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Corynoline

$143

  • Brand : BIOFRON

  • Catalogue Number : BF-C2024

  • Specification : 98%

  • CAS number : 18797-79-0

  • Formula : C21H21NO5

  • Molecular Weight : 367.399

  • PUBCHEM ID : 177014

  • Volume : 20mg

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Catalogue Number

BF-C2024

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

367.399

Appearance

White crystalline powder

Botanical Source

Corydalis bungeana

Structure Type

Alkaloids

Category

Standards;Natural Pytochemical;API

SMILES

CC12C(CC3=CC4=C(C=C3C1N(CC5=C2C=CC6=C5OCO6)C)OCO4)O

Synonyms

(11S,13R,14R)-corynoline/13-Methylchelidonine/13-methyl-chelidonine/Corynoline/[1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol, 5b,6,7,12b,13,14-hexahydro-5b,13-dimethyl-, (5bR,6S,12bR)-

IUPAC Name

(1R,12S,13R)-13,24-dimethyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-2,4(8),9,14(22),15,17(21)-hexaen-12-ol

Density

1.4±0.1 g/cm3

Solubility

Methanol; Dichloromethane; Chloroform; DMF

Flash Point

258.7±30.1 °C

Boiling Point

504.2±50.0 °C at 760 mmHg

Melting Point

217-218ºC

InChl

InChI=1S/C21H21NO5/c1-21-14-3-4-15-19(27-10-24-15)13(14)8-22(2)20(21)12-7-17-16(25-9-26-17)5-11(12)6-18(21)23/h3-5,7,18,20,23H,6,8-10H2,1-2H3/t18-,20+,21-/m0/s1

InChl Key

IQUGPRHKZNCHGC-TYPHKJRUSA-N

WGK Germany

RID/ADR

HS Code Reference

2932900000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:18797-79-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

28486213

Abstract

Corynoline, isolated from Corydalis bungeana Turcz, has been reported to possess anti-inflammatory and antibacterial activities. In this study, we aimed to explore the treatment effect of corynoline on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. In the present study, the signaling pathways were measured by Western blot analysis. The levels of inflammatory cytokines were measured by enzyme-linked immunosorbent assays (ELISA). Additionally, the effects of corynoline on LPS-induced myeloperoxidase (MPO) activity was examined. The results showed that corynoline markedly inhibited LPS-induced neutrophils influx, MPO activity, and inflammatory cytokines IL-1β, TNF-α and IL-6 release. Corynoline also attenuated lung histopathological changes induced by LPS. Furthermore, corynoline inhibited LPS-induced NF-κB activation. In addition, corynoline up-regulated the expression of Nrf2 and HO-1 in a dose-dependent manner. The data suggest that corynoline has a treatment effect on LPS-induced ALI in mice by inhibiting inflammatory response.

KEYWORDS

Corynoline; LPS; Lung injury; Nrf2.

Title

Corynoline Attenuates LPS-induced Acute Lung Injury in Mice by Activating Nrf2

Author

Yan Liu 1 , Man Song 2 , Guangfa Zhu 3 , Xin Xi 2 , Keng Li 1 , Chunting Wu 2 , Lixue Huang 2

Publish date

2017 Jul

PMID

29748730

Abstract

Corynoline, a bioactive compound isolated from Corydalis bungeana Turcz., has been known to have anti-inflammatory activity. However, its effects on the inflammation of the cardiovascular system have not been reported yet. The aim of this study was to investigate the anti-inflammatory effects of corynoline on lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells (HUVECs). The results showed that LPS significantly increased the expression of VCAM-1 and ICAM-1. The production of cytokines TNF-α and IL-8 was also up-regulated by LPS. However, these increases were concentration-dependently suppressed by the treatment of corynoline. To investigate the anti-inflammatory mechanism of corynoline, we checked the activation of NF-κB and the expression of Nrf2. The results showed that LPS-induced NF-κB activation was suppressed by corynoline. The expression of Nrf2 and HO-1 was up-regulated by the treatment of corynoline. Knockdown of Nrf2 could reverse the anti-inflammatory effects of corynoline. In conclusion, the results indicated that corynoline exhibited anti-inflammatory activity by activating Nrf2.

KEYWORDS

Corynoline; LPS; Lung injury; Nrf2.

Title

Corynoline Exhibits Anti-inflammatory Effects in Lipopolysaccharide (LPS)-Stimulated Human Umbilical Vein Endothelial Cells Through Activating Nrf2

Author

Bin Liu 1 , Kai Su 2 , Jiaxin Wang 3 , Jingjing Wang 3 , Zhuoyuan Xin 4 , Fan Li 4 , Yunhe Fu 5 6

Publish date

2018 Oct

Abstract

Corydalis bungeana Turcz. is an anti-inflammatory medicinal herb used widely in traditional Chinese medicine for upper respiratory tract infections. It is demonstrated that corynoline is its active anti-inflammatory component. The nuclear factor-erythroid-2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway and the mitogen-activated protein kinase (MAPK) pathway play important roles in the regulation of inflammation. In this study, we investigated the potential anti-inflammatory mechanism of corynoline through modulation of Nfr2 and MAPKs. Lipopolysaccharide (LPS)-activated RAW264.7 cells were used to explore modulatory role of NO production and the activation of signaling proteins and transcription factors using nitrite assay, Western bloting and qPCR. Treatment with corynoline reduced production of nitric oxide (NO) and the protein and mRNA levels of inducible nitric oxide (iNOS) and cyclooxygenase-2 (COX-2) Treatment also significantly increased the expression of Nrf2, quinone oxidoreductase 1 (NQO1) and hemeoxygenase-1 (HO-1) at the mRNA and protein levels, which demonstrated that corynoline may protect cells from inflammation through the Nrf2/ARE pathway In addition, corynoline suppressed the expression of inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), at the mRNA and protein levels. Furthermore, molecular data revealed that corynoline inhibited lipopolysaccharide-stimulated phosphorylation of c-jun NH2-terminal kinase (JNK) and p38. Taken together, these results suggest that corynoline reduces the levels of pro-inflammatory mediators, such as iNOS, COX-2, TNF-α and IL-1β, by suppressing extracellular signal-regulated kinase 1/2 (ERK) and p38 phosphorylation in RAW264.7 cells, which is regulated by the Nrf2/ARE pathway. These findings reveal part of the molecular basis for the anti-inflammatory properties of corynoline.

KEYWORDS

MAPKs; Nrf2; anti-inflammation; corynoline.

Title

Corynoline Isolated From Corydalis Bungeana Turcz. Exhibits Anti-Inflammatory Effects via Modulation of Nfr2 and MAPKs

Author

Chunjuan Yang 1 2 , Chengyue Zhang 3 , Zhibin Wang 4 5 , Zhenqiu Tang 6 , Haixue Kuang 7 , Ah-Ng Tony Kong 8

Publish date

2016 Jul 27


Description :

Corynoline, isolated from Corydalis incise (Papaveraceae), is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC50 of 30.6 μM[1]. Corynoline exhibits anti-inflammatory activity by activating Nrf2[2].