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Citral

$52

  • Brand : BIOFRON

  • Catalogue Number : BD-P0643

  • Specification : 98.0%(GC)

  • CAS number : 5392-40-5

  • Formula : C10H16O

  • Molecular Weight : C10H16O

  • Volume : 0.2ml

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Catalogue Number

BD-P0643

Analysis Method

Specification

98.0%(GC)

Storage

2-8°C

Molecular Weight

C10H16O

Appearance

Botanical Source

Structure Type

Monoterpenoids

Category

SMILES

CC(=CCCC(=CC=O)C)C

Synonyms

Lemsyn GB/3,7-Dimethyl-1,2,6-octadienal/3,7-Dimethyl-2,6-octadienal,Geranial and neral mixture/LEMAROME/2,6-octadienal, 3,7-dimethyl-/(2E)-3,7-Dimethyl-2,6-octadienal/NERAL/gerznial/lemsyngb/3,7-Dimethylocta-2,6-dienal/3,7-dimethyl-2,6-octadien-1-al/3,7-Dimethyl-2,6-octadienal/LEMSYN/GERANIAL/3,7-dimethyl-trans-2,6-octadienal/2,6-Octadienal, 3,7-dimethyl-, (2E)-/Citral

IUPAC Name

Applications

Density

0.9±0.1 g/cm3

Solubility

Methanol; Chloroform

Flash Point

101.7±0.0 °C

Boiling Point

229.0±9.0 °C at 760 mmHg

Melting Point

< -10ºC

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:5392-40-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

31948629

Abstract

The growing demand for minimally processed foods with clean labels has stimulated research into mild processing methods and natural antimicrobials to replace intensive heating and conventional preservatives, respectively. However, we have previously demonstrated that repetitive exposure of some bacteria to mild heat or subinhibitory concentrations of essential oil constituents (EOCs) may induce the emergence of mutants with increased resistance to these treatments. Since the combination of mild heat with some EOCs has a synergistic effect on microbial inactivation, we evaluated the potential of such combinations against our resistant E. coli mutants. While citral, carvacrol and t-cinnamaldehyde synergistically increased heat inactivation (53.0 °C, 10 min) of the wild-type MG1655 suspended in buffer, only the combination with carvacrol (200 μl/l) was able to mitigate the increased resistance of all the mutants. Moreover, the combination of heat and carvacrol acted synergistically inactivating heat-resistant variants of E. coli O157:H7 (ATCC 43888). This combined treatment could synergistically achieve more than 5 log10 reductions of the most resistant mutants in coconut water, although the temperature had to be raised to 57.0 °C. Therefore, the combination of mild heat with carvacrol appears to hold promise for mild processing, and it is expected to counteract the development of heat resistance.

Copyright © 2019 Elsevier Ltd. All rights reserved.

KEYWORDS

Carvacrol; Citral; Coconut water; E. coli O157:H7; Hurdle technology; Mild heat; Resistance development; t-Cinnamaldehyde

Title

Combination of mild heat and plant essential oil constituents to inactivate resistant variants of Escherichia coli in buffer and in coconut water.

Author

Gayan E1, Geens E2, Berdejo D3, Garcia-Gonzalo D3, Pagan R3, Aertsen A2, Michiels CW4.

Publish date

2020 May;

PMID

31670280

Abstract

Citral; gamma-aminobutyric acid A receptor; glycine receptor; patch clamp; substantia gelatinosa neuron

KEYWORDS

Citral; gamma-aminobutyric acid A receptor; glycine receptor; patch clamp; substantia gelatinosa neuron

Title

Action of citral on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in juvenile mice.

Author

Nguyen TTP1, Jang SH2, Park SJ2, Cho DH3, Han SK2.

Publish date

2019 Sep-Oct;

PMID

31492037

Abstract

Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death among females globally. The tumorigenic activities of cancer cells such as aldehyde dehydrogenase (ALDH) activity and differentiation have contributed to relapse and eventual mortality in breast cancer. Thus, current drug discovery research is focused on targeting breast cancer cells with ALDH activity and their capacity to form secondary tumors. Citral (3,7-dimethyl-2,6-octadienal), from lemon grass (Cymbopogon citrates), has been previously reported to have a cytotoxic effect on breast cancer cells. Hence, this study was conducted to evaluate the in vivo effect of citral in targeting ALDH activity of breast cancer cells. BALB/c mice were challenged with 4T1 breast cancer cells followed by daily oral feeding of 50 mg/kg citral or distilled water for two weeks. The population of ALDH+ tumor cells and their capacity to form secondary tumors in both untreated and citral treated 4T1 challenged mice were assessed by Aldefluor assay and tumor growth upon cell reimplantation in normal mice, respectively. Citral treatment reduced the size and number of cells with ALDH+ activity of the tumors in 4T1-challenged BALB/c mice. Moreover, citral-treated mice were also observed with smaller tumor size and delayed tumorigenicity after reimplantation of the primary tumor cells into normal mice. These findings support the antitumor effect of citral in targeting ALDH+ cells and tumor recurrence in breast cancer cells.

KEYWORDS

ALDH; breast cancer; citral; tumorigenicity

Title

In Vivo Anti-Tumor Effects of Citral on 4T1 Breast Cancer Cells via Induction of Apoptosis and Downregulation of Aldehyde Dehydrogenase Activity.

Author

Nigjeh SE1,2,3, Yeap SK4, Nordin N5, Rahman H6,7, Rosli R8,9.

Publish date

2019 Sep 5