White crystalline powder
Cytosin/Cytosinimine/Cytosine/4-aminopyrimidin-2-one/Cyt/Lamivudine Impurity 5/6-Aminopyrimidin-2(1H)-one
6-Aminopyrimidin-2(1H)-one is an organic compound that belongs to the class known as pyrimidones.
445.8ºC at 760 mmHg
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For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:71-30-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Epigenetic modifications of cytosine have been found to influence differently in many processes in biological systems. In order to investigate the differences in electron attachment to different epigenetic modifications of cytosine, we reported the A″ component of the integral cross section of electron scattering by cytosine (C) and its epigenetic modifications 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). Our results were obtained with the Schwinger multichannel method with pseudopotentials in the static-exchange (SE) and static-exchange plus polarization (SEP) approximations. In addition to the scattering results, we present electron attachment energies obtained through an empirical scaling relation for the five molecules. We observed three π* resonances for C, 5mC, and 5hmC and four for 5fC and 5caC, in both SE and SEP approximations. The cross sections show that the π* resonances of 5mC and 5hmC are located at higher energies than the resonances of C, while the resonances of 5fC and 5caC are located at lower energies. In order to investigate this shift in the resonances’ positions, we analyzed the π* lowest-lying orbitals and the electronic density over the molecules. Using the inductive and mesomeric effects, we were able to analyze the influence of each substituent over the molecule and on the resonances’ positions.
Substituents' effect in electron attachment to epigenetic modifications of cytosine.
Nunes FB1, Bettega MHF1, Sanchez SD1.
2017 Jun 28
Cytosine drives evolution of SARS-CoV-2.
Danchin A1, Marliere P2.
2020 Apr 14
The decay mechanism of S0 → S1 excited cytosine (Cyt) and the effect of substitution are studied combining jet-cooled spectroscopy (nanosecond resonant two-photon ionization (R2PI) and picosecond lifetime measurements) with CASPT2//CASSCF computations for eight derivatives. For Cyt and five derivatives substituted at N1, C5, and C6, rapid internal conversion sets in at 250-1200 cm-1 above the 000 bands. The break-off in the spectra correlates with the calculated barriers toward the “C5-C6 twist” conical intersection, which unambiguously establishes the decay mechanism at low S1 state vibrational energies. The barriers increase with substituents that stabilize the charge shifts at C4, C5, and C6 following (1ππ*) excitation. The R2PI spectra of the clamped derivatives 5,6-trimethyleneCyt (TMCyt) and 1-methyl-TMCyt (1M-TMCyt), which decay along an N3 out-of-plane coordinate, extend up to +3500 and +4500 cm-1.
Locating Cytosine Conical Intersections by Laser Experiments and Ab Initio Calculations.
Trachsel MA1, Blaser S1, Lobsiger S1, Siffert L1, Frey HM1, Blancafort L2, Leutwyler S1.
2020 Apr 10