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Cleroindicin C

$1,024

  • Brand : BIOFRON

  • Catalogue Number : BN-O1583

  • Specification : 98%(HPLC)

  • CAS number : 183626-28-0

  • Formula : C8H12O3

  • Molecular Weight : 156.18

  • PUBCHEM ID : 10975728

  • Volume : 5mg

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Catalogue Number

BN-O1583

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

156.18

Appearance

Botanical Source

Structure Type

Category

SMILES

C1CC2(CCOC2CC1=O)O

Synonyms

(3aS,7aR)-3a-Hydroxyhexahydro-1-benzofuran-6(2H)-one/6(2H)-Benzofuranone, hexahydro-3a-hydroxy-, (3aS,7aR)-

IUPAC Name

(3aR,7aS)-3a-hydroxy-2,3,4,5,7,7a-hexahydro-1-benzofuran-6-one

Density

1.3±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

126.8±20.0 °C

Boiling Point

303.0±37.0 °C at 760 mmHg

Melting Point

InChl

InChl Key

ZCBQZDMJIVJQLX-JGVFFNPUSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:183626-28-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

26929360

Abstract

The eukaryotic proteasome mediates degradation of polyubiquitinated proteins. Here we report the single-particle cryoelectron microscopy (cryo-EM) structures of the endogenous 26S proteasome from Saccharomyces cerevisiae at 4.6- to 6.3-a resolution. The fine features of the cryo-EM maps allow modeling of 18 subunits in the regulatory particle and 28 in the core particle. The proteasome exhibits two distinct conformational states, designated M1 and M2, which correspond to those reported previously for the proteasome purified in the presence of ATP-γS and ATP, respectively. These conformations also correspond to those of the proteasome in the presence and absence of exogenous substrate. Structure-guided biochemical analysis reveals enhanced deubiquitylating enzyme activity of Rpn11 upon assembly of the lid. Our structures serve as a molecular basis for mechanistic understanding of proteasome function.

KEYWORDS

protein degradation, proteasome, cryo-EM, structure

Title

Structure of an endogenous yeast 26S proteasome reveals two major conformational states

Author

Bai Luan,a,1 Xiuliang Huang,a,1 Jianping Wu,a Ziqing Mei,b Yiwei Wang,a Xiaobin Xue,a Chuangye Yan,a Jiawei Wang,a Daniel J. Finley,c Yigong Shi,a,2 and Feng Wanga,2

Publish date

2016 Mar 8;

PMID

31709106

Abstract

In the crystal structures of the title com­pounds, namely μ-aqua-κ2 O:O-di-μ-di­phenyl­acetato-κ4 O:O′-bis­[(di­phenyl­acetato-κO)bis­(pyridine-κN)nickel(II)], [Ni2(C14H11O2)4(C5H5N)4(H2O)] (1) and μ-aqua-κ2 O:O-di-μ-di­phenyl­acetato-κ4 O:O′-bis­[(2,2′-bi­pyridine-κ2 N,N′)(di­phenyl­acetato-κO)nickel(II)]-aceto­nitrile-di­phenyl­acetic acid (1/2.5/1), [Ni2(C14H11O2)4(C10H8N2)2(H2O)]·2.5CH3CN·C14H12O2 (2), the com­plex units are stabilized by a variety of intra- and inter­molecular hydrogen bonds, as well as C—H⋯π and π-π contacts between the aromatic systems of the pyridine, dipyridyl and di­phenyl­acetate ligands. Despite the fact that the di­phenyl­acetate ligand is sterically bulky, this does not inter­fere with the formation of the described aqua-bridged dimeric core, even with a 2,2′-bi­pyridine ligand, which has a strong chelating effect.

KEYWORDS

crystal structure, NiII dimer, carboxyl­ate com­plex, Hirshfeld surface analysis, hydrogen bonds, π-stacking

Title

Crystal structures of two dimeric nickel di­phenyl­acetate com­plexes

Author

A. A. Nikiforov,a,b D. O. Blinou,a E. N. Dubrov,a N. S. Panina,a A. I. Ponyaev,a V. V. Gurzhiy,c,‡ A. V. Eremin,b,d,* and A. I. Fischera

Publish date

2019 Nov 1;

PMID

13328149

Title

Social Factors in the Aetiology of Nephritis in Childhood

Author

Norman S. Clark

Publish date

1956 Jun


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