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Chicoric acid is polyphenol of natural plant and has a variety of bioactivity. Caused by various kinds of stimulating factors, acute liver injury has high fatality rate. The effect of chicoric acid in acute liver injury induced by Lipopolysaccharide (LPS) and d‐galactosamine (d‐GalN) was investigated in this study. The results showed that CA decreased the aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum and reduced the mortality induced by LPS/d‐GalN. CA can restrain mitogen‐activated protein kinases (MAPKs) and nuclear factor‐kappa B (NF‐κB) to alleviate inflammation. Meanwhile, the results indicated CA can active nuclear factor‐erythroid 2‐related factor 2 (Nrf2) pathway with increasing the level of AMP‐activated protein kinase (AMPK). And with the treatment of CA, protein levels of autophagy genes were obvious improved. The results of experiments indicate that CA has protective effect in liver injury, and the activation of AMPK and autophagy may make sense.
acute liver injury, AMPK, autophagy, CA, d‐GalN, LPS, MAPK, NF‐κB, Nrf2
Chicoric acid ameliorate inflammation and oxidative stress in Lipopolysaccharide and d‐galactosamine induced acute liver injury
Zheng Li, 1 Haihua Feng, 1 Lu Han, 1 Lu Ding, 1 Bingyu Shen, 1 Ye Tian, 1 Lilei Zhao, 1 Meiyu Jin, 1 Qi Wang, 1 Haiyan Qin, 1 Jiaqi Cheng, 1 and Guowen Liucorresponding author 1
Aging is a process characterized by accumulating degenerative damages, resulting in the death of an organism ultimately. The main goal of aging research is to develop therapies that delay age-related diseases in human. Since signaling pathways in aging of Caenorhabditis elegans (C. elegans), fruit flies and mice are evolutionarily conserved, compounds extending lifespan of them by intervening pathways of aging may be useful in treating age-related diseases in human. Natural products have special resource advantage and with few side effect. Recently, many compounds or extracts from natural products slowing aging and extending lifespan have been reported. Here we summarized these compounds or extracts and their mechanisms in increasing longevity of C. elegans or other species, and the prospect in developing anti-aging medicine from natural products.
Aging, Natural products, Anti-aging, Drug screening
Current Perspective in the Discovery of Anti-aging Agents from Natural Products
Ai-Jun Ding,1,2 Shan-Qing Zheng,1,2 Xiao-Bing Huang,1,2 Ti-Kun Xing,1,2 Gui-Sheng Wu,1,3 Hua-Ying Sun,1 Shu-Hua Qi,4 and Huai-Rong Luocorresponding author1,3,5