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Crocin I


  • Brand : BIOFRON

  • Catalogue Number : BF-C3024

  • Specification : 98%

  • CAS number : 42553-65-1

  • Formula : C44H64O24

  • Molecular Weight : 976.96

  • Volume : 20mg

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Crocus sativus,Gardenia jasminoides

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WGK Germany


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Personal Projective Equipment

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For Reference Standard and R&D, Not for Human Use Directly.

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provides coniferyl ferulate(CAS#:42553-65-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

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Gastroprotective effect of crocin in ethanol-induced gastric injury in rats. PUMID/DOI:25637687 Chem Biol Interact. 2015 Mar 5;229:26-35. The present study investigated the gastroprotective effect of Crocin in ethanol-induced gastric injury in rats. Rats were allocated into a normal group, an ulcer group, a Crocin-treated group, an ulcer group pretreated with Crocin, and an ulcer group pretreated with omeprazole as a reference anti-ulcer drug. Rats were sacrificed 3h after ethanol administration. Prophylactic administration of Crocin (50mg/kg/day, i.p.) for 3 consecutive days before the administration of 70% ethanol (10 ml/kg, orally) resulted in significant gastroprotection compared to ethanol-ulcerated rats as manifested by significant reduction in the gastric ulcer index. Crocin pretreatment increased ethanol-lowered levels of gastric juice mucin and mucosal prostaglandin E2 (PGE2) and interleukin-6 (IL-6). Moreover, Crocin significantly decreased ethanol-elevated tumor necrosis factor-alpha (TNF-α) level, myeloperoxidase activity and heat shock protein 70 mRNA and protein levels. It also restored ethanol-altered mucosal levels of glutathione, malondialdehyde and superoxide dismutase activity. Furthermore, Crocin-pretreatment alleviated ethanol-induced mucosal apoptosis as revealed by significant down-regulation of cytochrome c and caspase-3 mRNA expression, significant decrease in caspase-3 activity and mitigated DNA fragmentation as indicated by significant decrements in comet parameters. The protective efficacy of Crocin was further supported by histological assessment. No significant difference was observed between Crocin and omeprazole (20mg/kg orally 1h before ethanol administration) regarding their mucin-secretagogue and antioxidant effects, as well as their effects on TNF-α, IL-6 and cytochrome c. On the other hand, omeprazole was superior in enhancing PGE2 level and in alleviating neutrophil infiltration, caspase-3 activation and DNA fragmentation. Conclusively, Crocin protects rat gastric mucosa against ethanol-induced injury via anti-inflammatory, anti-oxidative, anti-apoptotic and mucin-secretagogue mechanisms that are probably mediated by enhanced PGE2 release. Anti-asthma potential of crocin and its effect on MAPK signaling pathway in a murine model of allergic airway disease. PUMID/DOI:25753844 Immunopharmacol Immunotoxicol. 2015 Jun;37(3):236-43. CONTEXT:Crocin, a diterpenoid glucoside, has multitudinous activities such as anti-inflammation, anti-allergy, anti-oxidation and relaxing smooth muscles.OBJECTIVE:In this study, the potential of Crocin as an anti-asthma agent was investigated in a murine model.MATERIALS AND METHODS:BALB/c mice were sensitized and challenged by ovalbumin (OVA) to induce allergic airway inflammation, with Crocin administered one hour before every OVA challenge. Airway hyper-reactivity was evaluated by lung function analysis systems. Leukocyte counts in bronchoalveolar lavage fluid (BALF) were measured by a hemocytometer and Diff-Quick-stained smears. Lung tissues were stained with hematoxylin-eosin, Congo red and methylene blue for histopathological inspection. Inflammatory mediators in serum, BALF and lung were measured by ELISA or RT-PCR. Effects of Crocin on MAPK signaling pathways were investigated by western blot analysis.RESULTS:Crocin significantly suppressed airway inflammation and hyper-reactivity, reduced levels of BALF interleukin (IL-4), IL-5, IL-13 and tryptase, lung eosinophil peroxidase and serum OVA-specific IgE, and inhibited the expression of lung eotaxin, p-ERK, p-JNK and p-p38 in the OVA-challenged mice.CONCLUSIONS:These results demonstrated that the suppression of Crocin on airway inflammation and hyper-reactivity in a murine model, thus Crocin might have a great potential to be a candidate for the treatment of asthma. Ovarian cancer HO-8910 cell apoptosis induced by crocin in vitro. PUMID/DOI:25920253 Nat Prod Commun. 