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Citreorosein

$960

  • Brand : BIOFRON

  • Catalogue Number : BN-O1616

  • Specification : 98%(HPLC)

  • CAS number : 481-73-2

  • Formula : C15H10O6

  • Molecular Weight : 286.2

  • PUBCHEM ID : 361512

  • Volume : 5mg

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Catalogue Number

BN-O1616

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

286.2

Appearance

Yellow powder

Botanical Source

This product is isolated and purified from the root and rhizome of Rheum palmatum L.

Structure Type

Anthraquinones

Category

Standards;Natural Pytochemical;API

SMILES

C1=C(C=C(C2=C1C(=O)C3=C(C2=O)C(=CC(=C3)O)O)O)CO

Synonyms

1,3,8-Trihydroxy-6-(hydroxymethyl)-9,10-anthraquinone/Citreorosein/9,10-Anthracenedione, 1,3,8-trihydroxy-6-(hydroxymethyl)-/1,3,8-Trihydroxy-6-hydroxymethylanthraquinone/1,3,8-Trihydroxy-6-(hydroxymethyl)anthra-9,10-quinone

IUPAC Name

1,3,8-trihydroxy-6-(hydroxymethyl)anthracene-9,10-dione

Density

1.7±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

374.4±28.0 °C

Boiling Point

672.3±55.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C15H10O6/c16-5-6-1-8-12(10(18)2-6)15(21)13-9(14(8)20)3-7(17)4-11(13)19/h1-4,16-19H,5H2

InChl Key

YQHZABGPIPECSQ-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2914690000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:481-73-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

31549123

Abstract

A chemoenzymatic reduction of citreorosein by the NADPH-dependent polyhydroxyanthracene reductase from Cochliobolus lunatus or MdpC from Aspergillus nidulans in the presence of Na2S2O4 gave access to putative biosynthetic intermediates, (R)-3,8,9,10-tetrahydroxy-6-(hydroxymethyl)-3,4-dihydroanthracene-1(2H)-one and its oxidized form, (R)-3,4-dihydrocitreorosein. Herein, we discuss the implications of these results towards the (bio)synthesis of aloe-emodin and (+)-rugulosin C in fungi.

Title

Chemoenzymatic reduction of citreorosein and its implications on aloe-emodin and rugulosin C (bio)synthesis.

Author

Mondal A1, Saha N1, Rajput A1, Singh SK1, Roy B2, Husain SM1

Publish date

2019 Oct 14

PMID

22395859

Abstract

The aim of this study was to evaluate whether citreorosein (CIT), a naturally occurring anthraquinone isolated from Polygoni cuspidati (P. cuspidati) radix, modulates degranulation and 5-lipoxygenase (5-LO)-dependent leukotriene C(4) (LTC(4)) generation in mast cells. Cit suppresses both degranulation and the generation of LTC(4) in a dose-dependent manner in stem cell factor (SCF)-mediated mouse bone marrow-derived mast cells (BMMCs). With regard to its molecular mechanism of action, we investigated the effects of CIT on intracellular signaling and mast cell activation employing BMMCs. Binding of SCF to c-Kit on mast cell membranes induced increases in intrinsic tyrosine kinase Syk activity and activation of multiple downstream events including phosphorylation of phospholipase Cγ (PLCγ), mobilization of intracellular Ca(2+), phosphatidylinositol 3-kinase (PI3K), Akt, MAP kinases (MAPKs), translocation of phospho-phospholipase A(2) (PLA(2)) and 5-LO. The results from the biochemical analysis demonstrate that CIT attenuates degranulation and LTC(4) generation through the suppression of multiple step signaling and would be beneficial for the prevention of allergic inflammation.

Title

Citreorosein inhibits degranulation and leukotriene C₄ generation through suppression of Syk pathway in mast cells.

Author

Lu Y1, Li Y, Jahng Y, Son JK, Chang HW

Publish date

2012 Jun


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