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Catalogue Number
AV-C10456
Analysis Method
HPLC,NMR,MS
Specification
98%
Storage
2-8°C
Molecular Weight
258.3
Appearance
Powder
Botanical Source
Structure Type
Sesquiterpenoids
Category
Standards;Natural Pytochemical;API
SMILES
CC1(CC=C(C(=O)O1)C2C3=CC=CC=C3C(=O)O2)C
Synonyms
3-(5,6-Dihydro-6,6-dimethyl-2-oxo-2H-pyran-3-yl)-1(3H)-isobenzofuranone/1(3H)-Isobenzofuranone, 3-(5,6-dihydro-6,6-dimethyl-2-oxo-2H-pyran-3-yl)-/Catalpalactone/3-(6,6-Dimethyl-2-oxo-5,6-dihydro-2H-pyran-3-yl)-2-benzofuran-1(3H)-one
IUPAC Name
3-(2,2-dimethyl-6-oxo-3H-pyran-5-yl)-3H-2-benzofuran-1-one
Applications
Density
1.3±0.1 g/cm3
Solubility
Flash Point
245.2±27.1 °C
Boiling Point
467.1±45.0 °C at 760 mmHg
Melting Point
InChl
InChI=1S/C15H14O4/c1-15(2)8-7-11(14(17)19-15)12-9-5-3-4-6-10(9)13(16)18-12/h3-7,12H,8H2,1-2H3
InChl Key
GFYSRANGENPXDF-UHFFFAOYSA-N
WGK Germany
RID/ADR
HS Code Reference
2933990000
Personal Projective Equipment
Correct Usage
For Reference Standard and R&D, Not for Human Use Directly.
Meta Tag
provides coniferyl ferulate(CAS#:1585-68-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
No Technical Documents Available For This Product.
21783893
The effects of catalpalactone on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells were investigated. Catalpalactone at 5-30μM decreased intracellular dopamine content with the IC(50) value of 22.1μM. Catalpalactone at 5-20μM, but not 30μM, did not alter cell viability. Catalpalactone at 20μM inhibited tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities. Catalpalactone also decreased cyclic AMP levels and inhibited TH phosphorylation. In addition, catalpalactone at 20μM reduced the increases in dopamine levels induced by L-DOPA (20-50μM). Catalpalactone (5-30μM) associated with L-DOPA (50-100μM) enhanced L-DOPA-induced cytotoxicity at 48h, which was prevented by N-acetyl-l-cysteine. These results suggest that catalpalactone inhibited dopamine biosynthesis by reducing TH and AADC activities and enhanced L-DOPA-induced cytotoxiciy in PC12 cells.
Effects of catalpalactone on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells.
Huang HS1, Han XH, Hwang BY, Park JI, Yoo SK, Lee HJ, Lim SC, Lee MK.
2008 Jul
6076788
Structure of catalpalactone, a new phthalide from Catalpa wood.
Inoue H, Okuda T, Hirata Y, Nagakura N, Yoshizaki M.
1967 Jun
5844740
The structure of catalpalactone.
Inouye H, Okuda T, Hirata Y, Nagakura N, Yoshizaki M.
1965 May
