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Chrysin

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-C3006

  • Specification : 98%

  • CAS number : 480-40-0

  • Formula : C15H10O4

  • Molecular Weight : 254.24

  • PUBCHEM ID : 5281607

  • Volume : 25mg

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Catalogue Number

BF-C3006

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

254.24

Appearance

Pale yellow crystal

Botanical Source

Vaccinium bracteatum,Erigeron annuus,Hyssopus cuspidatus,Malus doumeri,Populus davidiana

Structure Type

Flavonoids

Category

Standards;Natural Pytochemical;API

SMILES

C1=CC=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O

Synonyms

5,7-Dihydroxyflavone/Chrysin/5,7-dihydroxy-2-phenylchromen-4-one/5,7-Dihydroxy-2-phenyl-4H-chromen-4-one/Chrysidenon 1438/Chrysinic acid/4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-phenyl-

IUPAC Name

5,7-dihydroxy-2-phenylchromen-4-one

Density

1.4±0.1 g/cm3

Solubility

Methanol

Flash Point

192.5±22.2 °C

Boiling Point

491.9±45.0 °C at 760 mmHg

Melting Point

284-286 °C(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2932990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:480-40-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

31472146

Abstract

Chrysin is a promising phytochemical that is categorized under the class of flavonoids based on its chemical structure. Naturally, it is widely present in propolis, honey, passion fruit, and even in mushrooms and other plant sources, whereas its synthetic counterparts are also being employed for pharmacological purposes. It has widely been employed in treatment of various degenerative disorders and provides cytotoxic and anti-inflammatory functions. Its antioxidant and disease preventing abilities are attributed to its structural diversity arising in ring-A and absence of oxygenation in B and C ring. In this review, the scientific studies are being reported emphasizing benefits and its allied health claims on chrysin in numerous metabolic malfunctions.
Copyright © 2019 Elsevier Inc. All rights reserved.

KEYWORDS

Anti-inflammatory; Antioxidant; Chrysin; Cytotoxic; Flavonoids; Health claims

Title

Chrysin: Pharmacological and therapeutic properties.

Author

Naz S1, Imran M2, Rauf A3, Orhan IE4, Shariati MA5, Iahtisham-Ul-Haq6, IqraYasmin7, Shahbaz M8, Qaisrani TB8, Shah ZA9, Plygun S10, Heydari M11.

Publish date

2019 Oct 15

PMID

29161583

Abstract

In recent years, public and scientific interest in plant flavonoids has tremendously increased because of their postulated health benefits. This review was mainly focuses on the flavone chrysin (5,7-dihydroxyflavone), which occurs naturally in many plants, honey, and propolis. A number of in vitro and in vivo studies have revealed the therapeutic effects of chrysin against various diseases. In general, chrysin exhibits many biological activities and pharmacological effects, including antioxidant, anti-inflammatory, anticancer, and antiviral activities. Moreover, many studies have reported on the bioavailability of chrysin. Because of its compromised bioavailability and enhanced protein stability, chrysin solid lipid nanoparticle (SLN) synthesis avoids proteolytic degradation and sustained release of drug delivery. To clarify the mechanism of action of chrysin, researchers have investigated the structural binding relationship of chrysin through the docking computation method.
Copyright © 2017 Elsevier Ltd. All rights reserved.

KEYWORDS

Bioavailability; Chrysin; Molecular docking; Passiflora caerulea; Passifloraceae; Pharmacological activities

Title

Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action.

Author

Mani R1, Natesan V2.

Publish date

2018 Jan

PMID

29050978

Abstract

We previously reported the inhibitory effect of chrysin, a natural flavonoid plentifully contained in propolis, vegetables and fruits, on the mast cell-mediated allergic reaction. In this study, we evaluated the effect of chrysin on atopic dermatitis (AD) and defined underlying mechanisms of action. We used an AD model in BALB/c mice by the repeated local exposure of 2,4-dinitrochlorobenzene (DNCB) and house dust mite (Dermatophagoides farinae extract, DFE) to the ears. Repeated alternative treatment of DNCB/DFE caused AD-like skin lesions. Oral administration of chrysin diminished AD symptoms such as ear thickness and histopathological analysis, in addition to serum IgE and IgG2a levels. Chrysin decreased infiltration of mast cells, and reduced serum histamine level. Chrysin also suppressed AD by inhibiting the inflammatory responses of Th1, Th2, and Th17 cells in mouse lymph node and ear. Interestingly, chrysin significantly inhibited the production of cytokines, Th2 chemokines, CCL17 and CCL22 by the down-regulation of p38 MAPK, NF-κB, and STAT1 in tumor necrosis factor (TNF)-α/interferon (IFN)-γ-stimulated human keratinocytes (HaCaT). Chrysin also inhibited TNF-α/IFN-γ-stimulated IL-33 expression in HaCaT cells and mouse primary keratinocytes. Taken together, the results indicate that chrysin suppressed AD symptoms, suggesting that chrysin might be a candidate for the treatment of AD and skin allergic diseases.
Copyright © 2017 Elsevier Ltd. All rights reserved.

KEYWORDS

Atopic dermatitis; Chrysin; IL-33; Keratinocytes

Title

Chrysin attenuates atopic dermatitis by suppressing inflammation of keratinocytes.

Author

Choi JK1, Jang YH2, Lee S3, Lee SR4, Choi YA1, Jin M1, Choi JH5, Park JH5, Park PH6, Choi H6, Kwon TK7, Khang D8, Kim SH9.

Publish date

2017 Dec


Description :

Chrysin is one of the most well known estrogen blockers.