Shipping to United States We Offer Worldwide Shipping
Login Wishlist

Coniferyl ferulate

$427

  • Brand : BIOFRON

  • Catalogue Number : BD-D1206

  • Specification : 98%(HPLC)

  • CAS number : 63644-62-2

  • Formula : C20H20O6

  • Molecular Weight : 356.37

  • PUBCHEM ID : 6441913

  • Volume : 50MG

Available on backorder

Quantity
Checkout Bulk Order?

Catalogue Number

BD-D1206

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

356.37

Appearance

Yellow paste

Botanical Source

Ligusticum chuanxiong Hort

Structure Type

Lignanoids

Category

Standards;Natural Pytochemical;API

SMILES

COC1=C(C=CC(=C1)C=CCOC(=O)C=CC2=CC(=C(C=C2)O)OC)O

Synonyms

(2E)-3-(4-Hydroxy-3-methoxyphenyl)-2-propen-1-yl (2E)-3-(4-hydroxy-3-methoxyphenyl)acrylate/2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, (2E)-3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-yl ester, (2E)-/[(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enyl] (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate/2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, 3-(4-hydroxy-3-methoxyphenyl)-2-propenyl ester

IUPAC Name

[(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enyl] (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate

Applications

Coniferyl ferulate, a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis, reverses multidrug resistance and downregulates P-glycoprotein. Coniferyl ferulate shows strong inhibition of human placental GST with an IC50 of 0.3 μM

Density

1.3±0.1 g/cm3

Solubility

Methanol; Dichloromethane; Ethyl Acetate

Flash Point

202.8±23.6 °C

Boiling Point

570.5±50.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C20H20O6/c1-24-18-12-14(5-8-16(18)21)4-3-11-26-20(23)10-7-15-6-9-17(22)19(13-15)25-2/h3-10,12-13,21-22H,11H2,1-2H3/b4-3+,10-7+

InChl Key

PGLIMMMHQDNVRS-YZQQHVNFSA-N

WGK Germany

P210-P231 + P232-P240-P241-P280-P335 + P334-P370 + P378-P402 + P404 LINK

RID/ADR

UN1309 - class 4.1 - PG 2 - Aluminum powder, coated

HS Code Reference

2918990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:63644-62-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

31359717

Abstract

Ten batches of Angelica sinensis from three producing areas( Tuoxiang,Minxian and Weiyuan of Gansu province) were selected as the research objects,and processed into raw A. sinensis,A. sinensis with alcohol,and A. sinensis with soil respectively through the standard processing methods. Ultra-high performance liquid chromatography( UPLC) was used to establish fingerprint for three processed products of A. sinensis,and determine the contents of 9 phenolic acids and phthalide compounds. The similarity was analyzed with Similarity Evaluation System for Chromatographic Fingerprint of Traditional Chinese Medicine,which showed that the chromatographic peaks of the same processed samples of A. sinensis were basically similar,with all similarities greater than 0. 950. The difference between different processed products and their control spectra was not obvious,with all similarities also higher than 0. 950.On the basis of using principal component analysis( PCA) and OPLS-DA to seek the difference components between groups,the improved distance coefficient method can be used to effectively distinguish the three processed products of A. sinensis by fingerprint similarity. At the same time,the determination method of nine phenolic acids and phthalide in A. sinensis was established by UPLC,and the comparison between different processed products was carried out. The results showed that the content of various components was changed as compared with the raw A. sinensis. The contents of coniferyl ferulate and ligustilide in the A. sinensis with alcohol were increased significantly,and the content of coniferyl ferulate was obviously increased in A. sinensis with soil. The method established in this paper can effectively distinguish different processed products of A. sinensis and determine the content of the main components in them.

KEYWORDS

Angelica sinensis; determination of multi-component content; fingerprint; principal component analysis; processed products; quality standard

Title

UPLC fingerprint and multi-components content determination of different processed products of Angelica sinensis

Author

Yan WH1, Cao HH1, Guo S1, Gu LY1, Hu W1, Cheng M1, Bai DT2, Chen J2, Mao CQ1, Li L1, Lu TL1.

Publish date

2019 Jun

PMID

28886520

Abstract

A rapid and simple LC-MS/MS method was developed and validated for the simultaneous determination of coniferyl ferulate (CF) and its metabolite coniferyl alcohol (CA) using bavachromene as an internal standard (IS). A TSQ Quantum Access mass spectrometer was operated under selected-reaction monitoring mode using negative electrospray ionization. Extraction with ether was used in sample preparation. The plasma samples were prepared and then chromatographed on a Phenomenex Luna C18 column (2.1mm×50mm, 1.7μm; Torrance, USA) at 35°C, using acetonitrile: water (65:35, v/v) in an isocratic mode at a flow rate of 0.3mL/min. Method validation was performed as per the FDA guidelines and calibration curves showed good linearity over the concentration range of 2.5-1000ng/mL for both CF and CA. The intra- and inter-day precision and accuracy were within the acceptable limits. The developed assay was successfully applied to a pharmacokinetic study of CA in rats.

Copyright © 2017 Elsevier B.V. All rights reserved.

KEYWORDS

Coniferyl alcohol; Coniferyl ferulate; LC-MS/MS; Pharmacokinetic study

Title

Development of a sensitive LC-MS/MS method for quantification of coniferyl ferulate and its metabolite coniferyl alcohol in rat plasma: Application to a pharmacokinetic study.

Author

Dai X1, Pang L2, Zhang Z3, Yang C3, Li Y4.

Publish date

2017 Nov 30

PMID

26521448

Abstract

A quantitative analysis method of multi-components with a single marker (QAMS) for simultaneous determination of six marker compounds (one from phenolic acids and five from phthalides) in Chuanxiong Rhizoma was established by applying HPLC and using butylidenephthalide as the internal reference substance. And also the feasibility and accuracy of the established method for quality evaluation and application of Chuanxiong Rhizoma were investigated and validated. The analysis was performed with the mobile phase consisting of acetonitrile – 0.2% aqueous formic acid. The flow rate was 1.0 mL . min-1 and the column temperature was maintained at 30 °C. The detection wavelengths were set at 252 nm (for ferulic acid, Z-ligustilide, and butylidenephthalide) and 266 nm (for senkyunolide I, senkyunolide A, and coniferyl ferulate), separately, and 20 µL was injected for analysis with gradient elution. The results showed that there were no significant differences observed between the HPLC-QAMS method and the external standard method (RSD <5%). The relative correction factors were credible (RSD < 5%) in changed chromatographic conditions. The established HPLC-QAMS method can be accurately used for simultaneously evaluating and controlling the quality of Chuanxiong Rhizoma with multi-components.

Title

Establishment and application of HPLC-QAMS for quality evaluation of Chuanxiong Rhizoma]

Author

Qiao FX, Cai H, Tu PF, Pei K, Song XQ.

Publish date

2015 Jun