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Demethylbellidifolin

$672

  • Brand : BIOFRON

  • Catalogue Number : BD-P0977

  • Specification : 98.0%(HPLC)

  • CAS number : 2980-32-7

  • Formula : C13H8O6

  • Molecular Weight : 260.2

  • PUBCHEM ID : 5281626

  • Volume : 25mg

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Catalogue Number

BD-P0977

Analysis Method

HPLC,NMR,MS

Specification

98.0%(HPLC)

Storage

2-8°C

Molecular Weight

260.2

Appearance

Yellow crystalline powder

Botanical Source

Gentiana bellidifolia and of Swertia spp.

Structure Type

Category

Standards;Natural Pytochemical;API

SMILES

C1=CC(=C2C(=C1O)C(=O)C3=C(C=C(C=C3O2)O)O)O

Synonyms

Demethylbellidifolin/Xanthen-9-one,1,3,5,8-tetrahydroxy/Desmethylbellidifolin/Bellidin/norbellidifolin/1,3,5,8-tetrahydroxyxanthone/Desmethybellidifolin/norbellidifodin/1,3,5,8-Tetrahydroxy-9H-xanthen-9-one/9H-Xanthen-9-one, 1,3,5,8-tetrahydroxy-/1,3,5,8-tetrahydroxy-xanthen-9-one/1,3,5,8-tetrahydroxyxanthen-9-one

IUPAC Name

1,3,5,8-tetrahydroxyxanthen-9-one

Applications

Density

1.8±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

242.0±25.0 °C

Boiling Point

605.6±55.0 °C at 760 mmHg

Melting Point

317ºC

InChl

InChI=1S/C13H8O6/c14-5-3-8(17)10-9(4-5)19-13-7(16)2-1-6(15)11(13)12(10)18/h1-4,14-17H

InChl Key

MPXAWSABMVLIBU-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2933990000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:2980-32-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

29997352

Abstract

This study used the 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide radical (PTIO•) trapping model to study the antioxidant activities of 16 natural xanthones in aqueous solution, including garcinone C, γ-mangostin, subelliptenone G, mangiferin, 1,6,7-trihydroxy-xanthone, 1,2,5-trihydroxyxanthone, 1,5,6-trihydroxyxanthone, norathyriol, 1,3,5,6-tetrahydroxy-xanthone, isojacareubin, 1,3,5,8-tetrahydroxyxanthone, isomangiferin, 2-hydroxyxanthone, 7-O-methylmangiferin, neomangiferin, and lancerin. It was observed that most of the 16 xanthones could scavenge the PTIO• radical in a dose-dependent manner at pH 4.5 and 7.4. Among them, 12 xanthones of the para-di-OHs (or ortho-di-OHs) type always exhibited lower half maximal inhibitory concentration (IC50) values than those not of the para-di-OHs (or ortho-di-OHs) type. Ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UPLC-ESI-Q-TOF-MS/MS) analysis revealed that most of these xanthones gave xanthone-xanthone dimers after incubation with PTIO•, except for neomangiferin. Based on these data, we concluded that the antioxidant activity of phenolic xanthone may be mediated by electron-transfer (ET) plus H+-transfer mechanisms. Through these mechanisms, some xanthones can further dimerize unless they bear huge substituents with steric hindrance. Four substituent types (i.e., para-di-OHs, 5,6-di-OHs, 6,7-di-OHs, and 7,8-di-OHs) dominate the antioxidant activity of phenolic xanthones, while other substituents (including isoprenyl and 3-hydroxy-3-methylbutyl substituents) play a minor role as long as they do not break the above four types.

KEYWORDS

xanthone, structure-activity relationship, antioxidant, ortho-di-OHs, para-di-OHs

Title

2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide Radical (PTIO•) Trapping Activity and Mechanisms of 16 Phenolic Xanthones

Author

Xican Li,1,2,*† Ban Chen,1,2,† Xiaojun Zhao,1,2 and Dongfeng Chen3,4,*

Publish date

2018 Jul;

PMID

30258745

Abstract

The structure-activity relationships of 31 xanthones were analyzed by using the ferric reducing antioxidant power (FRAP) assay to determine their electron‐transfer (ET) potential. It was proven that the ET potential of xanthones was dominated by four moieties (i.e. hydroquinone moiety, 5,6‐catechol moiety, 6,7‐catechol moiety, and 7,8‐catechol moiety) and was only slightly affected by other structural features, including a single phenolic OH group, the resorcinol moiety, the transannular dihydroxy moiety, a methoxy group, a sugar residue, an isoprenyl group, a cyclized isoprenyl group, and an isopentanol group. The results could be used to predict the ET potentials of other antioxidant xanthones.

KEYWORDS

antioxidants, electron transfer, fused-ring systems, structure-activity relationships, xanthones

Title

Structure-Activity Relationship and Prediction of the Electron‐Transfer Potential of the Xanthones Series

Author

Prof. Xican Li,corresponding author 1 , 2 Qian Jiang, 1 , 2 Ban Chen, 1 , 2 Xiaoling Luo, 1 and Prof. Dongfeng Chencorresponding author 3 , 4

Publish date

2018 Sep;