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Cyclobuxine D

$600

  • Brand : BIOFRON

  • Catalogue Number : BN-O1847

  • Specification : 98%(HPLC)

  • CAS number : 2241-90-9

  • Formula : C25H42N2O

  • Molecular Weight : 386.6

  • PUBCHEM ID : 260437

  • Volume : 20mg

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Catalogue Number

BN-O1847

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

386.6

Appearance

Botanical Source

Structure Type

Category

SMILES

CC(C1C(CC2(C1(CCC34C2CCC5C3(C4)CCC(C5=C)NC)C)C)O)NC

Synonyms

IUPAC Name

(1S,3R,6S,8R,11S,12S,14R,15S,16R)-12,16-dimethyl-6-(methylamino)-15-[(1S)-1-(methylamino)ethyl]-7-methylidenepentacyclo[9.7.0.01,3.03,8.012,16]octadecan-14-ol

Applications

Density

1.08g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

53.5ºC

Boiling Point

494.2ºC at 760mmHg

Melting Point

236-238ºC

InChl

InChI=1S/C11H12O2/c1-11(2)6-5-8-3-4-9(12)7-10(8)13-11/h3-7,12H,1-2H3

InChl Key

BSNZFQANPMIOIU-WZBMPAQFSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:2241-90-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

8372142

Abstract

Cyclobuxine is a steroidal alkaloid which was extracted from Buxus microphylla var. koreana Nakai. Extracts of Buxus microphylla var. koreana Nakai have been used as folk remedies of several diseases, including malaria and venereal diseases. In the present study, the possible protective effects of cyclobuxine against 60 min ischemia and subsequent 30 min reperfusion in isolated rat hearts were investigated. Ischemia induced a marked decline in contractile force and a gradual rise in resting tension. Reperfusion of the heart for 30 min resulted in a poor recovery of contractile force. When the heart was perfused in the presence of cyclobuxine (100 and 1000 ng/ml), a significant suppression of mechanical failure was seen. Ischemia also induced an immediate release of ATP metabolites and a release of creatine phosphokinase during reperfusion. Cyclobuxine inhibited the release of ATP metabolites, and slightly prevented the release of creatine phosphokinase during reperfusion. The ultrastructural damages induced by ischemia and subsequent reperfusion were significantly suppressed by cyclobuxine.

Title

Cyclobuxine protects the isolated rat heart from the myocardial injuries produced by ischemia and reperfusion

Author

J H Lee 1, J T Kwon, B H Cho, C K Moon

Publish date

1993 Aug;

PMID

14222888

Title

NUCLEIC ACID INTERACTIONS. V. EFFECTS OF CYCLOBUXINE

Author

H R MAHLER, G DUTTON

Publish date

1964 Oct;