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Curcumenol

$78

  • Brand : BIOFRON

  • Catalogue Number : BF-C2004

  • Specification : 98%

  • CAS number : 19431-84-6

  • Formula : C15H22O2

  • Molecular Weight : 234.33

  • PUBCHEM ID : 167812

  • Volume : 20mg

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Catalogue Number

BF-C2004

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

-20℃

Molecular Weight

234.33

Appearance

White crystalline powder

Botanical Source

Curcuma phaeocaulis

Structure Type

Terpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1CCC2C13CC(=C(C)C)C(O3)(C=C2C)O

Synonyms

(1S,2S,5S,8R)-9-Isopropylidene-2,6-dimethyl-11-oxatricyclo[6.2.1.0]undec-6-en-8-ol/(3S,3aS,6R,8aS)-1,2,3,4,5,8a-hexahydro-3,8-dimethyl-5-(1-methylethylidene)-6H-3a,6-epoxyazulen-6-ol/(3S,3aS,8aS)-3,8-dimethyl-5-(propan-2-ylidene)-1,2,3,4,5,8a-hexahydro-6H-3a,6-epoxyazulen-6-ol/(3S,3aS,6R,8aS)-3,8-dimethyl-5-(propan-2-ylidene)-1,2,3,4,5,8a-hexahydro-6H-3a,6-epoxyazulen-6-ol/Curcumenol/(1S,2S,5S,8R)-9-isopropylidene-2,6-dimethyl-11-oxatricyclo[6.2.1.01,5]undec-6-en-8-ol/3,8-dimethyl-5-(1-methylethylidene)-,(3S,3aS,6R,8aS)6H-3a,6-Epoxyazulen-6-ol, 1,2,3,4,5,8a-hexahydro-3,8-dimethyl-5-(1-methylethylidene)-, (3S,3aS,6R,8aS)-/(3S,3alphaS,6R,8alphaS)-1,2,3,4,5,8alpha-Hexahydro-3,8-dimethyl-5-(1-methylethylidene)-6H-3alpha,6-epoxyazulen-6-ol/6H-3a,6-Epoxyazulen-6-ol,1,2,3,4,5,8a-hexahydro

IUPAC Name

(1S,2S,5S,8R)-2,6-dimethyl-9-propan-2-ylidene-11-oxatricyclo[6.2.1.01,5]undec-6-en-8-ol

Density

1.1±0.1 g/cm3

Solubility

Methanol

Flash Point

146.7±22.1 °C

Boiling Point

349.3±42.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C15H22O2/c1-9(2)13-8-14-11(4)5-6-12(14)10(3)7-15(13,16)17-14/h7,11-12,16H,5-6,8H2,1-4H3

InChl Key

ISFMXVMWEWLJGJ-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2938900000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:19431-84-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

29543859

Abstract

Curcuma longa possesses powerful antifungal activity, as demonstrated in many studies. In this study, the antifungal spectrum of Curcuma longa alcohol extract was determined, and the resulting EC50 values (mg/mL) of its extract on eleven fungi, including Fusarium graminearum, Fusarium chlamydosporum, Alternaria alternate, Fusarium tricinctum, Sclerotinia sclerotiorum, Botrytis cinerea, Fusarium culmorum, Rhizopus oryzae, Cladosporium cladosporioides, Fusarium oxysporum and Colletotrichum higginsianum, were 0.1088, 0.1742, 0.1888, 0.2547, 0.3135, 0.3825, 0.4229, 1.2086, 4.5176, 3.8833 and 5.0183, respectively. Among them, F. graminearum was selected to determine the inhibitory effects of the compounds (including curdione, isocurcumenol, curcumenol, curzerene, β-elemene, curcumin, germacrone and curcumol) derived from Curcuma longa. In addition, the antifungal activities of curdione, curcumenol, curzerene, curcumol and isocurcumenol and the synergies of the complexes of curdione and seven other chemicals were investigated. Differential proteomics of F. graminearum was also compared, and at least 2021 reproducible protein spots were identified. Among these spots, 46 were classified as differentially expressed proteins, and these proteins are involved in energy metabolism, tRNA synthesis and glucose metabolism. Furthermore, several fungal physiological differences were also analysed. The antifungal effect included fungal cell membrane disruption and inhibition of ergosterol synthesis, respiration, succinate dehydrogenase (SDH) and NADH oxidase.

Title

Antifungal activity, main active components and mechanism of Curcuma longa extract against Fusarium graminearum

Author

Ciqiong Chen, Data curation, Formal analysis, Validation, Visualization, Writing - original draft, Writing - review & editing,# Li Long, Conceptualization, Investigation, Supervision,# Fusheng Zhang, Data curation, Software, Visualization, Qin Chen, Investigation, Methodology, Cheng Chen, Supervision, Xiaorui Yu, Investigation, Qingya Liu, Visualization, Jinku Bao, Funding acquisition, Resources, and Zhangfu Long, Conceptualization, Funding acquisition, Methodology*

Publish date

2018 Mar 15


Description :

Curcumenol is one of constituents in the plants of medicinally important genus of Curcuma[1].