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Demecolcine

$52

  • Brand : BIOFRON

  • Catalogue Number : BN-O1821

  • Specification : 98%(HPLC)

  • CAS number : 477-30-5

  • Formula : C21H25NO5

  • Molecular Weight : 371.4

  • PUBCHEM ID : 220401

  • Volume : 20mg

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Catalogue Number

BN-O1821

Analysis Method

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

371.4

Appearance

Botanical Source

Structure Type

Category

SMILES

CNC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC

Synonyms

Benzo[a]heptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (7S)-/Benzo[a]heptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (S)-/Demecolcine/Benzo(a)heptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (S)-/(7S)-1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one/demecolcinum/Colcemid/demecolcina/N-Deacetyl-N-methylcolchicine

IUPAC Name

(7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one

Applications

Density

1.2±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

332.1±31.5 °C

Boiling Point

625.5±55.0 °C at 760 mmHg

Melting Point

73-75ºC

InChl

InChl Key

NNJPGOLRFBJNIW-HNNXBMFYSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:477-30-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

7720099

Abstract

Demecolcine (Colcemid), an inhibitor of spindle fiber formation in M phase, induced apoptosis in V79 cells. At a concentration of 0.01 microgram/ml demecolcine, V79 cells proliferated exponentially as well as controls, although temporal M phase accumulation occurred 6 h after the addition of demecolcine. At 0.1 microgram/ml, the cells became hyperploid after remaining in the M phase for some time. Apoptosis occurred in V79 cells exposed to demecolcine at a concentration of 0.03 microgram/ml. Apoptosis was defined as the appearance of a sub-G1 peak in DNA histograms and a ladder pattern of fragmented DNA in gelelectrophoresis.

Title

Apoptosis by demecolcine in V79 cells.

Author

Fujikawa-Yamamoto K1, Teraoka K, Zong ZP, Yamagishi H, Odashima S.

Publish date

1994 Dec