2015 Feb;10(2):249-52. The effect and mechanism of ovarian cancer HO-8910 cell apoptosis induced by Crocin.MTT assay was performed to detect the inhibitory action of Crocin on the proliferation of HO-8910 cells. Flow cytometry was used to test the cell cycle distribution and apoptosis rate of ovarian cancer HO-8910 cells. Western blot analysis was utilized to measure the levels of apoptotic proteins such as p53, Fas/APO-1, and Caspase-3. MTT analysis revealed that Crocin significantly inhibited the growth of HO-8910 cells. Additionally, flow cytometry illustrated that Crocin raised the proportion of HO-8910 cells in the G0/G1 phase and increased their apoptosis rate. Furthermore, Western blot analysis revealed that Crocin up-regulated the expression of p53, Fas/APO-1, and Caspase-3. The results of this study showed that Crocin can significantly inhibit the growth of HO-8910 cells and arrest them in the G0/G1 phase. Crocin can also promote ovarian cancer HO-8910 cell apoptosis, most likely by increasing p53 and Fas/APO-1 expression, and then activating the apoptotic pathway regulated by Caspase-3. Effect of crocin on oxidative stress in recovery from single bout of swimming exercise in rats. PUMID/DOI:26001290 Gen Physiol Biophys. 2015 May 22. Physical exercise could cause muscle and tissue damage due to increase in the formation of free oxygen radicals during exercise. The aim of the present study was to investigate the effect of Crocin on parameters associated with oxidative stress in recovery from acute swimming exercise in rats. Rats were divided into eight groups; Normal Control (NC: untreated and did not swim), Crocin Control (CC: received Crocin and did not swim), Exercise-1 (Exe-1: untreated and swam), Exercise-24 (Exe-24: untreated and swam), Exercise-48 (Exe-48: untreated and swam), Exercise+Crocin-1 (Exe-Cro-1: received Crocin and swam), Exercise+Crocin-24 (Exe-Cro-24: received Crocin and swam), Exercise+Crocin-48 (Exe-Cro-48: received Crocin and swam). AST, ALP, LDH, CK, XO enzymes levels increased after swimming in untreated and Crocin-treated groups, but there was a less increase in Crocin-treated groups. The highest MDA levels in serum were determined in Exe-1 compared with all other groups. There was significant difference between control and exercise groups in MDA level (p = 0.033). In contrast, there was significant difference between control and exercise groups in GSH level (p < 0.001). In addition, Crocin given to swimming rats significantly increased GSH levels (p < 0.05) and decreased MDA levels when compared with untreated exercise groups. In conclusion, Crocin is able to protect liver and skeletal muscle tissue against exercise-induced oxidative damage by preventing reactive oxygen species (ROS) production. Mechanism of hypolipidemic effect of crocin in rats: crocin inhibits pancreatic lipase.[ PUMID/DOI:16828739 Eur J Pharmacol. 2006 Aug 14;543(1-3):116-22. The hypolipidemic mechanism of Crocin, an active ingredient in Gardenia jasminoides Ellis and Crocus sativus L, was examined in rats. In diet-induced hyperlipidemic rats, a 10-day treatment with Crocin significantly reduced serum triglyceride, total cholesterol, low density lipoprotein (LDL) cholesterol and very low density lipoprotein (VLDL) cholesterol level in the daily dose range of 25 to 100 mg/kg. Results of the modified fat-loading method indicated that Crocin inhibited the absorption of fat and cholesterol and this inhibition is closely related to the hydrolysis of fat. In addition, the modified fat-balance method demonstrated that Crocin increased the fecal excretion of fat and cholesterol in rats, but had no inf