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Dehydrocorydaline

$640

  • Brand : BIOFRON

  • Catalogue Number : BD-D1082

  • Specification : HPLC≥98%

  • CAS number : 83218-34-2

  • Formula : C21H18NO4

  • Molecular Weight : 348.37

  • PUBCHEM ID : 158329

  • Volume : 20mg

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Catalogue Number

BD-D1082

Analysis Method

HPLC,NMR,MS

Specification

HPLC≥98%

Storage

2-8°C

Molecular Weight

348.37

Appearance

Powder

Botanical Source

Structure Type

Alkaloids

Category

Standards;Natural Pytochemical;API

SMILES

CC1C2C3=CC(=C(C=C3C=CN2CC4=C1C=CC5=C4OCO5)OC)OC

Synonyms

14H-Benzo[a]-1,3-benzodioxolo[4,5-g]quinolizine, 6,6a-dihydro-8,9-dimethoxy-6-methyl-, (6S,6aR)-/Benzo(a)-1,3-benzodioxolo(4,5-g)quinolizinium,8,9-dimethoxy-6-methyl/(6S,6aR)-8,9-Dimethoxy-6-methyl-6,14-dihydro-6aH-[1,3]dioxolo[4,5-h]isoquinolino[2,1-b]isoquinoline/Dehydrocavidine

IUPAC Name

16,17-dimethoxy-12-methyl-5,7-dioxa-1-azoniapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),9,11,14,16,18,20-nonaene

Applications

Dehydrocavidine, a main active ingredient of Corydalis saxicola Bunting (Yanhuanglian), displays antinociceptive, hepatoprotective, and spasmolytic activities. Dehydrocavidine kills hepatitis viruses and promotes regeneration of hepatocytes[1].

Density

1.3±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

149.9±27.3 °C

Boiling Point

506.0±50.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C21H21NO4/c1-12-14-4-5-17-21(26-11-25-17)16(14)10-22-7-6-13-8-18(23-2)19(24-3)9-15(13)20(12)22/h4-9,12,20H,10-11H2,1-3H3/t12-,20+/m0/s1

InChl Key

XSOKSDXTNIQQJD-FKIZINRSSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:83218-34-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

31346312

Abstract

Background
Tonga was highly endemic for lymphatic filariasis (LF) caused by diurnally sub-periodic Wuchereria bancrofti transmitted by Aedes vector species. LF prevalence declined very appreciably as a result of chemotherapeutic intervention measures implemented in 1977, but low levels of infection persisted. Along with other Pacific Island countries and in partnership with the Pacific Programme to Eliminate LF (PacELF), Tonga implemented a programme to eliminate LF as a public health problem.

Methods
On the basis of historical data and baseline survey, all the divisions of the country were declared as endemic. Five to six consecutive rounds of effective MDA were implemented in all the divisions during 2001-2006. The impact of MDA was assessed through interim and post-MDA antigen (Ag) detection surveys among adults and transmission assessment surveys among children. The chronic disease burden was assessed by health workers through observation.

Results
The base-line Ag prevalence was 2.70%. The treatment coverage was > 80% in all MDA rounds. The mid-term surveys showed an Ag prevalence of 2.46%. The pre-stop MDA Ag survey revealed an Ag prevalence of 0.34%. The stop MDA survey and transmission assessment surveys among children showed Ag prevalence at < 0.05%, indicating transmission is negligible. Health workers concluded that filarial lymphedema or hydrocele condition in the communities is absent or very rare.

Conclusion
Tonga had successfully met the criteria for elimination of LF as a public health problem. The accomplishment was acknowledged by the WHO in 2017. Tonga looks forward to work with stakeholders to eliminate transmission of LF and achieve zero incidence of infection.

KEYWORDS

Lymphatic filariasis, Wuchereria bancrofti, Elimination, PacELF, Tonga

Title

Elimination of lymphatic filariasis as a public health problem from Tonga

Author

Reynold `Ofanoa,1 Tukia Ofa,1 E. A. Padmasiri,2 and D. Ramaiah Kapacorresponding author3

Publish date

2019;

PMID

30914742

Abstract

Focal adhesions (FA) are a complex network of proteins that allow the cell to form physical contacts with the extracellular matrix (ECM). FA assemble and disassemble in a dynamic process, orchestrated by a variety of cellular components. However, the underlying mechanisms that regulate adhesion turnover remain poorly understood. Here we show that RhoG, a Rho GTPase related to Rac, modulates FA dynamics. When RhoG expression is silenced, FA are more stable and live longer, resulting in an increase in the number and size of adhesions, which are also more mature and fibrillar-like. Silencing RhoG also increases the number and thickness of stress fibers, which are sensitive to blebbistatin, suggesting contractility is increased. The molecular mechanism by which RhoG regulates adhesion turnover is yet to be characterized, but our results demonstrate that RhoG plays a role in the regulation of microtubule-mediated FA disassembly.

Title

The small GTPase RhoG regulates microtubule-mediated focal adhesion disassembly

Author

Ashtyn Zinn,1 Silvia M. Goicoechea,1 Gabriel Kreider-Letterman,1 Debonil Maity,2 Sahezeel Awadia,1 Luis Cedeno-Rosario,1 Yun Chen,2 and Rafael Garcia-Matacorresponding author1

Publish date

2019;

PMID

27980819

Abstract

The lattice of 5,7,12,14-tetra­hydro-5,14:7,12-bis­([1,2]benzeno)­penta­cene-6,13-dione, C34H20O2, at 173 K has triclinic (P-1) symmetry and crystallizes with four independent half-mol­ecules in the asymmetric unit. Each mol­ecule is generated from a C17H10O substructure through an inversion center at the centroid of the central quinone ring, generating a wide H-shaped mol­ecule, with a dihedral angle between the mean planes of the terminal benzene rings in each of the two symmetry-related pairs over the four mol­ecules of 68.6 (1) (A), 65.5 (4) (B), 62.3 (9) (C), and 65.8 (8)° (D), an average of 65.6 (1)°. This compound has applications in gas-separation membranes constructed from polymers of intrinsic microporosity (PIM). The title compound is a product of a double Diels-Alder reaction between anthracene and p-benzo­quinone followed by de­hydrogenation. It has also been characterized by cyclic voltammetry and rotating disc electrode polarography, FT-IR, high resolution mass spectrometry, elemental analysis, and 1H NMR.

KEYWORDS

crystal structure, iptycene, pentiptycene, polymers of intrinsic microporosity (PIM), quinone, voltammetry

Title

Crystal structure of 5,7,12,14-tetra­hydro-5,14:7,12-bis­([1,2]benzeno)­penta­cene-6,13-dione1

Author

Mohammad Nozari,a,* Jerry P. Jasinski,b Manpreet Kaur,b Anthony W. Addison,a Ahmad Arabi Shamsabadi,c and Masoud Soroushc

Publish date

2016 Dec 1;