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Coryneine

$608

  • Brand : BIOFRON

  • Catalogue Number : BN-O1519

  • Specification : 98%(HPLC)

  • CAS number : 7224-66-0

  • Formula : C11H18NO2+

  • Molecular Weight : 196.27

  • PUBCHEM ID : 165581

  • Volume : 10mg

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Catalogue Number

BN-O1519

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

196.27

Appearance

Botanical Source

Structure Type

Category

SMILES

C[N+](C)(C)CCC1=CC(=C(C=C1)O)O

Synonyms

Coryneine/Dopamine methiodide/2-(3,4-dihydroxyphenyl)-n,n,n-trimethylethanaminium/Quaternary dopamine

IUPAC Name

2-(3,4-dihydroxyphenyl)ethyl-trimethylazanium

Density

Solubility

Flash Point

Boiling Point

Melting Point

InChl

InChl Key

VDTBORSEFUUDTP-UHFFFAOYSA-O

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:7224-66-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

26891456

Abstract

A multifunctional hydrogel that combines the dual functionality of both antifouling and antimicrobial capacities holds great potential for many bioapplications. Many approaches and different materials have been employed to synthesize such a material. However, a systematic study, including in vitro and in vivo evaluation, on such a material as wound dressings is highly scarce at present. Herein, we report on a new strategy that uses catecholic chemistry to synthesize antimicrobial silver nanoparticles impregnated into antifouling zwitterionic hydrogels. For this purpose, hydrophobic dopamine methacrylamide monomer (DMA) was mixed in an aqueous solution of sodium tetraborate decahydrate and DMA monomer became soluble after increasing pH to 9 due to the complexation between catechol groups and boron. Then, cross-linking polymerization of zwitterionic monomer was carried out with the solution of the protected dopamine monomer to produce a new hydrogel. When this new hydrogel comes in contact with a silver nitrate solution, silver nanoparticles (AgNPs) are formed in its structure as a result of the redox property of the catechol groups and in the absence of any other external reducing agent. The results obtained from TEM and XRD measurements indicate that AgNPs with diameters of around 20 nm had formed within the networks. FESEM images confirmed that the silver nanoparticles were homogeneously incorporated throughout the hydrogel network, and FTIR spectroscopy demonstrated that the catechol moiety in the polymeric backbone of the hydrogel is responsible for the reduction of silver ions into the AgNPs. Finally, the in vitro and in vivo experiments suggest that these mussel-inspired, antifouling, antibacterial hydrogels have great potential for use in wound healing applications.

Title

In Situ Synthesis of Antimicrobial Silver Nanoparticles Within Antifouling Zwitterionic Hydrogels by Catecholic Redox Chemistry for Wound Healing Application

Author

Amin GhavamiNejad 1, Chan Hee Park 1, Cheol Sang Kim 1

Publish date

2016 Mar 14

PMID

6449223

Abstract

1 Coryneine is 2.7 times as active as cinobufotenine on the frog rectus but on the guinea-pig ileum cinobufotenine is 1.5 times as active as coryneine. Cinobufotenine is a potent stimulant of parasympathetic ganglia and its effect are competitively antagonized by hexamethonium. 2 The effects of pH on activity relative to a standard whose ionisation is constant (Me4+N or the trimethylammonium analogue of tryptamine) are consistent with the phenate form being weaker than the phenolic form but the changes are smaller than with coryneine because cinobufotenine is a weaker acid. 3 The hydroxyl group makes a large contribution to activity. Cinobufotenine is 9 times as active as the analogue without a hydroxyl on the frog rectus and 12 times as active as it on the ileum. The 5-methoxy analogue is an antagonist on the frog rectus and a very weak partial agonist on the ileum. 4 Cinobufotenine and the quaternary derivative of tryptamine have less than one-thousandth of the activity of 5-hydroxytryptamine on the rat fundus strip.

Title

A Comparison of Cinobufotenine (The Quaternary Derivative of 5-HT) and Some Related Compounds With Coryneine (The Quaternary Derivative of Dopamine) on the Frog Rectus, Guinea-Pig Ileum and Rat Fundus Strip Preparations

Author

R B Barlow, K N Burston

Publish date

1980 Aug

PMID

7492984

Abstract

The mode of the neuromuscular blocking action of coryneine (a quaternary ammonium derivative of dopamine) derived from aconite root was investigated in isolated phrenic nerve-diaphragm muscles and denervated diaphragm muscles of mice. Coryneine (20-150 microM) blocked the nerve-evoked twitch response without affecting the contraction evoked by electrical stimulation of the muscle. The blocking effect was reversed by neostigmine, a cholinesterase inhibitor. The electrical charge-response curve on depolarization produced by iontophoretically applied acetylcholine (ACh) at the endplate regions in normal muscles was shifted to the right on decreasing the maximal response by 40 microM coryneine. The double-reciprocal plot revealed that coryneine reduced the apparent affinity of ACh for its receptor on decreasing the maximal response. Coryneine (20 microM-2mM) itself depolarized the endplate membrane and this effect was reversibly suppressed by 1 and 5 microM pancuronium. Coryneine 30 microM-10mM) produced contractions of denervated muscles in a concentration-dependent manner and the effects were reduced by 70nM pancuronium. These results indicate that coryneine is a depolarizing agent and a mixed-type competitive and noncompetitive neuromuscular blocker.

Title

Depolarizing Neuromuscular Blocking Action of Coryneine Derived From Aconite Root in Isolated Mouse Phrenic Nerve-Diaphragm Muscles

Author

M Kimura 1, I Kimura, M Muroi, H Nojima, P V Diwan

Publish date

1995 May;


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