cinnamic alcohol/stylone/trans-3-phenyl-2-propen-1-ol/Peruvin/Ciamyl alcohol/STYRYL CARBINOL/Cinnamylalkohol/(E)-cinnamyl alcohol/(E)-3-phenylprop-2-en-1-ol/3-PHENYLALLYLOL/(2E)-3-phenylprop-2-en-1-ol/Sterone/(2E)-3-Phenyl-2-propen-1-ol/Cinnamyl alcohol/3-phenylprop-2-en-1-ol/3-Phenyl/allylic benzylic alcohol/cinnamyl alcohol, (E)-isomer/Chnnamyl alcohol/cynnamyl alcohol/Styrylicalcohol/3-phenyl-2-propen-1-ol/2-Propen-1-ol, 3-phenyl-, (2E)-
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provides coniferyl ferulate(CAS#:104-54-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
The extract of chestnut (Castanea crenata var. dulcis) flower (CCDF) has antioxidant and antimelanogenic properties, but its anti-obesity properties have not been previously examined. In this study, we tested the effect of CCDF absolute on adipocyte differentiation by using 3T3-L1 cells and determining the bioactive component of CCDF absolute in 3T3-L1 cell differentiation. CCDF absolute (0.1-100[Formula: see text][Formula: see text]g/mL) did not change 3T3-L1 cell viability. At 50[Formula: see text][Formula: see text]g/mL and 100[Formula: see text][Formula: see text]g/mL, the absolute significantly reduced the accumulation of lipid droplets in 3T3-L1 cells that were induced by culture in medium containing 3-isobutyl-1-methylxanthine/dexamethasone/insulin (MDI). GC/MS analysis showed that CCDF absolute contains 10 compounds. Among these compounds, cinnamyl alcohol (3-phenyl-2-propene-1-ol) dose-dependently inhibited the increased accumulation of lipid droplets in MDI-contained medium-cultured 3T3-L1 cells at a concentration range of 0.1[Formula: see text][Formula: see text]g/mL to 10[Formula: see text][Formula: see text]g/mL that did not cause cytotoxicity in 3T3-L1 cells. The inhibitory effect was significant at 5[Formula: see text][Formula: see text]g/mL ([Formula: see text] of response in MDI alone-treated state, [Formula: see text]) and 10[Formula: see text][Formula: see text]g/mL ([Formula: see text] of response in MDI alone-treated state, [Formula: see text]). Moreover, the enhanced expression of obesity-related proteins (PPAR[Formula: see text], C/EBP[Formula: see text], SREBP-1c, and FAS) in MDI medium-cultivated 3T3-L1 cells was significantly attenuated by the addition of cinnamyl alcohol at 5[Formula: see text][Formula: see text]g/mL and 10[Formula: see text][Formula: see text]g/mL. These findings demonstrate that cinnamyl alcohol suppresses 3T3-L1 cell differentiation by inhibiting anti-adipogenesis-related proteins, and it may be a main bioactive component of CCDF absolute, exerting antidifferentiation action in 3T3-L1 cells. Therefore, cinnamyl alcohol, as well as CCDF absolute, may be potential candidates for the prevention or treatment of obesity.
3T3-L1 Preadipocytes; Absolutes; Adipogenesis; Castanea crenata; Cinamyl Alcohol; Obesity.
Cinnamyl Alcohol, the Bioactive Component of Chestnut Flower Absolute, Inhibits Adipocyte Differentiation in 3T3-L1 Cells by Downregulating Adipogenic Transcription Factors
Dae Il Hwang 1 , Kyung-Jong Won 2 , Do-Yoon Kim 1 , Bokyung Kim 2 , Hwan Myung Lee 1
Background: Cinnamyl alcohol is considered to be a prohapten and prehapten with cinnamal as the main metabolite. However, many individuals who are allergic to cinnamyl alcohol do not react to cinnamal. Sensitizing epoxides of cinnamyl alcohol and cinnamal have been identified as metabolites and autoxidation products of cinnamyl alcohol.
Objective: To investigate the clinical relevance of contact allergy to epoxycinnamyl alcohol and epoxycinnamal.
Methods: Irritative effects of the epoxides were investigated in 12 dermatitis patients. Epoxycinnamyl alcohol and epoxycinnamal were patch tested in 393 and 390 consecutive patients, respectively. In parallel, cinnamyl alcohol and cinnamal were patch tested in 607 and 616 patients, respectively.
Results: Both epoxides were irritants, but no more positive reactions were detected than when testing was performed with cinnamyl alcohol and cinnamal. Late allergic reactions to epoxycinnamyl alcohol were observed. In general, patients with late reactions showed doubtful or positive reactions to cinnamal and fragrance mix I at regular patch testing.
Conclusion: The investigated epoxides are not important haptens in contact allergy to cinnamon fragrance. The high frequency of fragrance allergy among patients included in the irritancy study showed the difficulty of suspecting fragrance allergy on the basis of history; patch testing broadly with fragrance compounds is therefore important.
autoxidation; cinnamal; cinnamyl alcohol; cutaneous metabolism; epoxycinnamal; epoxycinnamyl alcohol; fragrance contact allergy; late allergic reactions; patch test.
Can the Epoxides of Cinnamyl Alcohol and Cinnamal Show New Cases of Contact Allergy?
Lina Hagvall 1 , Ida B Niklasson 2 , Kristina Luthman 3 , Ann-Therese Karlberg 2
The present study aims at synthesizing and in vitro antibacterial activity evaluation of chitosan oligosaccharide (COS) modified by Cinnamyl alcohol (Cin) onto the OH position of COS. Three different degrees of substitution (DS) COS-O-Cin1-3 were synthesized by changing different molar ratios of COS to Cin. UV-visible spectroscopy (UV-vis), Fourier transform infrared (FT-IR), 1H nuclear magnetic resonance (1H NMR), thermogravimetric analysis (TGA), X-ray diffraction (XRD) and elemental analysis were conducted to characterize the successful synthesis of COS-O-Cin1-3. The results showed that they exhibited higher thermal stability, weaker crystallinity and better antibacterial properties than that of COS. These results aided in obtaining the important supports for exploring new functional antibacterial agents, which expand the scope of COS’s application in the food industry.
Antibacterial activity; Chitosan oligosaccharide; Cinnamyl alcohol; Stability.
Cinnamyl Alcohol Modified Chitosan Oligosaccharide for Enhancing Antimicrobial Activity
Lin Yue 1 , Dan Sun 2 , Imran Mahmood Khan 2 , Xiaoli Liu 2 , Qixing Jiang 2 , Wenshui Xia 2
2020 Mar 30
Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, with anti-obesity activity.