We Offer Worldwide Shipping
Login Wishlist

Citropten

$68

  • Brand : BIOFRON

  • Catalogue Number : AV-P11461

  • Specification : 98%

  • CAS number : 487-06-9

  • Formula : C11H10O4

  • Molecular Weight : 206.19

  • PUBCHEM ID : 2775

  • Volume : 25mg

Available on backorder

Quantity
Checkout Bulk Order?

Catalogue Number

AV-P11461

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

206.19

Appearance

White crystalline powder

Botanical Source

Finger Citron

Structure Type

Coumarins

Category

Standards;Natural Pytochemical;API

SMILES

COC1=CC2=C(C=CC(=O)O2)C(=C1)OC

Synonyms

5,7-Dimethoxy-2H-1-benzopyran-2-one/5,7-dimethoxy-coumarin/Limettin/Citropten/5,7-Dimethoxy-2H-chromen-2-one/2H-1-Benzopyran-2-one, 5,7-dimethoxy-/5,7-dimethoxychromen-2-one/5,7-Dimethoxycoumarin/5,7-Dimethoxy-chromen-2-one

IUPAC Name

5,7-dimethoxychromen-2-one

Density

1.2±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

176.3±27.9 °C

Boiling Point

388.1±42.0 °C at 760 mmHg

Melting Point

146-149 °C(lit.)

InChl

InChI=1S/C11H10O4/c1-13-7-5-9(14-2)8-3-4-11(12)15-10(8)6-7/h3-6H,1-2H3

InChl Key

NXJCRELRQHZBQA-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:487-06-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

1878243

Abstract

Citropten (5,7-dimethoxycoumarin) and bergapten (5-methoxypsoralen) are present in bergamot oil which is used as a cosmetic tanning product. The aim of this study was to quantify, using HPLC, the amount of citropten and bergapten in the skin after the application of suntan products (emulsion and oil formulations). A suction blister technique, performed on the volar aspect of the forearm, permitted the collection of these two molecules. The blister fluid concentrations were 37 and 51 ng/ml (emulsion) and 26 and 23 ng/ml (oil), respectively, for citropten and bergapten. Our results show that the suction blister technique could be used for comparing transepidermal penetration of several compounds in vivo in man.

Title

Citropten and bergapten suction blister fluid concentrations after solar product application in man.

Author

Treffel P1, Makki S, Faivre B, Humbert P, Blanc D, Agache P.

Publish date

1991

PMID

2056004

Abstract

Citropten (5,7-dimethoxycoumarin) and bergapten (5-methoxypsoralen) are present in bergamot oil which is used as a tanning cosmetic product. The aim of this study was to quantify, using high-performance liquid chromatography, the amount of citropten and bergapten in the skin after suntan products application (an emulsion and an oil formulation). A suction blister technique performed of the anterior aspect of the forearm permitted the collection of these two accumulated molecules. Fluorometric and ultraviolet detections were used for citropten and bergapten determinations, respectively.

Title

High-performance liquid chromatographic determination of citropten and bergapten in suction blister fluid after solar product application in humans.

Author

Makki S1, Treffel P, Humbert P, Agache P.

Publish date

1991 Feb

PMID

26893562

Abstract

For the first time, we coupled reduced detonation nanodiamonds (NDs) with a plant secondary metabolite, citropten (5,7-dimethoxycoumarin), and demonstrated how this complex was able to reduce B16F10 tumor cell growth more effectively than treatment with the pure molecule. These results encouraged us to find out the specific mechanism underlying this phenomenon. Internalization kinetics and quantification of citropten in cells after treatment with its pure or ND-conjugated form were measured, and it was revealed that the coupling between NDs and citropten was essential for the biological properties of the complex. We showed that the adduct was not able to induce apoptosis, senescence, or differentiation, but it determined cell cycle arrest, morphological changes, and alteration of mRNA levels of the cytoskeletal-related genes. The identification of metaphasic nuclei and irregular disposition of β-actin in the cell cytoplasm supported the hypothesis that citropten conjugated with NDs showed antimitotic properties in B16F10 cells. This work can be considered a pioneering piece of research that could promote and support the biomedical use of plant drug-functionalized NDs in cancer therapy.

KEYWORDS

citropten; cytoskeletal structure; internalization kinetics; melanoma; plant secondary metabolite

Title

Nanodiamonds coupled with 5,7-dimethoxycoumarin, a plant bioactive metabolite, interfere with the mitotic process in B16F10 cells altering the actin organization.

Author

Gismondi A1, Nanni V1, Reina G2, Orlanducci S2, Terranova ML2, Canini A1.

Publish date

2016 Feb


Description :

Citropten (5,7-Dimethoxycoumarin) is a coumarin isolated from bergamot oil. Citropten (5,7-Dimethoxycoumarin) has an antiproliferative activity against A2058 human melanoma cell line[1][2].