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  • Brand : BIOFRON

  • Catalogue Number : BN-O1239

  • Specification : 98%(HPLC)

  • CAS number : 5355-16-8

  • Formula : C13H16N4O2

  • Molecular Weight : 260.29

  • PUBCHEM ID : 21453

  • Volume : 5mg

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Catalogue Number


Analysis Method





Molecular Weight



Botanical Source

Structure Type





Diaveridinum [INN-Latin]/Diaveridinum/DIAVERIDINE/2,4-Diamino-5-veratrylpyrimidine/5-(3,4-Dimethoxybenzyl)-2,4-pyrimidinediamine/2,4-diamino-5-(3,4-dimethoxy-benzyl)-pyrimidine/5-(3,4-dimethoxy-benzyl)-pyrimidine-2,4-diamine/5-[(3,4-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine/Diaveridin/BW 49-210/Diaveridina/5-Veratryl-pyrimidin-2,4-diyldiamin




1.3±0.1 g/cm3


Flash Point

259.9±32.9 °C

Boiling Point

506.1±60.0 °C at 760 mmHg

Melting Point

232 - 236ºC


InChl Key


WGK Germany


HS Code Reference

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:5355-16-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.




Comparative pharmacokinetic profiles of diaveridine following single intravenous and oral dose of 10 mg/kg body weight in healthy pigs and chickens were investigated, respectively. Concentrations of diaveridine in plasma samples were determined using a validated high-performance liquid chromatography-ultraviolet (HPLC-UV) method. The concentration-time data were subjected to noncompartmental kinetic analysis by WinNonlin program. The corresponding pharmacokinetic parameters in pigs or chickens after single intravenous administration were as follows, respectively: t1/2β (elimination half-life) 0.74 ± 0.28 and 3.44 ± 1.07 h; Vd (apparent volume of distribution) 2.70 ± 0.99 and 3.86 ± 0.92 L/kg; ClB (body clearance) 2.59 ± 0.62 and 0.80 ± 0.14 L/h/kg; and AUC0-∞ (area under the blood concentration vs. time curve) 4.11 ± 1.13 and 12.87 ± 2.60 μg∙h/mL. The corresponding pharmacokinetic parameters in pigs or chickens after oral administration were as follows, respectively: t1/2β 1.78 ± 0.41 and 2.91 ± 0.57 h; Cmax (maximum concentration) 0.43 ± 0.24 and 1.45 ± 0.57 μg/mL; Tmax (time to reach Cmax ) 1.04 ± 0.67 and 3.25 ± 0.71 h; and AUC0-∞ 1.33 ± 0.55 and 9.28 ± 2.69 μg∙h/mL. The oral bioavailability (F) of diaveridine in pigs or chickens was determined to be 34.6% and 72.2%, respectively. There were significant differences between the pharmacokinetics profiles in these two species.

© 2017 John Wiley & Sons Ltd.


Comparative Pharmacokinetics of Diaveridine in Pigs and Chickens Following Single Intravenous and Oral Administration


Y-F Li 1 2, H-Y Guo 2, F Yang 3, L-G Zhou 2, X-H Huang 2, H-Z Ding 2, Z-L Zeng 2

Publish date

2017 Oct




Diaveridine, a developed dihydrofolate reductase inhibitor, has been widely used as anticoccidial drug and antibacterial synergist. However, few studies have been performed to investigate its toxicity. To provide detailed toxicity with a wide spectrum of doses for diaveridine, acute and sub-chronic toxicity studies were conducted. Calculated LD50 was 2330 mg/kg b.w. in females and 3100 mg/kg b.w. in males, and chromodacryorrhea was noted in some females before their death. In the sub-chronic study, diaveridine was fed to Wistar rats during 90 days at dietary levels of 0, 23, 230, 1150 and 2000 mg/kg, which were about 0, 2.0-2.3, 21.0-23.5, 115.2-126.9 and 212.4-217.9 mg/kg b.w., respectively. Significant decrease in body weights in both genders at 1150 and 2000 mg/kg groups and significant increases in relative weights of brain in both genders, liver in females, kidneys and testis in males, alkaline phosphatase and potassium in both genders at 2000 mg/kg diet were noted. Significant decrease in absolute weights of several organs, hemoglobin and red blood cell count in both genders, albumin and total protein in females were observed at 2000 mg/kg diet. Fibroblasts in the kidneys, cell swelling of the glomerular zone in the adrenals and inflammation in the liver were found at 2000 mg/kg group. The no-observed-adverse-effect level of diaveridine was 230 mg/kg diet (21.0-23.5 mg/kg b.w./day).


Acute study; Diaminopyrimidines; Diaveridine; Sub-chronic study; Toxicity.


Acute and Sub-Chronic Toxicity Study of Diaveridine in Wistar Rats


Xu Wang 1, Shijia Su 1, Awais Ihsan 2, Qin Huang 3, Dongmei Chen 3, Guyue Cheng 3, Zhenli Liu 4, Yulian Wang 5, Zonghui Yuan 6

Publish date

2015 Oct;




This study developed and validated a simple and reliable method for detecting and quantifying DVD, TMP and OMP in feed using dichloromethane extraction followed by HPLC-MS/MS. A matrix effect evaluation was performed using the post-extraction spiking method, and levels were less than ±15% in all three feeds with their corresponding concentrations. LOD and LOQ, CCα and CCβ were 20μgkg(-1) and 40μgkg(-1), 8.68-15.55μgkg(-1) and 10.61-18.92μgkg(-1) for all analytes, respectively. Calibration curves were linear for DVD, TMP and OMP with R(2)⩾0.990 and r⩾0.995, respectively. Recoveries of low, medium and high concentrations using the proposed method ranged from 74.4 to 105.2%. Repeatability and within-laboratory reproducibility were <7.4% (RSD). The chosen seven factors had no a significant influence on robustness. The method showed good performance when it was applied to analyze other laboratory-prepared or actual feed samples.


Diaveridine; Feed; LC-MS/MS; Ormetoprim; Trimethoprim.


Simultaneous Determination of Diaveridine, Trimethoprim and Ormetoprim in Feed Using High Performance Liquid Chromatography Tandem Mass Spectrometry


Ya-Jun Yang 1, Xi-Wang Liu 1, Bing Li 1, Shi-Hong Li 1, Xiao-Jun Kong 1, Zhe Qin 1, Jian-Yong Li 2

Publish date

2016 Dec 1

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