Synthesis of naturally occurring rubilactone, mollugin, and dihydromollugin of Rubia cordifolia PUMID/DOI：DOI: 10.1002/jccs.200100014 Rubilactone (1), dihydromollugin (2), and mollugin (3) are naturally occurring products found in Rubia cordifolia, which is a famous Chinese herb with antitumor, viral inhibition and other activities. Synthetic studies were carried out in these naphthoic acid esters starting from 1,4-dihydroxy-2-naphthoic acid. In this study, we finished the synthesis of rubilactone which has not been reported before and also synthesized dihydromollugin and mollugin with better yields with different approaches compared to those previously reported in the literature.
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
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provides coniferyl ferulate(CAS#:60657-93-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
Proceedings of the 3rd Biennial Conference of the Society for Implementation Research Collaboration (SIRC) 2015: advancing efficient methodologies through community partnerships and team science Seattle, WA, USA. 24-26 September 2015
Cara Lewis,corresponding author Doyanne Darnell, Suzanne Kerns, Maria Monroe-DeVita, Sara J. Landes, Aaron R. Lyon, Cameo Stanick, Shannon Dorsey, Jill Locke, Brigid Marriott, Ajeng Puspitasari, Caitlin Dorsey, Karin Hendricks, Andria Pierson, Phil Fizur, Katherine A. Comtois, Lawrence A. Palinkas,corresponding author Patricia Chamberlain,corresponding author Gregory A. Aarons,corresponding author Amy E. Green, Mark. G. Ehrhart, Elise M. Trott, Cathleen E. Willging, Maria E. Fernandez,corresponding author Nicholas H. Woolf, Shuting Lily Liang, Natalia I. Heredia, Michelle Kegler, Betsy Risendal, Andrea Dwyer, Vicki Young, Dayna Campbell, Michelle Carvalho, Yvonne Kellar-Guenther, Laura J. Damschroder,corresponding author Julie C. Lowery, Sarah S. Ono,corresponding author Kathleen F. Carlson, Erika K. Cottrell, Maya E. O’Neil, Travis L. Lovejoy, Joanna J. Arch,corresponding author Jill L. Mitchell, Cara C. Lewis,corresponding author Brigid R. Marriott, Kelli Scott, Jennifer Schurer Coldiron,corresponding author Eric J. Bruns, Alyssa N. Hook, Benjamin C. Graham,corresponding author Katelin Jordan, Rochelle F. Hanson,corresponding author Angela Moreland, Benjamin E. Saunders, Heidi S. Resnick, Shannon Wiltsey Stirman,corresponding author Cassidy A. Gutner, Jennifer Gamarra, Dawne Vogt, Michael Suvak, Jennifer Schuster Wachen, Katherine Dondanville, Jeffrey S. Yarvis, Jim Mintz, Alan L. Peterson, Elisa V. Borah, Brett T. Litz, Alma Molino, Stacey Young McCaughan, Patricia A. Resick, Nancy Pandhi,corresponding author Nora Jacobson, Neftali Serrano, Armando Hernandez, Elizabeth Zeidler- Schreiter, Natalie Wietfeldt, Zaher Karp, Michael D. Pullmann,corresponding author Barbara Lucenko, Bridget Pavelle, Jacqueline A. Uomoto, Andrea Negrete, Molly Cevasco, Suzanne E. U. Kerns, Robert P. Franks,corresponding author Christopher Bory, Edward J. Miech,corresponding author Teresa M. Damush, Jason Satterfield,corresponding author Derek Satre, Maria Wamsley, Patrick Yuan, Patricia O’Sullivan, Helen Best,corresponding author Susan Velasquez, Miya Barnett,corresponding author Lauren Brookman-Frazee, Jennifer Regan, Nicole Stadnick, Alison Hamilton, Anna Lau, Jennifer Regan,corresponding author Alison Hamilton, Nicole Stadnick, Miya Barnett, Anna Lau, Lauren Brookman-Frazee, Nicole Stadnick,corresponding author Anna Lau, Miya Barnett, Jennifer Regan, Scott Roesch, Lauren Brookman-Frazee, Byron J. Powell,corresponding author Thomas J. Waltz, Matthew J. Chinman, Laura