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Curdione

$113

  • Brand : BIOFRON

  • Catalogue Number : BF-C2005

  • Specification : 98%

  • CAS number : 13657-68-6

  • Formula : C15H24O2

  • Molecular Weight : 236.35

  • PUBCHEM ID : 6441391

  • Volume : 20mg

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Catalogue Number

BF-C2005

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

236.35

Appearance

White crystalline powder

Botanical Source

Perilla frutescens,Curcuma wenyujin,Curcuma phaeocaulis,Curcuma kwangsiensis

Structure Type

Terpenoids

Category

Standards;Natural Pytochemical;API

SMILES

CC1CCC=C(CC(=O)C(CC1=O)C(C)C)C

Synonyms

(3R,6E,10S)-3-Isopropyl-6,10-dimethyl-6-cyclodecene-1,4-dione/N1432/Curdione/6-Cyclodecene-1,4-dione, 6,10-dimethyl-3-(1-methylethyl)-, (3R,6E,10S)-/neo-Curdione/Germacr-1(10)-ene-5,8-dione/(3S,10S)-3-Isopropyl-6,10-dimethyl-6-cyclodecene-1,4-dione/6-Cyclodecene-1,4-dione, 6,10-dimethyl-3-(1-methylethyl)-, (3S,10S)-

IUPAC Name

(3S,6E,10S)-6,10-dimethyl-3-propan-2-ylcyclodec-6-ene-1,4-dione

Density

0.9±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

130.4±24.9 °C

Boiling Point

347.6±42.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C15H24O2/c1-10(2)13-9-14(16)12(4)7-5-6-11(3)8-15(13)17/h6,10,12-13H,5,7-9H2,1-4H3/b11-6+/t12-,13-/m0/s1

InChl Key

KDPFMRXIVDLQKX-NHFJXKHHSA-N

WGK Germany

RID/ADR

HS Code Reference

2938900000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:13657-68-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

29543859

Abstract

Curcuma longa possesses powerful antifungal activity, as demonstrated in many studies. In this study, the antifungal spectrum of Curcuma longa alcohol extract was determined, and the resulting EC50 values (mg/mL) of its extract on eleven fungi, including Fusarium graminearum, Fusarium chlamydosporum, Alternaria alternate, Fusarium tricinctum, Sclerotinia sclerotiorum, Botrytis cinerea, Fusarium culmorum, Rhizopus oryzae, Cladosporium cladosporioides, Fusarium oxysporum and Colletotrichum higginsianum, were 0.1088, 0.1742, 0.1888, 0.2547, 0.3135, 0.3825, 0.4229, 1.2086, 4.5176, 3.8833 and 5.0183, respectively. Among them, F. graminearum was selected to determine the inhibitory effects of the compounds (including curdione, isocurcumenol, curcumenol, curzerene, β-elemene, curcumin, germacrone and curcumol) derived from Curcuma longa. In addition, the antifungal activities of curdione, curcumenol, curzerene, curcumol and isocurcumenol and the synergies of the complexes of curdione and seven other chemicals were investigated. Differential proteomics of F. graminearum was also compared, and at least 2021 reproducible protein spots were identified. Among these spots, 46 were classified as differentially expressed proteins, and these proteins are involved in energy metabolism, tRNA synthesis and glucose metabolism. Furthermore, several fungal physiological differences were also analysed. The antifungal effect included fungal cell membrane disruption and inhibition of ergosterol synthesis, respiration, succinate dehydrogenase (SDH) and NADH oxidase.

Title

Antifungal activity, main active components and mechanism of Curcuma longa extract against Fusarium graminearum

Author

Ciqiong Chen, Data curation, Formal analysis, Validation, Visualization, Writing - original draft, Writing - review & editing,# Li Long, Conceptualization, Investigation, Supervision,# Fusheng Zhang, Data curation, Software, Visualization, Qin Chen, Investigation, Methodology, Cheng Chen, Supervision, Xiaorui Yu, Investigation, Qingya Liu, Visualization, Jinku Bao, Funding acquisition, Resources, and Zhangfu Long, Conceptualization, Funding acquisition, Methodology*

Publish date

2018 Mar 15

PMID

30918282

Abstract

Ruyiping (RYP), a Chinese herbal formula, can remove toxin and clear nodular, showing ability of preventing postoperative recurrence of breast cancer. In this study, network was performed to predict possible targets, genes and pathways associated with RYP and breast cancer. Thin Layer Chromatography (TLC) and High Performance Liquid Chromatography (HPLC) were used to quantitatively study RYP formula and its single herbs. MTT methods, Luciferase reporter systems, zebrafish model and western blotting were respectively adopted to verify network prediction. Results showed that the quality of RYP could be controlled and icariin could be selected as mark ingredient; RYP expressed anti-breast tumor effects, which could be associated with inhibiting expression of Transforming Growth Factor β (TGFβ), promoting cells apoptosis and anti-angiogenesis. Parts of these results were consistent with network predictions in some degree, but not all. Network can help us narrow areas, focus on crucial factors, save money as well as time, but the results predicted by network should be confirmed by further experiments.

Title

Effects and possible mechanism of Ruyiping formula application to breast cancer based on network prediction

Author

Rui-Fang Xie,#1 Sheng Liu,#1 Ming Yang,1 Jia-Qi Xu,1 Zhi-Cheng Li,2 and Xin Zhoucorresponding author1

Publish date

2019 Mar 27.

PMID

29138518

Abstract

Germacrone, curdione, and furanodiene have been shown to be useful in the treatment of breast cancer but the pharmacological mechanism of action is unclear. In this paper, we explored a new method to study the molecular network and function of Traditional Chinese Medicine (TCM) herbs and their corresponding ingredients with bioinformatics tools, including PubChem Compound Database, BATMAN-TCM, SystemsDock, Coremine Medical, Gene ontology, and KEGG. Eleven targeted genes/proteins, 4 key pathways, and 10 biological processes were identified to participate in the mechanism of action in treating breast cancer with germacrone, curdione, and furanodiene. The information achieved by the bioinformatics tools was useful to interpretation the molecular mechanism for the treatment of germacrone, curdione, and furanodiene on breast cancers.

Title

Predicted molecular targets and pathways for germacrone, curdione, and furanodiene in the treatment of breast cancer using a bioinformatics approach

Author

Qi Kong,corresponding author1 Yong Ma,2 Jie Yu,3 and Xiuping Chen3

Publish date

2017 Nov 14


Description :

Curdione, one of the major sesquiterpene compounds from Rhizoma Curcumae, has been shown to exhibit multiple bioactive properties.IC50 value: 60-80 μMTarget:In vitro: The study of the influence of curdione on the hemorheological changes in blood stasis model rats and thrombolysis in vitro showed that curdione only possessed thrombolytic effect in dose of 0.235 g·L-1 and 2.35 g·L-1, but has not the notable activity of thrombolysis [1]. The effects of curdione on human platelet aggregation induced by thrombin (0.3 U/ml) were tested in vitro. Curdione preferentially inhibited PAF- and thrombin- induced platelet aggregation in a concentration-dependent manner (IC50: 60-80 μM), whereas much higher concentrations of curdione were required to inhibit platelet aggregation induced by ADP and AA. Curdione also inhibited P-selectin expression in PAF-activated platelets. Moreover, curdione caused an increase in cAMP levels and attenuated intracellular Ca2+ mobilization in PAF-activated platelets. In vivo: Curdione showed significant antithrombotic activity [2].