Cynomorium songaricum,Punica granatum,Vitis vinifera,Paeonia lactiflora,Paeonia suffruticosa
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provides coniferyl ferulate(CAS#:154-23-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
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Synthesis and radical-scavenging activity of a dimethyl catechin analogue. PUMID/DOI：24792463 Bioorg Med Chem Lett. 2014 Jun 1;24(11):2582-4. Catechin analogue 1 with methyl substituents ortho to the catechol hydroxyl groups was synthesized to improve the antioxidant ability of (+)-Catechin. The synthetic scheme involved a solid acid catalyzed Friedel-Crafts coupling of a cinnamyl alcohol derivative to 3,5-dibenzyloxyphenol followed by hydroxylation and then cyclization through an intermediate orthoester. The antioxidative radical scavenging activity of 1 against galvinoxyl radical, an oxyl radical, was found to be 28-fold more potent than (+)-Catechin. Effect of emulsification on the skin permeation and UV protection of catechin. PUMID/DOI：23639253 Pharm Dev Technol. 2014 Jun;19(4):395-400. An anti-aging effect may be obtained by skin application of tea Catechins (Camellia sinensis) since they have high ultraviolet (UV)-protection activity. In this study, the skin permeation of Catechin (C), epiCatechin (EC), epigalloCatechin (EGC), epiCatechin gallate (ECg) and epigalloCatechin gallate (EGCg) was determined and compared, and the effect of emulsification on the skin permeation of C was measured. The UV-protective effect of C was also determined. The in vitro skin permeability of each Catechin derivative was determined using side-by-side diffusion of cells. The UV-protective effect of C was determined by applying different concentrations of C to the solution or emulsion on a three-dimensional cultured human skin model or normal human epidermal keratinocytes with UV-irradiation. ECg and EGCg with gallate groups showed lower skin permeability than C, EC and EGC without gallate groups, suggesting that the skin permeability of Catechin derivatives may be dependent on the existence of a gallate group. Interestingly, the skin permeation of C was increased by an o/w emulsification. In addition, the C emulsion showed a significantly higher UV-protective effect by C than that with its aqueous solution. These results suggest that the o/w emulsion of Catechin derivatives is probably useful as a cosmetic formulation with anti-aging efficacy. Antiviral effect of catechins in green tea on influenza virus. PUMID/DOI：16137775 Antiviral Res. 2005 Nov;68(2):66-74. Polyphenolic compound Catechins ((-)-epigalloCatechin gallate (EGCG), (-)-epiCatechin gallate (ECG) and (-)-epigalloCatechin (EGC)) from green tea were evaluated for their ability to inhibit influenza virus replication in cell culture and for potentially direct virucidal effect. Among the test compounds, the EGCG and ECG were found to be potent inhibitors of influenza virus replication in MDCK cell culture and this effect was observed in all influenza virus subtypes tested, including A/H1N1, A/H3N2 and B virus. The 50% effective inhibition concentration (EC50) of EGCG, ECG, and EGC for influenza A virus were 22-28, 22-40 and 309-318 microM, respectively. EGCG and ECG exhibited hemagglutination inhibition activity, EGCG being more effective. However, the sensitivity in hemagglutination inhibition was widely different among three different subtypes of influenza viruses tested. Quantitative RT-PCR analysis revealed that, at high concentration, EGCG and ECG also suppressed viral RNA synthesis in MDCK cells whereas EGC failed to show similar effect. Similarly, EGCG and ECG inhibited the neuraminidase activity more effectively than the EGC. The results show that the 3-galloyl group of Catechin skeleton plays an important role on the observed antiviral activity, whereas the 5'-OH at the trihydroxy benzyl moiety at 2-position plays a minor role. The results, along with the HA type-specific effect, suggest that the antiviral effect of Catechins on influenza virus is mediated not only by specific interaction with HA, but altering the physical properties of viral membrane. Catechin intake might explain the inverse relation between tea consumption and ischemic heart disease: the Zutphen Elderly Study. PUMID/DOI：11470725 Am J Clin Nutr. 2001 Aug;74(2):227-32. The mean (+/-SD) Catechin intake at baseline was 72 +/- 47.8 mg, mainly from black tea, apples, and chocolate. A total of 90 deaths from ischemic heart disease were documented. Catechin intake was inversely associated with ischemic heart disease mortality; the multivariate-adjusted risk ratio in the highest tertile of intake was 0.49 (95% CI: 0.27, 0.88; P for trend: 0.017). After multivariate adjustment, Catechin intake was not associated with the incidence of myocardial infarction (risk ratio in the highest tertile of intake: 0.70; 95% CI: 0.39, 1.26; P for trend: 0.232). After adjustment for tea consumption and flavonol intake, a 7.5-mg increase in Catechin intake from sources other than tea was associated with a tendency for a 20% reduction in ischemic heart disease mortality risk (P = 0.114). There was no association between Catechin intake and stroke incidence or mortality.||CONCLUSION:||Catechins, whether from tea or other sources, may reduce the risk of ischemic heart disease mortality but not of stroke.