Damschroder, Jeffrey L. Smith, Monica M. Matthieu, Enola K. Proctor, JoAnn E. Kirchner, Thomas J. Waltz,corresponding author Byron J. Powell, Matthew J. Chinman, Laura J. Damschroder, Jeffrey L. Smith, Monica J. Matthieu, Enola K. Proctor, JoAnn E. Kirchner, Monica M. Matthieu,corresponding author Craig S. Rosen, Thomas J. Waltz, Byron J. Powell, Matthew J. Chinman, Laura J. Damschroder, Jeffrey L. Smith, Enola K. Proctor, JoAnn E. Kirchner, Sarah C. Walker,corresponding author Asia S. Bishop, Mariko Lockhart, Allison L. Rodriguez,corresponding author Luisa Manfredi, Andrea Nevedal, Joel Rosenthal, Daniel M. Blonigen, Anne M. Mauricio,corresponding author Thomas D. Dishion, Jenna Rudo-Stern, Justin D. Smith, Jill Locke,corresponding author Courtney Benjamin Wolk, Colleen Harker, Anne Olsen, Travis Shingledecker, Frances Barg, David Mandell, Rinad S. Beidas, Marissa C. Hansen,corresponding author Maria P. Aranda, Isabel Torres-Vigil, Bryan Hartzler,corresponding author Bradley Steinfeld,corresponding author Tory Gildred, Zandrea Harlin, Fredric Shephard, Matthew S. Ditty,corresponding author Andrea Doyle, John A. Bickel, III, Katharine Cristaudo, Dan Fox,corresponding author Sonia Combs, David H. Lischner,corresponding author Richard A. Van Dorn, Stephen J. Tueller,corresponding author Jesse M. Hinde, Georgia T. Karuntzos, Maria Monroe-DeVita,corresponding author Roselyn Peterson, Doyanne Darnell, Lucy Berliner, Shannon Dorsey, Laura K. Murray, Yevgeny Botanov,corresponding author Beverly Kikuta, Tianying Chen, Marivi Navarro-Haro, Anthony DuBose, Kathryn E. Korslund, Marsha M. Linehan, Colleen M. Harker,corresponding author Elizabeth A. Karp, Sarah R. Edmunds, Lisa V. IbaNez, Wendy L. Stone, Jack H. Andrews,corresponding author Benjamin D. Johnides, Estee M. Hausman, Kristin M. Hawley, Beth Prusaczyk,corresponding author Alex Ramsey, Ana Baumann, Graham Colditz, Enola K. Proctor, Yevgeny Botanov,corresponding author Beverly Kikuta, Tianying Chen, Marivi Navarro-Haro, Anthony DuBose, Kathryn E. Korslund, Marsha M. Linehan, Colleen M. Harker,corresponding author Elizabeth A. Karp, Sarah R. Edmunds, Lisa V. IbaNez, Wendy L. Stone, Mimi Choy-Brown,corresponding author Jack H. Andrews,corresponding author Benjamin D. Johnides, Estee M. Hausman, Kristin M. Hawley, Beth Prusaczyk,corresponding author Alex Ramsey, Ana Baumann, Graham Colditz, Enola K. Proctor, Rosemary D. Meza,corresponding author Shannon Dorsey, Shannon Wiltsey-Stirman, Georganna Sedlar, Leah Lucid, Caitlin Dorsey,corresponding author Brigid Marriott, Nelson Zounlome, Cara Lewis, Cassidy A. Gutner,corresponding author Candice M. Monson, Norman Shields, Marta Mastlej, Meredith SH Landy, Jeanine Lane, Shannon Wiltsey Stirman, Natalie K. Finn,corresponding author Elisa M. Torres, Mark. G. Ehrhart, Gregory A. Aarons, Carol A. Malte,corresponding author Aline Lott, Andrew J. Saxon, Meredith Boyd,corresponding author Kelli Scott, Cara C. Lewis, Jennifer D. Pierce,corresponding author Agathe Lorthios-Guilledroit,corresponding author Lucie Richard, Johanne Filiatrault, Kevin Hallgren,corresponding author Shirley Crotwell, Rosa MuNoz, Becky Gius, Benjamin Ladd, Barbara McCrady, Elizabeth Epstein, John D. Clapp, Danielle E. Ruderman,corresponding author Melanie Barwick,corresponding author Raluca Barac, Stanley Zlotkin, Laila Salim, Marnie Davidson, Alicia C. Bunger,corresponding author Byron J. Powell, Hillary A. Robertson, Christopher Botsko,corresponding author Sara J. Landes,corresponding author Brandy N. Smith, Allison L. Rodriguez, Lindsay R. Trent, Monica M. Matthieu, Byron J. Powell,corresponding author Enola