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Camphor

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-C3005

  • Specification : 95%

  • CAS number : 76-22-2

  • Formula : C10H16O

  • Molecular Weight : 152.23

  • PUBCHEM ID : 2537

  • Volume : 50mg

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Catalogue Number

BF-C3005

Analysis Method

HPLC,NMR,MS

Specification

95%

Storage

2-8°C

Molecular Weight

152.23

Appearance

powder

Botanical Source

Cinnamomum camphora

Structure Type

Terpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1(C2CCC1(C(=O)C2)C)C

Synonyms

(+)-bornan-2-one/Bicyclo(2.2.1)heptan-2-one, 1,7,7-trimethyl-/camphanone/3-Fluor-2,2-dimethyl-bicycloheptan/(1S,4S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one/1,7,7-Trimethylbicyclo[2.2.1]-2-heptanone/2-Kamfanon/D-CAMPHOR/(±)-bornan-2-one/2-Oxo-bornan/2-Bornanone,2-Camphanone,D-Camphor/Radian B/lphanon/DL-2-Bornanone/D-(+)-Camphor/Alphanon/L(-)-Camphor/1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one/DL-Camphor/Camphen-hydrofluorid/(1RS,4RS)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one/Caladryl/(-)-Camphor/2-Keto-1,7,7-trimethylnolcamphane/Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-/(−)-Camphor,(1S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one/2-CAMPHOR/(±)-Camphor/2-Camphonone/Dehydrocamphor/Camphor/(+)-CaMphor/(1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one/2-Bornanone,2-Camphanone/D(+)-Camphor/2-Bornanone 2-Camphanone/Kampfer/(+)-Camphor,(1R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one/camphre/(1S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one

IUPAC Name

1,7,7-trimethylbicyclo[2.2.1]heptan-2-one

Density

1.0±0.1 g/cm3

Solubility

Methanol

Flash Point

64.4±0.0 °C

Boiling Point

207.4±0.0 °C at 760 mmHg

Melting Point

175-177 °C(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2914290000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:76-22-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

28798338

Abstract

Understanding the mechanisms of ligand binding to enzymes is of paramount importance for the design of new drugs. Here, we report on the use of a novel biased molecular dynamics (MD) methodology to study the mechanism of camphor binding to cytochrome P450cam. Microsecond-long MD simulations allowed us to observe reaction coordinates characterizing ligand diffusion from the active site of cytochrome P450cam to solvent via three egress routes. These atomistic simulations were used to estimate thermodynamic quantities along the reaction coordinates and indicate diverse binding configurations. The results suggest that the diffusion of camphor along the pathway near the substrate recognition site (SRS) is thermodynamically preferred. In addition, we show that the diffusion near the SRS is triggered by a transition from a heterogeneous collection of closed ligand-bound conformers to the basin comprising the open conformations of cytochrome P450cam. The conformational change accompanying this switch is characterized by the retraction of the F and G helices and the disorder of the B’ helix. These results are corroborated by experimental studies and provide detailed insight into ligand binding and conformational behavior of the cytochrome family. The presented methodology is general and can be applied to other ligand-protein systems.

Title

Thermodynamics of camphor migration in cytochrome P450cam by atomistic simulations.

Author

Rydzewski J1, Nowak W2.

Publish date

2017 Aug 10


Description :

Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities[1]. Camphor is a TRPV3 agonist[2].