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Clinodiside A

$111

  • Brand : BIOFRON

  • Catalogue Number : BD-D1215

  • Specification : 98%(HPLC)

  • CAS number : 916347-31-4

  • Formula : C48H78O19

  • Molecular Weight : 959.125

  • PUBCHEM ID : 71571492

  • Volume : 20MG

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Catalogue Number

BD-D1215

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

959.125

Appearance

White crystalline powder

Botanical Source

Cliruo podium polycephalum(Vani-ot)C.Y.Wu et Hsuan

Structure Type

Triterpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1(CCC2(C(CC3(C(=C2C1)C=CC4C3(CC(C5C4(CCC(C5)OC6C(C(C(C(O6)COC7C(C(C(C(O7)CO)O)O)O)OC8C(C(C(C(O8)CO)O)O)O)O)O)C)(C)CO)C)C)O)CO)C

Synonyms

Clinodiside A/β-D-Galactopyranoside, (3β,16β)-16,23,28-trihydroxyoleana-11,13(18)-dien-3-yl O-β-D-glucopyranosyl-(1->2)-O-β-D-glucopyranosyl-(1->3)-6-deoxy-/N1207/(3β,16β)-16,23,28-Trihydroxyoleana-11,13(18)-dien-3-yl β-D-glucopyranosyl-(1->2)-β-D-glucopyranosyl-(1->3)-6-deoxy-β-D-galactopyranoside/Buddlejasaponin centob

IUPAC Name

2-[[4,5-dihydroxy-6-[[8-hydroxy-5,8a-bis(hydroxymethyl)-5,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,6,7,8,9,10,12,14a-dodecahydropicen-3-yl]oxy]-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol

Applications

Clinodiside A is isolated from the Chinese medicinal herb Clinopodium chinensis[1].

Density

1.4±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

591.3±34.3 °C

Boiling Point

1054.2±65.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C48H78O19/c1-43(2)11-12-48(21-52)24(14-43)23-7-8-28-45(4)10-9-22(13-29(45)44(3,20-51)19-47(28,6)46(23,5)15-30(48)53)63-41-38(61)35(58)39(67-42-37(60)34(57)32(55)26(17-50)65-42)27(66-41)18-62-40-36(59)33(56)31(54)25(16-49)64-40/h7-8,22,25-42,49-61H,9-21H2,1-6H3

InChl Key

HVRAMEAUCOTBHH-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2938900000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:916347-31-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

28486105

Title

CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes

Author

Limin Xia,1,2,6 Wenjie Huang,2,6 Marina Bellani,3 Michael M. Seidman,3 Kaichun Wu,2 Daiming Fan,2 Yongzhan Nie,2 Yi Cai,1 Yang W. Zhang,1 Li-Rong Yu,4 Huili Li,1 Cynthia A. Zahnow,1 Wenbing Xie,1 Ray-Whay Chiu Yen,1 Feyruz V. Rassool,5,* and Stephen B. Baylin1,7

Publish date

2017 May 8

PMID

30775536

Abstract

Objectives
Hip fracture is a major public health problem. Earlier studies projected that the total number of hip fracture will increase dramatically by 2050, and most of the hip fracture will occur in Asia. To date, only a few studies provided the updated projection, and none of them focused on the hip fracture projection in Asia. Thus, it is essential to provide the most up to date prediction of hip fracture in Asia, and to evaluate the total direct medical cost of hip fracture in Asia.

Methods
We provide the updated projection of hip fracture in 9 Asian Federation of Osteoporosis Societies members using the most updated incidence rate and projected population size.

Results
We show that the number of hip fracture will increase from 1,124,060 in 2018 to 2,563,488 in 2050, a 2.28-fold increase. This increase is mainly due to the changes on the population demographics, especially in China and India, which have the largest population size. The direct cost of hip fracture will increase from 9.5 billion United State dollar (USD) in 2018 to 15 billion USD in 2050, resulting a 1.59-fold increase. A 2%-3% decrease in incidence rate of hip fracture annually is required to keep the total number of hip fracture constant over time.

Conclusions
The results show that hip fracture remains a key public health issue in Asia, despite the available of better diagnosis, treatment, and prevention of fracture over the recent years. Healthcare policy in Asia should be aimed to reduce the burden of hip fracture.

KEYWORDS

Hip fracture, Asia, Osteoporosis, Incidence

Title

An updated hip fracture projection in Asia: The Asian Federation of Osteoporosis Societies study

Author

Ching-Lung Cheung,a,b Seng Bin Ang,c,d Manoj Chadha,e,f Eddie Siu-Lun Chow,b,g Yoon-Sok Chung,h,i Fen Lee Hew,j,k Unnop Jaisamrarn,l,m Hou Ng,n,o Yasuhiro Takeuchi,p,q Chih-Hsing Wu,r,s Weibo Xia,t,u Julie Yu,v,w and Saeko Fujiwaraq,x,∗

Publish date

2018 Mar 22

PMID

27920993

Abstract

Digital PCR offers very high sensitivity compared to many other technologies for processing molecular detection assays. Herein, a process is outlined for determining the lower limit of detection (LoD) of two droplet-based digital PCR assays for point mutations of the epidermal growth factor receptor (EGFR) gene. Hydrolysis probe mutation-detection assays for EGFR p.L858R and p.T790M mutations were characterized in detail. Furthermore, sixteen additional cancer-related mutation assays were explored by the same approach. For the EGFR L8585R assay, the assay sensitivity is extremely good, and thus, the LoD is limited by the amount of amplifiable DNA that is analyzed. With 95% confidence limits, the LoD is one mutant in 180,000 wild-type molecules for the evaluation of 3.3 μg of genomic DNA, and detection of one mutant molecule in over 4 million wild-type molecules was achieved when 70 million copies of DNA were processed. The measured false-positive rate for the EGFR L8585R assay is one in 14 million, which indicates the theoretical LoD if an unlimited amount of DNA is evaluated. For the EFGR T790M assay, the LoD is one mutant in 13,000 for analysis of a 3.3 μg sample of genomic DNA, and the dPCR assay limit sensitivity approaches one mutant in 22,000 wild-type molecules.

Abbreviations: PCR, Polymerase Chain Reaction; EGFR, epidermal growth factor receptor; LoB, limit of blank; LoD, limit of detection; N, total number of droplet events counted; NWT, number of droplets with only wild-type DNA; NMut, number of droplets with only mutated DNA; λ, average number of targets “loaded” per droplet; p, fraction of PCR-positive droplets; R, ratio of mutant to wild-type molecules; ΛFP, average number of false-positive events; RFP, average false positive rate (ΛFP/#WT)

KEYWORDS

Digital PCR, Mutation detection, Limit of detection, Assay sensitivity, EGFR L858R, EGFR T790M

Title

Determining lower limits of detection of digital PCR assays for cancer-related gene mutations

Author

Coren A. Milbury,1,⁎ Qun Zhong,1 Jesse Lin, Miguel Williams, Jeff Olson, Darren R. Link, and Brian Hutchison

Publish date

2014 Sep