K. Proctor, Melanie S. Harned,corresponding author Marivi Navarro-Haro, Kathryn E. Korslund, Tianying Chen, Anthony DuBose, Andre Ivanoff, Marsha M. Linehan, Antonio R. Garcia,corresponding author Minseop Kim, Lawrence A. Palinkas, Lonnie Snowden, John Landsverk, Annika C. Sweetland,corresponding author Maria Jose Fernandes, Edilson Santos, Cristiane Duarte, Afranio Kritski, Noa Krawczyk, Caitlin Nelligan, Milton L. Wainberg, Gregory A. Aarons,corresponding author David H. Sommerfeld, Benjamin Chi, Echezona Ezeanolue, Rachel Sturke, Lydia Kline, Laura Guay, George Siberry, Ian M. Bennett,corresponding author Rinad Beidas, Rachel Gold, Johnny Mao, Diane Powers, Mindy Vredevoogd, Jurgen Unutzer, Jennifer Schroeder,corresponding author Lane Volpe, Julie Steffen, Shannon Dorsey,corresponding author Michael D Pullmann, Suzanne E. U. Kerns, Nathaniel Jungbluth, Lucy Berliner, Kelly Thompson, Eliza Segell, Pearl McGee-Vincent, Nancy Liu, Robyn Walser, Jennifer Runnals, R. Keith Shaw, Sara J. Landes,corresponding author Craig Rosen, Janet Schmidt, Patrick Calhoun, Ruth L. Varkovitzky,corresponding author Sara J. Landes, Amy Drahota,corresponding author Jonathan I. Martinez, Brigitte Brikho, Rosemary Meza, Aubyn C. Stahmer, Gregory A. Aarons, Anna Williamson,corresponding author Ronnie M. Rubin,corresponding author Byron J. Powell, Matthew O. Hurford, Shawna L. Weaver, Rinad S. Beidas, David S. Mandell, Arthur C. Evans, Byron J. Powell,corresponding author Rinad S. Beidas, Ronnie M. Rubin, Rebecca E. Stewart, Courtney Benjamin Wolk, Samantha L. Matlin, Shawna Weaver, Matthew O. Hurford, Arthur C. Evans, Trevor R. Hadley, David S. Mandell, Donald R. Gerke,corresponding author Beth Prusaczyk, Ana Baumann, Ericka M. Lewis, Enola K. Proctor, Jenna McWilliam,corresponding author Jacquie Brown, Michelle Tucker, Kathleen P Conte,corresponding author Aaron R. Lyon,corresponding author Meredith Boyd, Abigail Melvin, Cara C. Lewis, Freda Liu, Nathaniel Jungbluth, Amelia Kotte, Kaitlin A. Hill, Albert C. Mah, Priya A. Korathu-Larson, Janelle R. Au, Sonia Izmirian, Scott Keir, Brad J. Nakamura, Charmaine K. Higa-McMillan,corresponding author Brittany Rhoades Cooper,corresponding author Angie Funaiole, Eleanor Dizon, Eric J. Hawkins,corresponding author Carol A. Malte, Hildi J. Hagedorn, Douglas Berger, Anissa Frank, Aline Lott, Carol E. Achtmeyer, Anthony J. Mariano, Andrew J. Saxon, Kate Wolitzky-Taylor,corresponding author Richard Rawson, Richard Ries, Peter Roy-Byrne, Michelle Craske, Dena Simmons,corresponding author Catalina Torrente, Lori Nathanson, Grace Carroll, Justin D. Smith,corresponding author Kimbree Brown, Karina Ramos, Nicole Thornton, Thomas J. Dishion, Elizabeth A. Stormshak, Daniel S. Shaw, Melvin N. Wilson, Mimi Choy-Brown,corresponding author Emmy Tiderington, Bikki Tran Smith, Deborah K. Padgett, Ronnie M. Rubin,corresponding author Marilyn L. Ray, Abraham Wandersman, Andrea Lamont, Gordon Hannah, Kassandra A. Alia, Matthew O. Hurford, Arthur C. Evans, Lisa Saldana,corresponding author Holle Schaper, Mark Campbell, Patricia Chamberlain, Valerie B. Shapiro,corresponding author B.K. Elizabeth Kim, Jennifer L. Fleming, Paul A. LeBuffe, Sara J. Landes,corresponding author Cara C. Lewis, Allison L. Rodriguez, Brigid R. Marriott, Katherine Anne Comtois, Cara C. Lewis,corresponding author Cameo Stanick, Bryan J. Weiner, Heather Halko, and Caitlin Dorsey
Purpose:Preimplantation genetic diagnosis (PGD) is an important option for couples at risk of having children with β-globin mutations to avoid selective abortions of affected fetuses following prenatal diagnosis.
