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Dihydrolycorine

$143

  • Brand : BIOFRON

  • Catalogue Number : BF-D2009

  • Specification : 98%

  • CAS number : 6271-21-2

  • Formula : C16H19NO4

  • Molecular Weight : 289.329

  • PUBCHEM ID : 11876135

  • Volume : 20mg

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Catalogue Number

BF-D2009

Analysis Method

HPLC,NMR,MS

Specification

98%

Storage

2-8°C

Molecular Weight

289.329

Appearance

Colorless column shaped crystal

Botanical Source

bulbus of Lycoris radiata (L. Herit.) Herb

Structure Type

Alkaloids

Category

Standards;Natural Pytochemical;API

SMILES

C1CN2CC3=CC4=C(C=C3C5C2C1CC(C5O)O)OCO4

Synonyms

(1S,2S,3aR,12bS,12cR)-2,3,3a,4,5,7,12b,12c-Octahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol/Dihydrolycorine/1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, 2,3,3a,4,5,7,12b,12c-octahydro-, (1S,2S,3aR,12bS,12cR)-

IUPAC Name

(1S,15R,17S,18S,19R)-5,7-dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9-triene-17,18-diol

Density

1.5±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

232.3±28.7 °C

Boiling Point

460.5±45.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C16H19NO4/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19/h4-5,8,11,14-16,18-19H,1-3,6-7H2/t8-,11+,14+,15-,16-/m1/s1

InChl Key

VJILFEGOWCJNIK-MGRBZGILSA-N

WGK Germany

RID/ADR

HS Code Reference

2938900000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:6271-21-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

PMID

8503287

Abstract

Dihydrolycorine-HCL(DL) is a derivative of lycorine, an alkaloid isolated from Lycoris radiata Herb. DL iv 20, 40, and 80 mg.kg-1 lowered the mean arterial pressure in pentobar-bitone-anesthetized normotensive rats, cats, and conscious rats either normotensive or renovascular hypertensive. In pithed rats DL depressed the hypertensive effect of reaction to electric stimulation to the T7-9 segments of spinal cord. DL also depressed the hypertensive effect of phenylephrine. In rabbit aorta ring and rat anococcygeus muscle, DL antagonized the contractile effect of methoxamine, with pA2 values of 5.93 and 6.35, respectively. These results suggest that DL can block alpha 1-adrenoceptors.

Title

[Hypotensive effect of dihydrolycorine].

Author

Chen BY1, Du ZH, Zeng FD, Hu CJ, Ma GE, Hong SH.

Publish date

1993 Jan

PMID

13465282

Title

The stereochemistry of dihydrolycorine.

Author

TAKEDA K, KOTERA K.

Publish date

1957 Jun

PMID

987194

Title

[Synthesis of dihydrolycorine].

Author

Irie H, Nishitani Y, Sugita M, Uyeo S.

Publish date

1976 May


Description :

Dihydrolycorine is isolated from Lycoris radiate Herb with antihypertensive and neuroprotective activities[1]. Dihydrolycorine is an inhibitor of protein synthesis in eukarytic cells by inhibiting the peptide bone formation step[2].