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Capsaicin

$78

  • Brand : BIOFRON

  • Catalogue Number : BF-C3013

  • Specification : 98%

  • CAS number : 404-86-4

  • Formula : C18H27NO3

  • Molecular Weight : 305.41

  • PUBCHEM ID : 1548943

  • Volume : 25mg

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Catalogue Number

BF-C3013

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

305.41

Appearance

White needle crystal

Botanical Source

Capsicum annuum

Structure Type

Others

Category

Standards;Natural Pytochemical;API

SMILES

CC(C)C=CCCCCC(=O)NCC1=CC(=C(C=C1)O)OC

Synonyms

(E)-Capsaicin/8-Methyl-N-vanillyl-trans-6-nonenamide/(E)-8-Methyl-N-vanillyl-6-nonenamide/(6E)-N-(4-Hydroxy-3-methoxybenzyl)-8-methyl-6-nonenamide/(E)-N-((4-Hydroxy-3-methoxyphenyl)methyl)-8-methyl-6-nonenamide/CAPSAICINE/Zostrix/trans-Capsaicin/Qutenza/(E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide/8-Methyl-N-vanillyl-6-nonenamide/6-Nonenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-, (E)-/capsaicin/(E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide/6-Nonenimidic acid, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-, (1Z,6E)-/Transacin/Capsaicin (Natural)/trans-8-methyl-n-vanillyl-6-nonenamide/(6E)-N-(4-Hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide/N-vanillyl-8-methyl-non-6-enamide/(1Z,6E)-N-(4-Hydroxy-3-methoxybenzyl)-8-methyl-6-nonenimidic acid/Styptysat/N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide/Axsain/Capsidol/6-Nonenamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-, (6E)-/8-Methyl-N-vanillyl-trans-6-nonenamide,Capsaicin/8-Methyl-N-vanillyl-6-nonenamide, (E)-/8-methyl N-vanillyl-6-nonenamide/Capsaicin, (6E)-

IUPAC Name

(E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide

Density

1.0±0.1 g/cm3

Solubility

Methanol; Acetontrile; DMSO

Flash Point

237.9±31.5 °C

Boiling Point

469.7±55.0 °C at 760 mmHg

Melting Point

62-65 °C(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2924290000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:404-86-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

27472308

Abstract

Capsaicinoids are plant secondary metabolites, capsaicin being the principal responsible for the pungency of chili peppers. It is biosynthesized through two pathways involved in phenylpropanoid and fatty acid metabolism. Plant capsaicin concentration is mainly affected by genetic, environmental and crop management factors. However, its synthesis can be enhanced by the use of elicitors. Capsaicin is employed as food additive and in pharmaceutical applications. Additionally, it has been found that capsaicin can act as a cancer preventive agent and shows wide applications against various types of cancer. This review is an approach in contextualizing the use of controlled stress on the plant to increase the content of capsaicin, highlighting its synthesis and its potential use as anticancer agent.

KEYWORDS

apoptosis; cancer; capsaicin; cell death; elicitors; stress.

Title

Capsaicin: From Plants to a Cancer-Suppressing Agent

Author

Angela M Chapa-Oliver 1 , Laura Mejia-Teniente 2

Publish date

2016 Jul 27

PMID

29198921

Abstract

Capsaicin, a well known vanilloid, has shown evidence of an ample variety of biological effects which make it the target of extensive research ever since its identification. In spite of the fact that capsaicin causes health hazards in quite a few ways, yet, the verity cannot be ignored that capsaicin has several therapeutic implications. In patients with hypersensitive bladders, vesical instillation of 1 mM capsaicin markedly improved urinary frequency and urge incontinence. Again, administration of capsaicin favors an augmentation in lipid mobilization and a decrease in adipose tissue mass. Topical capsaicin cream as well decreases postsurgical neuropathic pain and is preferred by patients over a placebo among other therapies. Several in vitro studies have revealed that capsaicin results in growth arrest in some transformed cell lines. Furthermore, capsaicin has been proven to be an undeniably exciting molecule and remains a valuable drug for alleviating pain and itch. It has been recognized that capsaicinoids are the most potential agonists of capsaicin receptor (TRPV1). However, vanilloids could exert the beneficial effects not only through the receptor-dependent pathway but also through the receptor-independent one. The involvement of serotonin, neuropeptide Substance P and somatostatin in the pharmacological actions of capsaicin has been expansively investigated. Better understanding of the established TRPV1 receptor mechanism as well as exploring other possible receptor mechanism may publicize other new clinical efficacies of capsaicin. Further, clinical studies are required in several of these conditions to establish the efficacy of capsaicin.

KEYWORDS

apoptosis; cancer; capsaicin; cell death; elicitors; stress.

Title

Research Progress of Capsaicin Responses to Various Pharmacological Challenges

Author

Pompy Patowary 1 , Manash Pratim Pathak 1 , Kamaruz Zaman 2 , P S Raju 3 , Pronobesh Chattopadhyay 4

Publish date

2017 Dec

PMID

29191767

Abstract

Capsaicin is the principal constituent of oleoresin capsicum, or pepper spray, as it is commonly known. Pepper sprays are frequently used in riot control situations by defence organizations all over the world to deal with uncontrolled civil or criminal disturbances. Although capsaicin is noted for its irritant and inflammatory properties, the ocular profile of capsaicin has not been specifically studied and interpreted. The present review analyses the mammalian opthalmological profile of capsaicin and its pharmacological and toxicological manifestations including capsaicin induced corneal changes, neurogenic inflammation, neuroprotective influences on retinal ganglion cells (RGCs), depletion of neuropeptide content in sensory nerve terminals etc. Substantial views on the capsaicin receptor Transient Receptor Potential Vanilloid V1 (TRPV1), its presence, significance and capsaicin induced mediations have been presented. Studies conducted previously on the reversal of capsaicin evoked ocular responses have been briefly demonstrated. In this regard, TRPV1 antagonists (especially the competitive antagonist Capsazepine) have been indicated as potential candidates in mitigating or alleviating capsaicin elicited ocular responses. The review overall is a comprehensive perspective of the ocular inflammatory and pharmacological responses generated on exposure to capsaicin and concludes suggesting a possible regulatory framework for relief from the same presumably by the employment of specialized and target specific TRPV1 antagonists.

KEYWORDS

Capsaicin; Inflammation; Irritation; Ocular; Pharmacology; TRPV1.

Title

Capsaicin, the Primary Constituent of Pepper Sprays and Its Pharmacological Effects on Mammalian Ocular Tissues

Author

Harshita Krishnatreyya 1 , Hemanga Hazarika 2 , Achintya Saha 3 , Pronobesh Chattopadhyay 4

Publish date

2018 Jan 15


Description :

Capsaicin is a TRPV1 agonist with an EC50 of 0.29 μM in HEK293 cells.