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Curcumin

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-C3012

  • Specification : 99%

  • CAS number : 458-37-7

  • Formula : C21H20O6

  • Molecular Weight : 368.38

  • PUBCHEM ID : 969516

  • Volume : 25mg

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Catalogue Number

BF-C3012

Analysis Method

HPLC,NMR,MS

Specification

99%

Storage

-20℃

Molecular Weight

368.38

Appearance

Yellow crystalline powder

Botanical Source

Curcuma longa,Curcuma wenyujin,Curcuma phaeocaulis

Structure Type

Phenolics

Category

Standards;Natural Pytochemical;API

SMILES

COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O

Synonyms

Diferulylmethane/Turmeric yellow/curcuma/diferuloylmethane/Natural Yellow 3/gelbwurz/(1E,4Z,6E)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one/(1E,4Z,6E)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one/1,4,6-Heptatrien-3-one, 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-, (1E,4Z,6E)-/curouma/halad/souchet/kurkumin/haidr/Curcumin/(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione/(E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione

IUPAC Name

(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione

Density

1.3±0.1 g/cm3

Solubility

Methanol

Flash Point

209.7±23.6 °C

Boiling Point

593.2±50.0 °C at 760 mmHg

Melting Point

183 °C

InChl

InChl Key

WGK Germany

RID/ADR

HS Code Reference

2932990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:458-37-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

27325106

Abstract

Breast cancer is among the most common malignant tumors. It is the second leading cause of cancer mortality among women in the United States. Curcumin, an active derivative from turmeric, has been reported to have anticancer and chemoprevention effects on breast cancer. Curcumin exerts its anticancer effect through a complicated molecular signaling network, involving proliferation, estrogen receptor (ER), and human epidermal growth factor receptor 2 (HER2) pathways. Experimental evidence has shown that curcumin also regulates apoptosis and cell phase-related genes and microRNA in breast cancer cells. Herein, we review the recent research efforts in understanding the molecular targets and anticancer mechanisms of curcumin in breast cancer.

KEYWORDS

breast cancer; curcumin; natural compound; signaling pathways

Title

Curcumin in Treating Breast Cancer: A Review

Author

Yiwei Wang 1 2 , Jiayi Yu 2 , Ran Cui 2 , Jinjin Lin 1 , Xianting Ding 3

Publish date

2016 Dec

PMID

28074653

Abstract

Curcumin is a constituent (up to ∼5%) of the traditional medicine known as turmeric. Interest in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led to their extensive investigation. Curcumin has recently been classified as both a PAINS (pan-assay interference compounds) and an IMPS (invalid metabolic panaceas) candidate. The likely false activity of curcumin in vitro and in vivo has resulted in >120 clinical trials of curcuminoids against several diseases. No double-blinded, placebo controlled clinical trial of curcumin has been successful. This manuscript reviews the essential medicinal chemistry of curcumin and provides evidence that curcumin is an unstable, reactive, nonbioavailable compound and, therefore, a highly improbable lead. On the basis of this in-depth evaluation, potential new directions for research on curcuminoids are discussed.

KEYWORDS

breast cancer; curcumin; natural compound; signaling pathways

Title

The Essential Medicinal Chemistry of Curcumin

Author

Kathryn M Nelson 1 , Jayme L Dahlin 2 , Jonathan Bisson 3 , James Graham 3 , Guido F Pauli 3 4 , Michael A Walters 1

Publish date

2017 Mar 9

PMID

29206254

Abstract

Curcumin is a polyphenol found in turmeric (Curcuma longa), used as a spice, in food coloring, and as a traditional herbal medicine. It has been shown that curcumin has health benefits such as antioxidant, anti-inflammatory, and anticancer properties, improvement of brain function, and control of obesity and diabetes. However, native curcumin easily degrades and has low oral bioavailability, and a recent report has expressed doubt about curcumin’s various effects. To overcome its low bioavailability, various curcumin formulations with enhanced bioavailability are currently being developed. This review discusses the chemistry, metabolism, and absorption of curcumin, to which various reported health benefits have been ascribed, as well as curcumin’s degradation products and metabolites and their possible functions. Moreover, the research trend towards the obesity- and diabetes-preventing/suppressing aspects of curcumin and the latest case studies on highly water-dispersible and bioavailable curcumin formulations will be discussed. We summarize the challenges concerning research on curcumin’s health benefits as follows: clarifying the relationship between curcumin’s health benefits and the formation of curcumin-derived oxidation and degradation products and metabolites, determining whether curcumin itself or other components in turmeric are responsible for its effects, and conducting further human trials in which multiple research groups employ the same samples and conditions. High-bioavailability formulations would be useful in such future studies.

Title

Curcumin as a Functional Food-Derived Factor: Degradation Products, Metabolites, Bioactivity, and Future Perspectives

Author

Takanori Tsuda 1

Publish date

2018 Feb 21


Description :

Curcumin is a natural phenolic compound with diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin is an inhibitor of p300 histone acetylatransferase ((HATs)) and also shows inhibitory effects on NF-κB and MAPKs.