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Casticin

$143

  • Brand : BIOFRON

  • Catalogue Number : BF-C2018

  • Specification : 98%

  • CAS number : 479-91-4

  • Formula : C19H18O8

  • Molecular Weight : 374.34

  • PUBCHEM ID : 5315263

  • Volume : 20mg

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Catalogue Number

BF-C2018

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

374.34

Appearance

Yellow crystalline powder

Botanical Source

Vitex negundo,Artemisia annua,Artemisia rupestris,Vitex negundo var. cannabifolia,Vitex trifolia

Structure Type

Flavonoids

Category

Standards;Natural Pytochemical;API

SMILES

COC1=C(C=C(C=C1)C2=C(C(=O)C3=C(C(=C(C=C3O2)OC)OC)O)OC)O

Synonyms

Casticin/quercetagetin-3,6,7,4'-tetramethylether/3,4',6,7-Tetramethoxy-3',5-dihydroxyflavone/5,3'-DIHYDROXY-3,6,7,4'-TETRAMETHOXYFLAVONE/Vitexicarpin/4H-1-Benzopyran-4-one, 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxy-/Agnus castus fruit/Casticine/VITEXICARPIM/4H-1-Benzopyran-4-one,5-hydroxy-2/3',5-dihydroxy-3,4',6,7-tetramethoxyflavone/5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxy-4H-chromen-4-one

IUPAC Name

5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxychromen-4-one

Density

1.4±0.1 g/cm3

Solubility

Methanol; Ethyl Acetate

Flash Point

223.5±25.0 °C

Boiling Point

617.7±55.0 °C at 760 mmHg

Melting Point

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2932990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:479-91-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

29876982

Abstract

Casticin, a compound purified from the Chinese herb Viticis Fructus, has been proven effective in preventing tumor progression in previous studies. Ulcerative colitis (UC) is a common inflammatory bowel disease that affects millions of people worldwide, but no effective and safe drugs are available. In this study, we aimed to study how did casticin affect UC by evaluating its effects on dextran sulfate sodium (DSS)-induced colitis in mice. Our data suggested that casticin attenuated body weight loss, colon length shortening, and pathological damage in the colon of DSS-treated mice. Casticin decreased reactive oxygen species level and chemocytokines (IL-1β, IL-6, TNF-α) productions in colon tissue. The decreased reactive oxygen species level and suppressed proinflammatory cytokines productions were also confirmed in casticin-treated LPS-stimulated RAW264.7 cells and hydrogen peroxide-treated CACO-2 cells in vitro. Mechanistically, casticin treatment prevented the profound activation of AKT signaling caused by DSS administration. And casticin inhibited the productions of proinflammatory chemocytokines through downregulating AKT/NF-κB pathway in macrophages. Meanwhile, data revealed that casticin increased expressions of endogenous antioxidants peroxiredoxin 3 and MnSOD were through activation in FOXO3α signaling by downregulating AKT signaling in colon epithelium cells. Our findings demonstrated that casticin alleviated DSS-induced UC by increasing the antioxidant enzyme peroxiredoxin 3 and MnSOD expressions, and decreasing the production of proinflammatory chemocytokines through inhibition of AKT signaling.
Copyright © 2018 John Wiley & Sons, Ltd.

Title

Casticin prevents DSS induced ulcerative colitis in mice through inhibitions of NF-κB pathway and ROS signaling.

Author

Ma J1, Yin G2, Lu Z1, Xie P1, Zhou H1, Liu J1, Yu L1.

Publish date

2018 Sep

PMID

29665364

Abstract

Casticin (3′, 5-dihydroxy-3, 4′, 6, 7-tetramethoxyflavone), one of the main components from Vitex rotundifolia L., was reported to possess several pharmacological properties, including anti-inflammatory, hepatoprotective, anticancer, anti-asthma activities. However, the effects of casticin on airway smooth muscle cells (ASMCs) proliferation and migration have not been explored. This study aimed to evaluate the effects of casticin on the proliferation and migration of ASMCs, and study the possible molecular mechanism. Our results demonstrated that casticin significantly suppressed the proliferation and migration of ASMCs exposed to platelet-derived growth factor (PDGF), as well as reversed the PDGF-induced inhibition of the expression of contractile phenotype markers in ASMCs. In addition, casticin also inhibited PDGF-induced the expression of type I collagen and fibronectin in ASMCs induced by PDGF. Furthermore, casticin significantly prevented the activation of ERK1/2 and NF-κB pathways in PDGF-stimulated ASMCs. Taken together, these data demonstrated that casticin inhibits PDGF-induced human ASMC proliferation and migration through suppressing the activation of ERK1/2 and NF-κB signaling pathways.
Copyright © 2018 Elsevier B.V. All rights reserved.

KEYWORDS

ASMCs; Asthma; Casticin; Migration; PDGF

Title

Casticin inhibits PDGF-induced proliferation and migration of airway smooth muscle cells.

Author

Dai Y1, Cheng R2, Gao J2, Li Y2, Lou C2, Li Y2.

Publish date

2018 Jul 5

PMID

30391743

Abstract

Casticin, an active compound isolated from Vitex rotundifolia L., was reported to possess anti-inflammatory activity. However, the effect of casticin on inflammatory response in human osteoarthritis (OA) chondrocytes remains unclear. In the current study, we examined the anti-inflammatory effects of casticin on chondrocytes exposed to interleukin-1β (IL-1β). Our results demonstrated that casticin treatment significantly improved cell viability in chondrocytes exposed to IL-1β. Casticin significantly inhibited IL-1β-induced NO and PGE2 production, and iNOS and COX-2 expression in human OA chondrocytes. It also suppressed the levels of TNF-α and IL-6, as well as decreased production of MMP-3, MMP-13, ADAMTS-4 and ADAMTS-5 in IL-1β-stimulated chondrocytes. Furthermore, casticin prevented IL-1β-induced NF-κB activation in chondrocytes. Taken together, these findings showed that casticin attenuates inflammatory responses in chondrocytes stimulated with IL-1β, possibly through the NF-κB signaling pathway. Thus, casticin may serve as a potential anti-inflammatory agent in the treatment of OA.

KEYWORDS

Casticin; IL-1β; Inflammation; NF-κB pathway; Osteoarthritis (OA)

Title

Casticin protects against IL-1β-induced inflammation in human osteoarthritis chondrocytes.

Author

Mu Y1, Hao W1, Li S2.

Publish date

2019 Jan 5


Description :

Casticin is a methyoxylated flavonol isolated from Viticis Fructus, with antimitotic and anti-inflammatory effect. Casticin inhibits the activation of STAT3.