We Offer Worldwide Shipping
Login Wishlist

didymin

$147

  • Brand : BIOFRON

  • Catalogue Number : BD-D1232

  • Specification : 98%(HPLC)

  • CAS number : 14259-47-3

  • Formula : C28H34O14

  • Molecular Weight : 594.56

  • PUBCHEM ID : 16760075

  • Volume : 20MG

Available on backorder

Quantity
Checkout Bulk Order?

Catalogue Number

BD-D1232

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

2-8°C

Molecular Weight

594.56

Appearance

White crystalline powder

Botanical Source

Melissa Officinalis; Clinopodium chinense (Benth.) O. Ktze./"Leaves of Monarda didyma (bergamot), from Acinos alpinus and Citrus spp."

Structure Type

Flavones/Flavanones

Category

Standards;Natural Pytochemical;API

SMILES

CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC=C(C=C5)OC)O)O)O)O)O)O)O

Synonyms

ISO-SAKURANETIN-7-RUTINOSIDE/6-O-(6-Desoxy-α-L-mannopyranosyl)-β-D-glucopyranoside de (2S)-5-hydroxy-2-(4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yle/4'-Methoxy-5,7-dihydroxyflavanone-7-o-rutinoside/Isosakuranetin-7-rutinoside/Iso-sakuranetin-7-putinoside/(2S)-5-Hydroxy-2-(4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl-6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside/(2S)-5-Hydroxy-2-(4-methoxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl]oxy}-2,3-dihydro-4H-chromen-4-on/(2S)-5-Hydroxy-2-(4-methoxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl]oxy}-2,3-dihydro-4H-chromen-4-one/(2S)-5-Hydroxy-2-(4-methoxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl]oxy}-2,3-dihydro-4H-chromen-4-one/4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-methoxyphenyl)-, (2S)-/ISOSAKURANETIN-7-O-RUTINOSIDE/(S)-7-((6-O-(6-Deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(4-methoxyphenyl)-4H-benzopyran-4-one/(S)-7-((6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(4-methoxyphenyl)-4H-benzopyran-4-one/(2S)-5-Hydroxy-2-(4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside/Neoponcirin/Isosakuranetin 7-O-rutinoside

IUPAC Name

(2S)-5-hydroxy-2-(4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one

Applications

Didymin, a dietary flavonoid glycoside from citrus fruits, possesses antioxidant properties. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma[1][2].

Density

1.6±0.1 g/cm3

Solubility

DMF

Flash Point

295.3±27.8 °C

Boiling Point

896.6±65.0 °C at 760 mmHg

Melting Point

211-213ºC

InChl

InChI=1S/C28H34O14/c1-11-21(31)23(33)25(35)27(39-11)38-10-19-22(32)24(34)26(36)28(42-19)40-14-7-15(29)20-16(30)9-17(41-18(20)8-14)12-3-5-13(37-2)6-4-12/h3-8,11,17,19,21-29,31-36H,9-10H2,1-2H3/t11-,17?,19+,21-,22+,23+,24-,25+,26+,27?,28+/m0/s1

InChl Key

RMCRQBAILCLJGU-CMTOHHPQSA-N

WGK Germany

RID/ADR

HS Code Reference

2938900000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:14259-47-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

PMID

26110393

Abstract

Flaxseed cake containing antioxidants is a valuable dietary component. Its nutritional effect may be diminished by the presence of anti-nutrients. The work was aimed at determining the effect of different contents of flaxseed cake in diets and their administration period on the development of rats and selected parameters of their health status. Diets with 15% and 30% addition of genetically modified (GM) flax seed cake with enhanced synthesis of polyphenols, as well as Linola non-GM flax were administered in short-term (33 days) and long-term (90 days) experiments. The 30% addition of flaxseed cake reduced digestibility of dietary nutrients, GM flaxseed cake lowered body weight gains. The relative weight of selected organs, hematological blood markers and serum activities of aspartate and alanine aminotransferases (AST, ALT) were not affected. Flaxseed cake consumption reduced serum concentration of albumins and increased globulins. Administration of 30% flaxseed cake improved plasma total antioxidant status and 30% GM flaxseed cake lowered liver thiobarbituric acid reactive substances. The activities of superoxide dismutase in erythrocytes, glutathione peroxidase in plasma and the liver concentration of 8-oxo-2′-deoxyguanosine were not changed. Most morphometric parameters of the small intestine did not differ between feeding groups. The administration of diets with 30% addition of flaxseed cake for 90 days improved the antioxidant status in rats.

KEYWORDS

GMO, flax, seed cake, polyphenols, flavonoids, SDG, safety, health, rat

Title

Effect of Dose and Administration Period of Seed Cake of Genetically Modified and Non-Modified Flax on Selected Antioxidative Activities in Rats

Author

Magdalena Matusiewicz,1,* Iwona Kosieradzka,1 Magdalena Zuk,2 and Jan Szopa2

Publish date

2015 Jun 23

PMID

19109507

Abstract

Inflammation is involved in some neurodegenerative disorders. NMDA glutamate receptors play an important role in neuronal development. Here, we show that NR1 expression in the cerebral cortex and primary neurons of rats was upregulated after lipopolysaccharide (LPS) treatment. This increase in NR1 expression was considered to be strongly associated with hypoxia-inducible factor-1α (HIF-1α) activation because the treatment of primary neurons with either echinomycin or small interfering RNA (siRNA) targeting HIF-1α could block NR1 expression. HIF-1α could be induced by an increase in the translational efficiency of the cells. After this, it was transported into the nucleus where it bound to the NR1 promoter and regulated the induction of NR1 transcriptional activity by LPS. LPS injection into the prefrontal cortex caused neuronal death, and this condition was aggravated by intracerebroventricular injection of echinomycin. Furthermore, knockdown of HIF-1α and NR1 by the appropriate siRNAs reduced the neurite outgrowth and viability of the primary neurons. These results suggest that NR1 expression is regulated by HIF-1α and plays a protective role in neurons during LPS challenge.

KEYWORDS

LPS, HIF-1, NR1, echinomycin, rpS6, cultured cortical neurons

Title

Hypoxia-Inducible Factor-1α Protects Cultured Cortical Neurons from Lipopolysaccharide-Induced Cell Death via Regulation of NR1 Expression

Author

Shiu-Hwa Yeh,1,3 Jan-Jong Hung,corresponding author1,2,3 Po-Wu Gean,1,3 and Wen-Chang Changcorresponding author1,2,3

Publish date

2008 Dec 24;

Abstract

Animals living in groups collectively produce social structure. In this context individuals make strategic decisions about when to cooperate and compete. This requires that individuals can perceive patterns in collective dynamics, but how this pattern extraction occurs is unclear. Our goal is to identify a model that extracts meaningful social patterns from a behavioral time series while remaining cognitively parsimonious by making the fewest demands on memory. Using fine-grained conflict data from macaques, we show that sparse coding, an important principle of neural compression, is an effective method for compressing collective behavior. The sparse code is shown to be efficient, predictive, and socially meaningful. In our monkey society, the sparse code of conflict is composed of related individuals, the policers, and the alpha female. Our results suggest that sparse coding is a natural technique for pattern extraction when cognitive constraints and small sample sizes limit the complexity of inferential models. Our approach highlights the need for cognitive experiments addressing how individuals perceive collective features of social organization.

KEYWORDS

cognition, statistical inference, collective computation, social complexity, social niche construction

Title

Sparse code of conflict in a primate society

Author

Bryan C. Daniels,a,b,1 David C. Krakauer,a,b and Jessica C. Flacka,b

Publish date

2012 Aug 13.