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Decanedioic acid

$96

  • Brand : BIOFRON

  • Catalogue Number : BN-O1599

  • Specification : 98%(HPLC)

  • CAS number : 111-20-6

  • Formula : C10H18O4

  • Molecular Weight : 202.3

  • PUBCHEM ID : 5192

  • Volume : 100mg

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Catalogue Number

BN-O1599

Analysis Method

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

202.3

Appearance

Powder

Botanical Source

This product is isolated and purified from the herbs of Piper cubeba.

Structure Type

Category

SMILES

C(CCCCC(=O)O)CCCC(=O)O

Synonyms

1,10-decanedioic acid/octane-1,8-dicarboxylic acid/decane-1,10-dioic acid/sebacinsaure/Sebacic acid/Sebacinsure/Decanedioic acid/Decanedioic/1,8-Octanedicarboxylic Acid/Seracic acid

IUPAC Name

Density

1.1±0.1 g/cm3

Solubility

Flash Point

198.3±19.7 °C

Boiling Point

374.3±0.0 °C at 760 mmHg

Melting Point

133-137 °C(lit.)

InChl

InChl Key

CXMXRPHRNRROMY-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:111-20-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

29191404

Abstract

The modeling and simulation software COMSOL Multiphysics® was recently extended with an electrophoretic transport interface. Its performance was investigated by comparison to results obtained using the 1D dynamic electrophoresis simulators GENTRANS and SIMUL5. Simulations of zone electrophoresis, isotachophoresis, isoelectric focusing and of an oscillating electrolyte system were performed. Smooth profiles were essentially identical indicating that the COMSOL electrophoretic transport interface is able to reproduce results of the 1D simulators. Differences in the way the respective numerical schemes handle steep concentration gradients and associated instabilities were observed. The COMSOL electrophoretic transport interface is expected to be useful as a general model for simulations in 1D, 2D or 3D geometries, as well as for simulations combining electrophoresis with other physical phenomena.

KEYWORDS

COMSOL multiphysics; Computer simulation; Electrophoresis; Isoelectric focusing; Isotachophoresis; Zone electrophoresis.

Title

High-resolution Dynamic Computer Simulation of Electrophoresis Using a Multiphysics Software Platform

Publish date

2018 Jan 12

PMID

27198864

Abstract

We report on a synthetic method where polyanhydride is used as starting material and the ester monomers are inserted through complete esterification, leading to an alternating ester-anhydride copolymer. The molar ratio of ricinoleic acid (RA) and sebacic acid (SA) was optimized until polysebacic acid is completely converted to carboxylic acid-terminated RA-SA and RA-SA-RA ester-dicarboxylic acids. These dimers and trimers were activated with acetic anhydride, polymerized under heat and vacuum to yield alternating RA-SA copolymer. The resulting alternating poly(ester-anhydride) have the RA at regular intervals. The regular occurrences of RA side chains prevent anhydride interchange, enhancing hydrolytic stability, which allows storage of the polymer at room temperature.

Title

Alternating Poly(ester-anhydride) by Insertion Polycondensation

Author

Moran Haim-Zada 1, Arijit Basu 1, Tal Hagigit 2, Ron Schlinger 2, Michael Grishko 3, Alexander Kraminsky 3, Ezra Hanuka 3, Abraham J Domb 1

Publish date

2016 Jun 13

PMID

29617113

Abstract

The development of high-throughput techniques and combinatorial libraries can facilitate rapid synthesis and screening of biomaterial-based nanocarriers for drug and vaccine delivery. This study describes a high-throughput method using an automated robot for synthesizing polyanhydride nanoparticles encapsulating proteins. Polyanhydrides are a class of safe and biodegradable polymers that have been widely used as drug and vaccine delivery vehicles. The robot contains a multiplexed homogenizer and has the capacity to handle parallel streams of monomer or polymer solutions to synthesize polymers and/or nanoparticles. Copolymer libraries were synthesized using the monomers sebacic acid, 1,6-bis( p-carboxyphenoxy)hexane, and 1,8-bis( p-carboxyphenoxy)-3,6-dioxactane and compared to conventionally synthesized copolymers. Nanoparticle libraries of varying copolymer compositions encapsulating the model antigen ovalbumin were synthesized using flash nanoprecipitation. The amount of the surfactant Span 80 was varied to test its effect on protein encapsulation efficiency as well as antigen release kinetics. It was observed that, although the amount of surfactant did not significantly affect protein release rate, its presence enhanced protein encapsulation efficiency. Protein burst and release kinetics from conventionally and combinatorially synthesized nanoparticles were similar even though particles synthesized using the high-throughput technique were smaller. Finally, it was demonstrated that the high-throughput method could be adapted to functionalize the surface of particle libraries to aid in the design and screening of targeted drug and vaccine delivery systems. These results suggest that the new high-throughput method is a viable alternative to conventional methods for synthesizing and screening protein and vaccine delivery vehicles.

KEYWORDS

high-throughput synthesis; nanoparticles; polyanhydride; protein delivery; surface functionalization.

Title

Automated High-Throughput Synthesis of Protein-Loaded Polyanhydride Nanoparticle Libraries

Author

Jonathan T Goodman 1, Adam S Mullis 1, Lucas Dunshee 1, Akash Mitra 1, Balaji Narasimhan 1

Publish date

2018 May 14;


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