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Coumarin

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-C3017

  • Specification : 98%

  • CAS number : 91-64-5

  • Formula : C9H6O2

  • Molecular Weight : 146.14

  • PUBCHEM ID : 323

  • Volume : 25mg

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Catalogue Number

BF-C3017

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

146.14

Appearance

White crystalline powder

Botanical Source

herbs of Melilotus officinalis

Structure Type

Phenylpropanoids

Category

Standards;Natural Pytochemical;API

SMILES

C1=CC=C2C(=C1)C=CC(=O)O2

Synonyms

Kumarin/Rattex/CUMARIN/chromen-2-one/COUMARINE/Coumarin

IUPAC Name

chromen-2-one

Density

1.2±0.1 g/cm3

Solubility

Methanol

Flash Point

118.3±16.1 °C

Boiling Point

298.0±0.0 °C at 760 mmHg

Melting Point

68-73 °C(lit.)

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2932200000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:91-64-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

9161499

Abstract

Coumarin is a drug which is extensively used to treat lymphedema. We report two cases of acute hepatitis probably due to coumarin. Two women, 40 year and 45 year-old, were treated with 90 mg/d of coumarin for 5 months. Clinical features included jaundice, pruritus, and diarrhea. A marked increase in serum aminotransferases was observed (ALT: 30 and 100 times the upper limit of normal, respectively). Coumarin withdrawal was rapidly followed by a favorable outcome in both cases. Rechallenge in one case induced a relapse of symptoms and liver test abnormalities. Coumarin can induce acute cytolytic hepatitis.

Title

[Acute cytolytic hepatitis caused by coumarin. 2 cases].

Author

Koch S1, Beurton I, Bresson-Hadni S, Monnot B, Hrusovsky S, Becker MC, Vanlemmens C, Carbillet JP, Miguet JP.

Publish date

1997

PMID

2078993

Title

The pharmacology, metabolism, analysis, and applications of coumarin and coumarin-related compounds.

Author

Egan D1, O'Kennedy R, Moran E, Cox D, Prosser E, Thornes RD.

Publish date

1990

PMID

32120972

Abstract

In order to facilitate the development of the green subcritical water chromatography technique for vanillin and coumarin, the stability of the compounds under subcritical water conditions was investigated in this work. In addition, their extraction from natural products was also studied. The stability experiments were carried out by heating the mixtures of vanillin and water or coumarin and water at temperatures ranging from 100 °C to 250 °C, while subcritical water extractions (SBWE) of both analytes from vanilla beans and whole tonka beans were conducted at 100 °C to 200 °C. Analyte quantification for both stability and extraction studies was carried out by HPLC. After heating for 60 min, vanillin was found to be stable in water at temperatures up to 250 °C. While coumarin is also stable at lower temperatures such as 100 °C and 150 °C, it undergoes partial degradation after heating for 60 min at 200 °C and higher. The results of this stability study support green subcritical water chromatographic separation and extraction of vanillin and coumarin at temperatures up to 150 °C. The SBWE results revealed that the extraction efficiency of both analytes from vanilla beans and tonka beans is significantly improved with increasing temperature.

KEYWORDS

HPLC; SBWE; coumarin; stability; subcritical water extraction; tonka beans; vanilla beans; vanillin

Title

Stability and Extraction of Vanillin and Coumarin under Subcritical Water Conditions.

Author

Doctor N1, Parker G1, Vang K1, Smith M1, Kayan B2, Yang Y1.

Publish date

2020 Feb 27


Description :

Coumarin is the primary bioactive ingredient in Radix Glehniae, named Beishashen in China, which possesses many pharmacological activities, including anticancer, anti-inflammation and antivirus activities.