Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
494.5±40.0 °C at 760 mmHg
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provides coniferyl ferulate(CAS#:488-82-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Urinary chemical fingerprint left behind by repeated NSAID administration: Discovery of putative biomarkers using artificial intelligence
Liam E Broughton-Neiswanger 1, Sol M Rivera-Velez 1, Martin A Suarez 2, Jennifer E Slovak 3, Pablo E PiNeyro 4, Julianne K Hwang 1, Nicolas F Villarino 1
2020 Feb 13;
Ribose 5-phosphate isomerase deficiency is a rare genetic leukoencephalopathy caused by pathogenic sequence variants in RPIA, that encodes ribose 5-phosphate isomerase, an enzyme in the pentose phosphate pathway. Till date, only three individuals with ribose 5-phosphate isomerase deficiency have been described in literature. We report on a subject with RPIA associated progressive leukoencephalopathy with elevated urine arabitol and ribitol levels and a novel missense variant c.770T > C p.(Ile257Thr) in exon 8 of RPIA. We also compare the phenotypes of all the four subjects. Our report confirms the phenotype and the genetic cause of this condition.
Epilepsy; Leukoencephalopathy; Pentose phosphate pathway; RPIA; Ribose 5-phosphate isomerase deficiency.
Confirmation of a Rare Genetic Leukoencephalopathy due to a Novel Bi-allelic Variant in RPIA
Parneet Kaur 1, Mirjam M C Wamelink 2, Marjo S van der Knaap 3, Katta Mohan Girisha 1, Anju Shukla 4
Specialised metabolites in lichens are generally considered repellent compounds by consumers. Nevertheless, if the only food available is lichens rich in specialised metabolites, lichenophages must implement strategies to overcome the toxicity of these metabolites. Thus, the balance between phagostimulant nutrients and deterrent metabolites could play a key role in feeding preferences. To further understand lichen-gastropod interactions, we studied the feeding behaviour and consumption in Notodiscus hookeri, the land snail native to sub-Antarctic islands. The lichen Usnea taylorii was used because of its simple chemistry, its richness in usnic acid (specialised metabolite) and arabitol (primary metabolite) and its presence in snail habitats. Choice tests in arenas with intact lichens versus acetone-rinsed lichens were carried out to study the influence of specialised metabolites on snail behaviour and feeding preference. Simultaneously, usnic acid and arabitol were quantified and located within the lichen thallus using HPLC-DAD-MS and in situ imaging by mass spectrometry to assess whether their spatial distribution explained preferential snail grazing. No-choice feeding experiments, with the pure metabolites embedded in an artificial diet, defined a gradual gustatory response, from strong repellence (usnic acid) to high appetence (D-arabitol). This case study demonstrates that the nutritional activity of N. hookeri is governed by the chemical quality of the food and primarily by nutrient availability (arabitol), despite the presence of deterrent metabolite (usnic acid).
D-arabitol; Feeding choice; Lichen; Mass spectrometry imaging; Notodiscus hookeri; Parmeliaceae; Snail; Usnea taylorii; Usnic acid.
Alice Gadea 1, Maryvonne Charrier 2, Mathieu Fanuel 3, Philippe Clerc 4, Corentin Daugan 5, Aurelie Sauvager 5, Helene Rogniaux 3, Joël Boustie 5, Anne-Cecile Le Lamer 6, Francoise Lohezic-Le Devehat 7