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Demethylpodophyllotoxin, 4′-

$45

  • Brand : BIOFRON

  • Catalogue Number : AV-P10232

  • Specification : 98%

  • CAS number : 6559-91-7

  • Formula : C21H20O8

  • Molecular Weight : 400.38

  • PUBCHEM ID : 122797

  • Volume : 25mg

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Catalogue Number

AV-P10232

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

400.38

Appearance

White crystalline powder

Botanical Source

Sinopodophyllum hexandrum (Royle) Ying; Dysosma versipellis (Hance) M. Cheng ex Ying

Structure Type

Lignanoids

Category

Standards;Natural Pytochemical;API

SMILES

COC1=CC(=CC(=C1O)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O

Synonyms

(5R,5aR,8aR,9S)-9-Hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one/4'-DMEP/4'-Demethylepipodophyllotoxin/4-DEMETHYL EIPODOPHYLLOTOXIN/4-Domethylpodophyllotoxin,4'-demethyl-epi-Podophyllotoxin/Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9S)-/4'-demethyl-9-epipodophyllotoxin/4'-demethyl-epipodophyllotoxin/4'-demethyl-4-epipodophyllotoxin/4'-O-demethyl-4-epipodophyllotoxin/4'-DEMETHYLEPIPODOPHYLLOTOXINE/DMEP/4'-O-demethylepipodophyllotoxin/etoposide aglycone/4-Demethylepipodo phyllotoxin

IUPAC Name

(5S,5aR,8aR,9R)-5-hydroxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one

Density

1.4±0.1 g/cm3

Solubility

Methanol

Flash Point

224.4±25.0 °C

Boiling Point

626.5±55.0 °C at 760 mmHg

Melting Point

246-248ºC

InChl

InChl Key

YVCVYCSAAZQOJI-JHQYFNNDSA-N

WGK Germany

RID/ADR

HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:6559-91-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

No Article Available.


Description :

4'-Demethylepipodophyllotoxin(4'-DMEP) is a key intermediate compound for the preparation of podophyllotoxin-type anti-cancer drugs; a potent inhibitor of microtubule assembly.IC50 Value: 0.31uM(EC5 0in HL60 cell, MTT assay, 48h); 0.37uM(EC50 in HepG2 cell, MTT assay, 48h) [1]Target: microtubulein vitro: 4-TMP-DMEP showed strong cytotoxicity activity against the above-mentioned five tumor cell lines. The EC50s of 4-TMP-DMEP against these tumor cell lines ranged from 0.24 to 0.11 μM, which were 0.29 to 3618 times lower than that of DMEP [1].in vivo: Treatment of animals with DMEP (until the end of the experiment), 30 min before TPA treatment, significantly reduced the tumor incidence, tumor volume and the conversion efficiency of papillomas to squamous cell carcinomas. The tumor formation and growth was also delayed by DMEP pre-treatment [2].