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Capsanthin

$480

  • Brand : BIOFRON

  • Catalogue Number : BN-O1311

  • Specification : 98%(HPLC)

  • CAS number : 465-42-9

  • Formula : C40H56O3

  • Molecular Weight : 584.9

  • PUBCHEM ID : 5281228

  • Volume : 20mg

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Catalogue Number

BN-O1311

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

584.9

Appearance

Botanical Source

Structure Type

Category

SMILES

CC1=C(C(CC(C1)O)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC(=O)C2(CC(CC2(C)C)O)C)C)C

Synonyms

(3R,3'S,5'R)-3,3'-Dihydroxy-b,k-caroten-6'-one/capsanthin/β,κ-Caroten-6'-one, 3,3'-dihydroxy-, (3R,3'S,5'R)-/Paprika Extract,Vegetable oil/Paprika Extract/(2E,4E,6E,8E,10E,12E,14E,16E,18E)-19-[(4R)-4-Hydroxy-2,6,6-trimethyl-1-cyclohexen-1-yl]-1-[(1R,4S)-4-hydroxy-1,2,2-trimethylcyclopentyl]-4,8,13,17-tetramethyl-2,4,6,8,10,12,14,16,18-nonadecanonaen-1-one/(3R,3'S,5'R)-3,3'-Dihydroxy-β,κ-caroten-6'-one

IUPAC Name

(2E,4E,6E,8E,10E,12E,14E,16E,18E)-19-[(4R)-4-hydroxy-2,6,6-trimethylcyclohexen-1-yl]-1-[(1R,4S)-4-hydroxy-1,2,2-trimethylcyclopentyl]-4,8,13,17-tetramethylnonadeca-2,4,6,8,10,12,14,16,18-nonaen-1-one

Density

1.0±0.1 g/cm3

Solubility

Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.

Flash Point

407.2±29.4 °C

Boiling Point

726.6±60.0 °C at 760 mmHg

Melting Point

177-178ºC

InChl

InChl Key

VYIRVAXUEZSDNC-RDJLEWNRSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:465-42-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

28449555

Abstract

Adipogenesis in murine preadipocyte 3T3L-1 has been used as a model system to study anti-obese bioactive molecules. During adipogenesis in 3T3-L1 preadipocytes, we found that capsanthin inhibited adipogenesis (IC₅₀; 2.5 μM) and also showed lipolytic activity in differentiated adipocytes from the preadipocytes (ED₅₀; 872 nM). We identified that the pharmacological activity of capsanthin on adipogenesis in 3T3-L1 was mainly due to its adrenoceptor-β₂-agonistic activity. In high-fat diet animal model study, capsanthin significantly enhanced spontaneous locomotive activities together with progressive weight-loss. The capsanthin-induced activation of kinetic behavior in mice was associated with the excessive production of ATP initiated by both the enhanced lipolytic activity together with accelerated oxidation of fatty acids due to the adrenoceptor β₂-agonistic activity of capsanthin. Capsanthin also dose-dependently increased adiponectin and p-AMPK activity in high fat diet animals, suggesting that capsanthin has both anti-obesity and insulin sensitizing activities.

KEYWORDS

Adiponectin; Anti-adipogenic; Capsanthin; Lypolytic activity; Spontaneous locomotive activity

Title

Capsanthin Inhibits both Adipogenesis in 3T3-L1 Preadipocytes and Weight Gain in High-Fat Diet-Induced Obese Mice.

Author

Jo SJ1, Kim JW1, Choi HO1, Kim JH1, Kim HJ1, Woo SH2, Han BH1.

Publish date

2017 May 1

PMID

31904006

Abstract

A method for the simultaneous determination of 17 kinds of phthalate esters in capsanthin was developed by the QuEChERS (quick, easy, cheap, effective, ruggedand safe) pretreatment method coupled with gas chromatography-mass spectrometry(GC-MS). Capsanthin samples were extracted with acetonitrile, and then sodium chloride and anhydrous magnesium sulfate were added for salting out. After the extracting liquids were cleansed by florisil, the supernatants were analyzed by GC-MS. The limits of detection (LOD) and limits of quantitation (LOQ) ranged from 0.2 to 0.5 μg/g and 0.6 to 1.5 μg/g, respectively. DMP, DEP, DAP, DIBP, DBP, BMPP, DPP, DHXP and DCHP were in the range of 0.2 – 10 μg/g; DMEP, DEEP, BBP, DBEP, DEHP, DPhP, DNOP and DNP were in the range of 0.5 – 20 μg/g. And all had good linearity and the linear correlation coefficients (R2) were more than 0.995. The average recoveries of 17 kinds of PAEs of the three levels were between 82.8 and 118.1%, and the relative standard deviations (RSDs) were between 0.12 and 7.3%. It is a simple, rapid, accurate and reliable method for the rapid detection of PAEs in large quantities of natural plant extract samples.

KEYWORDS

Capsanthin; QuEChERS; gas chromatography-mass spectrometry; phthalate esters; rapid detection

Title

Rapid Determination of 17 Phthalate Esters in Capsanthin by QuEChERS Coupled with Gas Chromatography-Mass Spectrometry.

Author

Niu Y1, Gao W1, Li H2, Zhang J3, Lian Y4.

Publish date

2020 Apr 10

PMID

27229653

Abstract

The reaction of paprika carotenoids, capsanthin and capsorubin, with reactive oxygen species (ROS), such as superoxide anion radical (·O2(-)), hydroxyl radical (·OH), and singlet oxygen ((1)O2), was analyzed by LC/PDA ESI-MS and ESR spectrometry. Capsanthin formed both the 5,6-epoxide and 5,8-epoxide by reaction with ·O2(-) and ·OH. Furthermore, capsanthin also formed 5,6- and 5,8-endoperoxide on reaction with (1)O2. The same results were obtained in the case of capsanthin diacetate. On the other hand, capsorubin showed higher stability against these ROS. Capsorubin formed 7,8-epoxide on reaction with ·O2(-) and ·OH and 7,8-endoperoxide on reaction with (1)O2.

KEYWORDS

capsanthin; capsanthin endoperoxide; capsanthin epoxide; capsorubin; reactive oxygen species

Title

Reaction of Paprika Carotenoids, Capsanthin and Capsorubin, with Reactive Oxygen Species.

Author

Nishino A1, Yasui H2, Maoka T3.

Publish date

2016 Jun 15


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