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Cabralealactone

$1,030

  • Brand : BIOFRON

  • Catalogue Number : AV-C10467

  • Specification : 98%

  • CAS number : 19865-87-3

  • Formula : C27H42O3

  • Molecular Weight : 414.6

  • PUBCHEM ID : 44421647

  • Volume : 5mg

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Catalogue Number

AV-C10467

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

414.6

Appearance

Powder

Botanical Source

Structure Type

Triterpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1(C2CCC3(C(C2(CCC1=O)C)CCC4C3(CCC4C5(CCC(=O)O5)C)C)C)C

Synonyms

(5α)-4,4,8,14-Tetramethyl-20,24-epoxy-18-norcholane-3,24-dione/Dipterocarpon/(5α,17β)-4,4,8,10,14-pentamethyl-17-[(2S)-2-methyl-5-oxotetrahydrofuran-2-yl]gonan-3-one/cabralelactone/Cabralealacton/Cabralealactone/Gonan-3-one, 4,4,8,10,14-pentamethyl-17-[(2S)-tetrahydro-2-methyl-5-oxo-2-furanyl]-, (5α,17β)-

IUPAC Name

(5S)-5-methyl-5-[(5R,8R,9R,10R,13R,14R,17S)-4,4,8,10,14-pentamethyl-3-oxo-1,2,5,6,7,9,11,12,13,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]oxolan-2-one

Applications

Density

1.1±0.1 g/cm3

Solubility

COX-2 inhibitor; anti-inflammatory; antioxidant; cabralealactone; salvadorin; solasodin

Flash Point

219.5±22.7 °C

Boiling Point

516.8±23.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C27H42O3/c1-23(2)19-10-15-26(5)20(24(19,3)13-11-21(23)28)8-7-17-18(9-14-25(17,26)4)27(6)16-12-22(29)30-27/h17-20H,7-16H2,1-6H3/t17-,18+,19+,20-,24+,25-,26-,27+/m1/s1

InChl Key

NOLGXQBEFHYZHI-QPBHWVAKSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:19865-87-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

29872266

Abstract

BACKGROUND:
The present study investigates the hepato- and DNA-protective effects of standardized extracts of Cleome brachycarpa (cabralealactone), Solanum incanum (solasodin), and Salvadora oleioides (salvadorin) in rats.

MATERIALS AND METHODS:
Hepatotoxicity was induced with intraperitoneal injection of carbon tetrachloride (CCl4) (1 mL/kg b.wt.) once a week for 12 weeks. The hepato- and DNA protective effects of the extracts in different combinations were compared with that of a standard drug Clavazin (200 mg/kg b.wt.). Tissue alanine aminotransferase, alpha-fetoprotein, tumor necrosis factor alpha (TNF-α), isoprostanes-2α, malondialdehyde, and 8-hydroxydeoxyguanosine, the significant hallmarks of oxidative stress, were studied.

RESULTS:
Histopathological findings of the liver sections from the rat group which received CCl4+cabralealactone, solasodin, and salvadorin demonstrated improved centrilobular hepatocyte regeneration with moderate areas of congestion and infiltration comparable with Clavazin. For in silico study, the identified compounds were subjected to molecular docking with cyclooxygenase-2 and TNF-α followed by a molecular dynamics study, which indicated their potential as anti-inflammatory agents.

CONCLUSION:
Cabralealactone, solasodin, and salvadorin confer some hepatoprotective and DNA-damage protective effects against CCl4-induced toxicity. They successfully restored the normal architecture of hepatocytes and have the potential to be used as inhibitor to main culprits, that is, cyclooxygenase-2 and TNF-α. They can combat oxidative stress and liver injuries both as mono and combinational therapies. However, combination therapy has more ameliorating effects.

KEYWORDS

COX-2 inhibitor; anti-inflammatory; antioxidant; cabralealactone; salvadorin; solasodin

Title

In silico and in vivo characterization of cabralealactone, solasodin and salvadorin in a rat model: potential anti-inflammatory agents.

Author

Malik A1, Arooj M2, Butt TT3, Zahid S4, Zahid F1, Jafar TH1, Waquar S1, Gan SH5, Ahmad S1, Mirza MU6.

Publish date

2018 May 24