Methods:We performed PGD for thalassemia in 12 clinical cycles (IVS1-110, and IVS-745 mutations) using biopsy of the first and second polar bodies (PBs) extruded from oocytes during maturation and fertilization, coupled with nested polymerase chain reaction analysis and restriction digestion.
Results:A total of 118 oocytes was obtained, of which 78 had results for both the first and the second PBs. This resulted in the selection and transfer of 30 unaffected embryos (2.5 embryos per cycle). To avoid a possible misdiagnosis due to allele dropout (ADO), we have also introduced simultaneous detection of two highly polymorphic linked markers, a short tandem repeat immediately at the 5′ end of the globin gene and HUMTH01 which is a syntenic short tandem repeat. The application of multiplex polymerase chain reaction of the β-globin gene and linked polymorphic markers enabled detection of ADO in five first PBs, thus avoiding the transfer of potentially affected embryos resulting from their corresponding oocytes.
Conclusions:Confirmation studies of the embryos resulting from the oocytes predicted to contain an affected gene confirmed the diagnosis in 98% of the cases, thus demonstrating the accuracy and reliability of PB PGD of thalassemia mutations. The application of PB analysis in six patients resulted in two ongoing pregnancies with a thalassemia-free fetus already confirmed in both of them by prenatal diagnosis.
preimplantation genetic diagnosis, multiplex PCR, thalassemia, polymorphic markers, β-globin gene, allele dropout
Preimplantation Diagnosis of Thalassemias
A. Kuliev,corresponding author S. Rechitsky, O. Verlinsky, V. Ivakhnenko, S. Evsikov, G. Wolf, M. Angastiniotis, D. Georghiou, V. Kukharenko, C. Strom, and Y. Verlinsky
Purpose and Methods:We performed multiple comparisons between available amino acid (aa) sequences of homeodomain(HOM)-containing proteins from a wide spectrum of animals to create an evolutionary classification of the proteins.
Results:Based on results of statistical and special computational analyses of over 500 homeodomain aa sequences (HOMs) a novel system of concepts describing complex structural correlations between homologous proteins is proposed. This system includes such notions as differentiated isofunctionality of aa, chemotype, stereotype, local functional motifs, gradual conservativeness of aa positions, and group-specific domain patterns, as well as major categories of the evolutionary classification of HOMs (Division, Type, Branch, Class, Family, Series, Variety, Sort). Using this approach, a complete structural systematics of HOMs belonging to proteomes of eukaryotic animals is proposed.
Conclusions:The proposed structural classification of HOMs is in full agreement with the bulk of experimental data revealing complex functional similarities and differences among HOMs in terms of their expression patterns in developing embryos. It turn, this classification can provide answers regarding homology among homeodomains when experimental data are conflicting.
homeobox-containing genes, homeodomain-containing transcription factors, amino acid isofunctionality, homeodomain patterns, homeoprotein classification
Evolutionary Classification of Homeodomains
Viktor Gindilis,corresponding author Eugene Goltsman, and Yury Verlinsky