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D-Mannitol

$43

  • Brand : BIOFRON

  • Catalogue Number : BF-D2011

  • Specification : 98%

  • CAS number : 69-65-8

  • Formula : C6H14O6

  • Molecular Weight : 182.17

  • Volume : 20mg

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Catalogue Number

BF-D2011

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

182.17

Appearance

White crystalline powder

Botanical Source

Canarium album

Structure Type

Carbohydrates

Category

SMILES

C(C(C(C(C(CO)O)O)O)O)O

Synonyms

IUPAC Name

Density

1.6±0.1 g/cm3

Solubility

H2O : ≥ 36 mg/mL (197.62 mM)
*"≥" means soluble, but saturation unknown.

Flash Point

292.5±23.3 °C

Boiling Point

494.9±0.0 °C at 760 mmHg

Melting Point

167-170ºC

InChl

InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2

InChl Key

FBPFZTCFMRRESA-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2905430000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:69-65-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

32418958

Abstract

Cold ischemic injury in heart storage is an important issue pertaining to heart transplantation. This study aims to evaluate the addition of compound glycyrrhizin (CG) in histidine-tryptophan-ketoglutarate (HTK) solution on chronic isograft injury in comparison to traditional HTK solution.Hearts of mouse were stored for 8 h in 4°C cold preservation solution and then transplanted heterotopically into mouse. Five groups were evaluated: HTK, low dose of CG solution (LCG), medium dose of CG solution (MCG), high dose of CG solution (HCG), and hearts without cold ischemia (sham). Survival was assessed. Time to restoration of heartbeat and strength of the heartbeat was measured. Lactate dehydrogenase (LDH) and creatine kinase (CK) levels in the preservation solution were determined. The myocardial damage and interstitial fibrosis of transplanted hearts were evaluated. TGF-β1 expression in the transplanted hearts was assessed.Addition of CG to HTK solution significantly attenuated cold ischemic injury during cold storage, as evidenced by the lower time to restoration of heartbeat, higher strength of the heartbeat, lower LDH, and CK leakage. After transplantation, hearts stored in HTK solution containing CG had decreased the myocardial damage and interstitial fibrosis, compared with those stored without CG. The percentage of TGF-β1-positive cells and TGF-β1 level in the transplanted hearts were also decreased when stored in CG-containing HTK solution.The addition of CG to HTK solution attenuates cold ischemic injury during cold storage.

KEYWORDS

Chronic isograft injury; Heart storage; Myocardial protection.

Title

Reduction of Cold Ischemic Injury With the Addition of Compound Glycyrrhizin in HTK Solution in a Mouse Heart Transplantation Model

Author

Jiali Wu 1, Xiangdong Liu 2, Maohua Wang 1, Xiaobin Wang 1, De Luo 2, Song Su 2

Publish date

2020 May 30

PMID

32248158

Abstract

Objective: The aim: Investigate the effect of 0.9% NaCl, HES 130, HAES-LX-5% and mannitol 15% on cerebral hemodynamics in patients with AIS.

Patients and methods: Materials and methods: The study included 100 patients with AIS. As the investigated solutions were used: isosmolar 0.9% NaCl, hyperosmolar mannitol 15%, colloid-isoosmolar HES 130, colloid-hyperosmolar HAES-LX-5%. The control group received only 0.9% NaCl compared: 0.9% NaCl+HES 130, 0.9% NaCl+HAES-LX-5%, 0.9% NaCl+mannitol 15%. Evaluation of cerebral hemodynamic (indexes of cerebral blood flow) was performed using doppler ultrasound of cerebral arteries.

Results: Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%. In patients with HES 130 solution cerebral blood flow increases by 14.2%, whereas when applied HAES-LX-5% during 7 days, it increases by 43.2% (p=0.004).

Conclusion: Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.

KEYWORDS

0.9% NaCl; HES 130; acute ischemic stroke; HAES-LX-5%; mannitol; infusion therapy.

Title

Influence of Different Qualitative Composition of Infusion Solutions on Cerebral Hemodynamics in Patients With Acute Ischemic Stroke

Author

Andrii I Semenenko 1, Halyna I Khrebtii 2, Svetlana L Malyk 3, Dmytro V Dmytriiev 1, Roksolana Ya Bodnar 4, Lesia M Zheliba 1, Yuliia V Lomakina 2, Mohammad Wathek O Alsalama 2

Publish date

2020

PMID

32115532

Abstract

A concise spherical granulation method is required to prepare extemporaneously granules remanufactured from oral dosage forms for administration to individuals who cannot swallow tablets or capsules. In this study, we determined the feasibility of spherical granulation using a planetary centrifugal mixer. A model formulation, 20% ibuprofen (IBP) granules, was prepared using a lactose/cornstarch (7 : 3, w/w) mixture or D-mannitol as diluents, and changes in granule characteristics (mean diameter (d50), distribution range of granule size (span), and yield) were evaluated according to the amount of water added and the granulation time. The amount of water was assessed using the plastic limit value as measured using a digital force gauge. We successfully produced granules, and larger amounts of water and longer granulation times resulted in larger d50 values and smaller span values. The optimal granulation time was 45 s and the optimal water contents were 70 and 67.5% of the plastic limit value for the lactose/cornstarch mixture and D-mannitol, respectively. When compared to commercial 20% IBP granules, powder X-ray diffraction and differential scanning calorimetry analyses showed that the granulation process did not alter the crystallinity of the drug. Thus, this novel granulation method using a planetary centrifugal mixer may be a promising technique for compounding in pharmacies and in pharmaceutical manufacturing.

KEYWORDS

extemporaneous preparation; penetration resistance force; planetary centrifugal mixer; plastic limit value; spherical granulation.

Title

Small-Scale Spherical Granulation Using a Planetary Centrifugal Mixer

Author

Takashi Eda 1, Yasunori Miyazaki 1, Tomonobu Uchino 1, Yoshiyuki Kagawa 1

Publish date

2020


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