White crystalline powder
Cliruo podium polycephalum(Vani-ot)C.Y.Wu et Hsuan
Clinodiside A/β-D-Galactopyranoside, (3β,16β)-16,23,28-trihydroxyoleana-11,13(18)-dien-3-yl O-β-D-glucopyranosyl-(1->2)-O-β-D-glucopyranosyl-(1->3)-6-deoxy-/N1207/(3β,16β)-16,23,28-Trihydroxyoleana-11,13(18)-dien-3-yl β-D-glucopyranosyl-(1->2)-β-D-glucopyranosyl-(1->3)-6-deoxy-β-D-galactopyranoside/Buddlejasaponin centob
Clinodiside A is isolated from the Chinese medicinal herb Clinopodium chinensis.
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
1054.2±65.0 °C at 760 mmHg
HS Code Reference
Personal Projective Equipment
For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:916347-31-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes
Limin Xia,1,2,6 Wenjie Huang,2,6 Marina Bellani,3 Michael M. Seidman,3 Kaichun Wu,2 Daiming Fan,2 Yongzhan Nie,2 Yi Cai,1 Yang W. Zhang,1 Li-Rong Yu,4 Huili Li,1 Cynthia A. Zahnow,1 Wenbing Xie,1 Ray-Whay Chiu Yen,1 Feyruz V. Rassool,5,* and Stephen B. Baylin1,7
2017 May 8
Hip fracture is a major public health problem. Earlier studies projected that the total number of hip fracture will increase dramatically by 2050, and most of the hip fracture will occur in Asia. To date, only a few studies provided the updated projection, and none of them focused on the hip fracture projection in Asia. Thus, it is essential to provide the most up to date prediction of hip fracture in Asia, and to evaluate the total direct medical cost of hip fracture in Asia.
We provide the updated projection of hip fracture in 9 Asian Federation of Osteoporosis Societies members using the most updated incidence rate and projected population size.
We show that the number of hip fracture will increase from 1,124,060 in 2018 to 2,563,488 in 2050, a 2.28-fold increase. This increase is mainly due to the changes on the population demographics, especially in China and India, which have the largest population size. The direct cost of hip fracture will increase from 9.5 billion United State dollar (USD) in 2018 to 15 billion USD in 2050, resulting a 1.59-fold increase. A 2%-3% decrease in incidence rate of hip fracture annually is required to keep the total number of hip fracture constant over time.
The results show that hip fracture remains a key public health issue in Asia, despite the available of better diagnosis, treatment, and prevention of fracture over the recent years. Healthcare policy in Asia should be aimed to reduce the burden of hip fracture.
Hip fracture, Asia, Osteoporosis, Incidence
An updated hip fracture projection in Asia: The Asian Federation of Osteoporosis Societies study
Ching-Lung Cheung,a,b Seng Bin Ang,c,d Manoj Chadha,e,f Eddie Siu-Lun Chow,b,g Yoon-Sok Chung,h,i Fen Lee Hew,j,k Unnop Jaisamrarn,l,m Hou Ng,n,o Yasuhiro Takeuchi,p,q Chih-Hsing Wu,r,s Weibo Xia,t,u Julie Yu,v,w and Saeko Fujiwaraq,x,∗
2018 Mar 22
Digital PCR offers very high sensitivity compared to many other technologies for processing molecular detection assays. Herein, a process is outlined for determining the lower limit of detection (LoD) of two droplet-based digital PCR assays for point mutations of the epidermal growth factor receptor (EGFR) gene. Hydrolysis probe mutation-detection assays for EGFR p.L858R and p.T790M mutations were characterized in detail. Furthermore, sixteen additional cancer-related mutation assays were explored by the same approach. For the EGFR L8585R assay, the assay sensitivity is extremely good, and thus, the LoD is limited by the amount of amplifiable DNA that is analyzed. With 95% confidence limits, the LoD is one mutant in 180,000 wild-type molecules for the evaluation of 3.3 μg of genomic DNA, and detection of one mutant molecule in over 4 million wild-type molecules was achieved when 70 million copies of DNA were processed. The measured false-positive rate for the EGFR L8585R assay is one in 14 million, which indicates the theoretical LoD if an unlimited amount of DNA is evaluated. For the EFGR T790M assay, the LoD is one mutant in 13,000 for analysis of a 3.3 μg sample of genomic DNA, and the dPCR assay limit sensitivity approaches one mutant in 22,000 wild-type molecules.
Abbreviations: PCR, Polymerase Chain Reaction; EGFR, epidermal growth factor receptor; LoB, limit of blank; LoD, limit of detection; N, total number of droplet events counted; NWT, number of droplets with only wild-type DNA; NMut, number of droplets with only mutated DNA; λ, average number of targets “loaded” per droplet; p, fraction of PCR-positive droplets; R, ratio of mutant to wild-type molecules; ΛFP, average number of false-positive events; RFP, average false positive rate (ΛFP/#WT)
Digital PCR, Mutation detection, Limit of detection, Assay sensitivity, EGFR L858R, EGFR T790M
Determining lower limits of detection of digital PCR assays for cancer-related gene mutations
Coren A. Milbury,1,⁎ Qun Zhong,1 Jesse Lin, Miguel Williams, Jeff Olson, Darren R. Link, and Brian Hutchison