3β-hydroxylanosta-7,9(11)24-trien-21-oic acid/3-epidehydrotrametenolic/3-epi-dehydrotrametenolic acid/3β-hydroxylanosta-7,9(11),24-trien-21-oic acid/3-epidehydrotrametenolic acid/(3β)-3-Hydroxylanosta-7,9(11),24-trien-21-oic acid/Lanosta-7,9(11),24-trien-21-oic acid, 3-hydroxy-, (3β)-/3beta-Hydroxylanosta-7,9(11),24-trien-21-oic acid
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provides coniferyl ferulate(CAS#:29220-16-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
We recently discovered that the triterpene acid compound dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. This natural product has been isolated from dried sclerotia of Poria cocos WOLF (Polyporaceae), a well-known traditional Chinese medicinal plant. We examined the effects of dehydrotrametenolic acid on plasma glucose concentration in obese hyperglycemic db/db mice. Dehydrotrametenolic acid can reduce hyperglycemia in mouse models of noninsulin-dependent diabetes mellitus (NIDDM) and act as an insulin sensitizer as indicated by the results of the glucose tolerance test. These terpenoids and thiazolidine type of antidiabetic agents such as Ciglitazone, although structurally unrelated, share many biological activities: both induce adipose conversion, activate peroxisome proliferator-activated receptor gamma (PPAR gamma) in vitro, and reduce hyperglycemia in animal models of NIDDM. Dehydrotrametenolic acid is a promising candidate for a new type of insulin-sensitizing drug. This finding is very important for the development of insulin sensitizers that are not of the thiazolidine type.
Dehydrotrametenolic Acid Induces Preadipocyte Differentiation and Sensitizes Animal Models of Noninsulin-Dependent Diabetes Mellitus to InsulinQ
Mayumi Sato 1 , Takaaki Tai, Yoshiki Nunoura, Yukiko Yajima, Seiichi Kawashima, Keiji Tanaka
The screening of natural products that preferentially inhibit growth of H-ras transformed rat2 cells vs. rat2 cells was performed to identify H-ras specific growth inhibitor. A lanostane-type triterpene acid, dehydrotrametenolic acid (3beta-hydroxylanosta-7,9(11),24-trien-21-oic acid), was isolated from the sclerotium of Poria cocos (Polyporaceae). Dehydrotrametenolic acid selectively inhibited the growth of H-ras transformed cells with a GI(50) value of 40 microM. FACS analysis indicated that the compound exerted its anti-proliferation effects through cell cycle arrest at G2/M phase and accumulation of sub-G1 population. Dehydrotrametenolic acid-induced apoptosis was further confirmed with chromosomal DNA fragmentation, caspase-3 activation, and degradation of PARP and Lamin A/C degradation. The compound also regulated the expression of H-ras, Akt and Erk, which are the downstream proteins of H-ras signaling pathways. The results suggest that dehydrotrametenolic acid can be a potential anticancer agent against H-ras transformed tumor. Q
Dehydrotrametenolic Acid Selectively Inhibits the Growth of H-ras Transformed rat2 Cells and Induces Apoptosis Through caspase-3 Pathway
Hyun-Mi Kang 1 , Su-Kyung Lee, Dae-Seop Shin, Mi-Young Lee, Dong Cho Han, Nam-In Baek, Kwang-Hee Son, Byoung-Mog Kwon
2006 Jan 2
Dehydrotrametenolic acid (DTA) is a lanostane-type triterpene acid isolated from Poria cocos Wolf (Polyporaceae). Several studies have reported the anti-inflammatory and antidiabetic effects of DTA; however, its effects on the skin are poorly understood. In this study, we investigated the effects of DTA on skin barrier function in vitro and its regulatory mechanism in human keratinocyte cell line HaCaT cells. DTA increased the microRNA (mRNA) expression of natural moisturizing factor-related genes, such as HAS-2, HAS-3, and AQP3 in HaCaT cells. DTA also upregulated the mRNA expression of various keratinocyte differentiation markers, including TGM-1, involucrin, and caspase-14. Moreover, the protein expression of HAS-2, HAS-3, and TGM-2 were significantly increased by DTA. To examine the regulatory mechanisms of DTA, Western blotting, luciferase-reporter assays, and RT-PCR were conducted. The phosphorylation of mitogen-activated protein kinases (MAPKs) and IκBα were increased in DTA-treated HaCaT cells. In addition, AP-1 and NF-κB transcriptional factors were dose-dependently activated by DTA. Taken together, our in vitro mechanism studies indicate that the regulatory effects of DTA on skin hydration and keratinocyte differentiation are mediated by the MAPK/AP-1 and IκBα/NF-κB pathways. In addition, DTA could be a promising ingredient in cosmetics for moisturizing and increased skin barrier function.
keratinocyte differentiation; skin barrier; skin hydration.
In Vitro Effects of Dehydrotrametenolic Acid on Skin Barrier Function
Eunju Choi 1 , Young-Gyu Kang 2 , So-Hyeon Hwang 1 , Jin Kyeong Kim 1 , Yong Deog Hong 2 , Won-Seok Park 2 , Donghyun Kim 2 , Eunji Kim 1 , Jae Youl Cho 1
2019 Dec 14