition revealed different classes of proteins involved in detoxification processes, pathogenesis and export pathways, indicating the presence of distinct mechanisms that could contribute in the infectious process of this pathogen.

Conclusions
This study shows that C. pseudotuberculosis modifies its proteomic profile in the laboratory versus infection conditions and adapts to the host context during the infection process. The screening proteomic performed us enable identify known virulence factors, as well as potential proteins that could be related to virulence this pathogen. These results enhance our understanding of the factors that might influence in the virulence of C. pseudotuberculosis.

Electronic supplementary material
The online version of this article (doi:10.1186/s12866-017-0925-6) contains supplementary material, which is available to authorized users.

KEYWORDS

Corynebacterium pseudotuberculosis, Bacterial label-free proteomic, Caseous lymphadenitis, Bacterial virulence, Serial passage, Extracellular proteins

Title

A shift in the virulence potential of Corynebacterium pseudotuberculosis biovar ovis after passage in a murine host demonstrated through comparative proteomics

Author

Wanderson M. Silva,1,4,5 Fernanda A. Dorella,1 Siomar C. Soares,1 Gustavo H. M. F. Souza,3 Thiago L. P. Castro,1 Núbia Seyffert,1 Henrique Figueiredo,6 Anderson Miyoshi,1 Yves Le Loir,4,5 Artur Silva,2 and Vasco Azevedocorresponding author1

Publish date

2017


Description :

Empty ...