Constit. of Cimicifuga racemosa
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
773.3±60.0 °C at 760 mmHg
HS Code Reference
Personal Projective Equipment
For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:290821-39-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
This study aimed to identify the dietary patterns of Koreans, comparing them according to their living arrangements, and to determine factors associated with the patterns. We analyzed nutritional data of 6719 Korean adults aged 19-64 years from the 2013-2015 Korea National Health and Nutrition Examination Survey using the exploratory factor and hierarchical and k-means cluster analyses. We used multinominal logistic regression to compare factors associated with each dietary pattern. We identified three dietary patterns based on meal preference and dessert type: “traditional meal with healthy dessert”, “meal only”, and “unhealthy dessert” (Kaiser-Meyer-Olkin = 0.90, Bartlett’s test of sphericity p < 0.001). The “unhealthy dessert” dietary pattern was more frequent in people living alone (51.7%) than in those living with others (41.8%). Weight control, dining out, eating breakfast, and sleep were significantly associated with the “meal only”; eating breakfast was associated with the “unhealthy dessert” dietary pattern among those living alone. Lifestyle factors were associated with unhealthy dietary patterns in Korean adults living alone, warranting the need for a healthy diet and promotion of modifiable health behaviors for this subgroup. Thus, clinicians must provide comprehensive assessments and multidimensional interventions while considering lifestyle factors and unhealthy dietary patterns to improve the health status of them.
diet, living arrangements, life style, nutrition surveys
Comparative Study of Dietary Patterns by Living Arrangements: The Korea National Health and Nutrition Examination Survey (KNHANES) 2013-2015
Namhee Kim,1 Go-Un Kim,1 and Heejung Kim1,2,*
Institutionalized people with dementia have an increased risk of fall accidents, but little is known about whether this increased risk holds for home dwellers.
This register- and population-based study comprised 115,584 cases and 394,679 controls. Cases were individuals with any fall between 2009 and 2014, and matched with up to six controls on age, sex, and geographic location. Individuals were excluded if they (1) had any fall in 2008, or (2) lived in a nursing home on the date of the fall. Dementia, other chronic diseases, and sedative medicines were assessed from Danish national registers.
After adjusting for potential confounders, older people with dementia living at home had a 1.89-fold higher risk of fall (odds ratio = 1.89, 95% confidence interval [1.84-1.94], P < .001). Discussion Dementia almost doubles the risk of fall for older Danish people living at home. This highlights the need for effective fall preventions that target people with dementia.
Dementia, Falls, Comorbidity, Sedative medicine, Home dwellers
The risk of fall accidents for home dwellers with dementia—A register- and population-based case-control study
Jindong Ding Petersen,a,b,∗ Volkert Dirk Siersma,c Rene dePont Christensen,a Maria Munch Storsveen,a Connie Thurøe Nielsen,b and Frans Boch Waldorffa
Enfuvirtide (ENF), the first approved fusion inhibitor (FI) for HIV, is a 36-aa peptide that acts by binding to the heptad repeat 1 (HR1) region of gp41 and preventing the interaction of the HR1 and HR2 domains, which is required for virus-cell fusion. Treatment-acquired resistance to ENF highlights the need to create FI therapeutics with activity against ENF-resistant viruses and improved durability. Using rational design, we have made a series of oligomeric HR2 peptides with increased helical structure and with exceptionally high HR1/HR2 bundle stability. The engineered peptides are found to be as much as 3,600-fold more active than ENF against viruses that are resistant to the HR2 peptides ENF, T-1249, or T-651. Passaging experiments using one of these peptides could not generate virus with decreased sensitivity, even after >70 days in culture, suggesting superior durability as compared with ENF. In addition, the pharmacokinetic properties of the engineered peptides were improved up to 100-fold. The potent antiviral activity against resistant viruses, the difficulty in generating resistant virus, and the extended half-life in vivo make this class of fusion inhibitor peptide attractive for further development.
coiled coil, gp41 HIV-1, viral entry, drug design
Design of helical, oligomeric HIV-1 fusion inhibitor peptides with potent activity against enfuvirtide-resistant virus
John J. Dwyer,* Karen L. Wilson, Donna K. Davison, Stephanie A. Freel, Jennifer E. Seedorff, Stephen A. Wring, Nicolai A. Tvermoes, Thomas J. Matthews, Michael L. Greenberg, and Mary K. Delmedico
2007 Jul 31