14H-Benzo[a]-1,3-benzodioxolo[4,5-g]quinolizine, 6,6a-dihydro-8,9-dimethoxy-6-methyl-, (6S,6aR)-/Benzo(a)-1,3-benzodioxolo(4,5-g)quinolizinium,8,9-dimethoxy-6-methyl/(6S,6aR)-8,9-Dimethoxy-6-methyl-6,14-dihydro-6aH-[1,3]dioxolo[4,5-h]isoquinolino[2,1-b]isoquinoline/Dehydrocavidine
Dehydrocavidine, a main active ingredient of Corydalis saxicola Bunting (Yanhuanglian), displays antinociceptive, hepatoprotective, and spasmolytic activities. Dehydrocavidine kills hepatitis viruses and promotes regeneration of hepatocytes.
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
506.0±50.0 °C at 760 mmHg
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For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:83218-34-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Tonga was highly endemic for lymphatic filariasis (LF) caused by diurnally sub-periodic Wuchereria bancrofti transmitted by Aedes vector species. LF prevalence declined very appreciably as a result of chemotherapeutic intervention measures implemented in 1977, but low levels of infection persisted. Along with other Pacific Island countries and in partnership with the Pacific Programme to Eliminate LF (PacELF), Tonga implemented a programme to eliminate LF as a public health problem.
On the basis of historical data and baseline survey, all the divisions of the country were declared as endemic. Five to six consecutive rounds of effective MDA were implemented in all the divisions during 2001-2006. The impact of MDA was assessed through interim and post-MDA antigen (Ag) detection surveys among adults and transmission assessment surveys among children. The chronic disease burden was assessed by health workers through observation.
The base-line Ag prevalence was 2.70%. The treatment coverage was > 80% in all MDA rounds. The mid-term surveys showed an Ag prevalence of 2.46%. The pre-stop MDA Ag survey revealed an Ag prevalence of 0.34%. The stop MDA survey and transmission assessment surveys among children showed Ag prevalence at < 0.05%, indicating transmission is negligible. Health workers concluded that filarial lymphedema or hydrocele condition in the communities is absent or very rare. Conclusion Tonga had successfully met the criteria for elimination of LF as a public health problem. The accomplishment was acknowledged by the WHO in 2017. Tonga looks forward to work with stakeholders to eliminate transmission of LF and achieve zero incidence of infection.
Lymphatic filariasis, Wuchereria bancrofti, Elimination, PacELF, Tonga
Elimination of lymphatic filariasis as a public health problem from Tonga
Reynold `Ofanoa,1 Tukia Ofa,1 E. A. Padmasiri,2 and D. Ramaiah Kapacorresponding author3
Focal adhesions (FA) are a complex network of proteins that allow the cell to form physical contacts with the extracellular matrix (ECM). FA assemble and disassemble in a dynamic process, orchestrated by a variety of cellular components. However, the underlying mechanisms that regulate adhesion turnover remain poorly understood. Here we show that RhoG, a Rho GTPase related to Rac, modulates FA dynamics. When RhoG expression is silenced, FA are more stable and live longer, resulting in an increase in the number and size of adhesions, which are also more mature and fibrillar-like. Silencing RhoG also increases the number and thickness of stress fibers, which are sensitive to blebbistatin, suggesting contractility is increased. The molecular mechanism by which RhoG regulates adhesion turnover is yet to be characterized, but our results demonstrate that RhoG plays a role in the regulation of microtubule-mediated FA disassembly.
The small GTPase RhoG regulates microtubule-mediated focal adhesion disassembly
Ashtyn Zinn,1 Silvia M. Goicoechea,1 Gabriel Kreider-Letterman,1 Debonil Maity,2 Sahezeel Awadia,1 Luis Cedeno-Rosario,1 Yun Chen,2 and Rafael Garcia-Matacorresponding author1
The lattice of 5,7,12,14-tetrahydro-5,14:7,12-bis([1,2]benzeno)pentacene-6,13-dione, C34H20O2, at 173?K has triclinic (P-1) symmetry and crystallizes with four independent half-molecules in the asymmetric unit. Each molecule is generated from a C17H10O substructure through an inversion center at the centroid of the central quinone ring, generating a wide H-shaped molecule, with a dihedral angle between the mean planes of the terminal benzene rings in each of the two symmetry-related pairs over the four molecules of 68.6?(1) (A), 65.5?(4) (B), 62.3?(9) (C), and 65.8?(8)° (D), an average of 65.6?(1)°. This compound has applications in gas-separation membranes constructed from polymers of intrinsic microporosity (PIM). The title compound is a product of a double Diels-Alder reaction between anthracene and p-benzoquinone followed by dehydrogenation. It has also been characterized by cyclic voltammetry and rotating disc electrode polarography, FT-IR, high resolution mass spectrometry, elemental analysis, and 1H NMR.
crystal structure, iptycene, pentiptycene, polymers of intrinsic microporosity (PIM), quinone, voltammetry
Crystal structure of 5,7,12,14-tetrahydro-5,14:7,12-bis([1,2]benzeno)pentacene-6,13-dione1
Mohammad Nozari,a,* Jerry P. Jasinski,b Manpreet Kaur,b Anthony W. Addison,a Ahmad Arabi Shamsabadi,c and Masoud Soroushc
2016 Dec 1;