White crystalline powder
Stephania epigaea Lo/Alkaloid from Aristolochia indica, Chondodendron platyphyllum, Chondodendron tomentosum, Chondodendron toxicoferum, Cissampelos pareira, Cissampelos mucronata, Isolona pilosa, Pleogyne cunninghamii, Radix pareirae bravae, Paracyclea ochiaiana,
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
706.5±60.0 °C at 760 mmHg
213°; mp 221° in vacuo; mp 161°
HS Code Reference
Personal Projective Equipment
For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:436-05-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
The objective was to prepare neural models identifying relationships between formulation characteristics and pellet properties based on algorithmic approach of crucial variables selection and neuro-fuzzy systems application. The database consisted of information about 227 pellet formulations prepared by extrusion/spheronization method, with various model drugs and excipients. Cheminformatic description of excipients and model drugs was employed for numerical description of pellet formulations. Initial numbers of neural model inputs were up to around 3000. The inputs reduction procedure based on sensitivity analysis allowed to obtain less than 40 inputs for each model. The reduced models were subjects of fuzzy logic implementation resulting in logical rules tables providing human-readable rule sets applicable in future development of pellet formulations. Neural modeling enhanced knowledge about pelletization process and provided means for future computer-guided search for the optimal formulation.
Copyright © 2010 Elsevier B.V. All rights reserved.
Analysis of pellet properties with use of artificial neural networks.
Mendyk A1, Kleinebudde P, Thommes M, Yoo A, Szlęk J, Jachowicz R.
2010 Nov 20;
Two independent in vitro regeneration systems of the embryonic chick retina (E4-5) were used to study the mobilisation of intracellular calcium by the neurotransmitters acetylcholine (ACh) and glutamate, as measured by Fura-2 fluorescence changes. Retinal pigment epithelium (RPE) explants under the influence of basic fibroblast growth factor transdifferentiate into a retina-like tissue with normal laminar organisation, while rosetted spheres reaggregated from fully dispersed cells of the embryonic retina will achieve only an inferior tissue organisation, characterised by regions of an inverted retina [Layer et al., Neuroreport 12 (2001) A39-46]. ACh induced a pronounced Ca(2+) response in young explants, and a similar but less pronounced response in reaggregates; this response decreased almost entirely after 1 week in culture. In contrast, a Ca(2+) response to glutamate became detectable later, continuously increasing during this period. The response to ACh was strictly mediated by muscarinic ACh receptors (mAChRs), since it was inhibited by preincubation with atropine, but not tubocurarine; correspondingly, it was mimicked by muscarine, but not nicotine. Studies with mAChR blockers, preferentially acting on the m1-, m2-, or m3-receptor subtypes, suggested that the muscarine-induced Ca(2+) response is mediated by m1- and/or m3-type mAChRs, but not by the m2-type. These results show that (i) similar to the in vivo retina, in both a transdifferentiating and a reaggregating system an early muscarinic Ca(2+) response is active, which (ii) roughly parallels periods of cell proliferation, and (iii)-as evidenced by the reaggregates-does not depend on any tissue pre-organisation. In contrast, a response to glutamate becomes prominent only when tissue differentiation commences. This is the first demonstration of a physiological response in regenerating chick retinas, supporting their validity as models both of retinal development and regeneration.
Transient muscarinic calcium mobilisation in transdifferentiating as in reaggregating embryonic chick retinae.
Naruoka H1, Kojima R, Ohmasa M, Layer PG, Saito T.
2003 Jul 12;
The rates of inhibition of mouse acetylcholinesterase (AChE) (EC 188.8.131.52) by paraoxon, haloxon, DDVP, and enantiomers of neutral alkyl methylphosphonyl thioates and cationic alkyl methylphosphonyl thiocholines were measured in the presence and absence of AChE peripheral site inhibitors: gallamine, D-tubocurarine, propidium, atropine and derivatives of coumarin. All ligands, except the coumarins, at submillimolar concentrations enhanced the rates of inhibition by neutral organophosphorus compounds (OPs) while inhibition rates by cationic OPs were slowed down. When peripheral site ligand concentrations extended to millimolar, the extent of the enhancement decreased creating a bell shaped activation profile. Analysis of inhibition by DDVP and haloxon revealed that peripheral site inhibitors increased the second order reaction rates by increasing maximal rates of phosphylation.
The influence of peripheral site ligands on the reaction of symmetric and chiral organophosphates with wildtype and mutant acetylcholinesterases.
Radić Z1, Taylor P.
1999 May 14;