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Catalpalactone

$905

  • Brand : BIOFRON

  • Catalogue Number : AV-C10456

  • Specification : 98%

  • CAS number : 1585-68-8

  • Formula : C15H14O4

  • Molecular Weight : 258.3

  • PUBCHEM ID : 3014018

  • Volume : 5mg

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Catalogue Number

AV-C10456

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

258.3

Appearance

Powder

Botanical Source

Structure Type

Sesquiterpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1(CC=C(C(=O)O1)C2C3=CC=CC=C3C(=O)O2)C

Synonyms

3-(5,6-Dihydro-6,6-dimethyl-2-oxo-2H-pyran-3-yl)-1(3H)-isobenzofuranone/1(3H)-Isobenzofuranone, 3-(5,6-dihydro-6,6-dimethyl-2-oxo-2H-pyran-3-yl)-/Catalpalactone/3-(6,6-Dimethyl-2-oxo-5,6-dihydro-2H-pyran-3-yl)-2-benzofuran-1(3H)-one

IUPAC Name

3-(2,2-dimethyl-6-oxo-3H-pyran-5-yl)-3H-2-benzofuran-1-one

Applications

Density

1.3±0.1 g/cm3

Solubility

Flash Point

245.2±27.1 °C

Boiling Point

467.1±45.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C15H14O4/c1-15(2)8-7-11(14(17)19-15)12-9-5-3-4-6-10(9)13(16)18-12/h3-7,12H,8H2,1-2H3

InChl Key

GFYSRANGENPXDF-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:1585-68-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

21783893

Abstract

The effects of catalpalactone on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells were investigated. Catalpalactone at 5-30μM decreased intracellular dopamine content with the IC(50) value of 22.1μM. Catalpalactone at 5-20μM, but not 30μM, did not alter cell viability. Catalpalactone at 20μM inhibited tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities. Catalpalactone also decreased cyclic AMP levels and inhibited TH phosphorylation. In addition, catalpalactone at 20μM reduced the increases in dopamine levels induced by L-DOPA (20-50μM). Catalpalactone (5-30μM) associated with L-DOPA (50-100μM) enhanced L-DOPA-induced cytotoxicity at 48h, which was prevented by N-acetyl-l-cysteine. These results suggest that catalpalactone inhibited dopamine biosynthesis by reducing TH and AADC activities and enhanced L-DOPA-induced cytotoxiciy in PC12 cells.

Title

Effects of catalpalactone on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells.

Author

Huang HS1, Han XH, Hwang BY, Park JI, Yoo SK, Lee HJ, Lim SC, Lee MK.

Publish date

2008 Jul

PMID

6076788

Title

Structure of catalpalactone, a new phthalide from Catalpa wood.

Author

Inoue H, Okuda T, Hirata Y, Nagakura N, Yoshizaki M.

Publish date

1967 Jun

PMID

5844740

Title

The structure of catalpalactone.

Author

Inouye H, Okuda T, Hirata Y, Nagakura N, Yoshizaki M.

Publish date

1965 May