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Dihydropinosylvin methyl ether

$640

  • Brand : BIOFRON

  • Catalogue Number : BN-O1533

  • Specification : 98%(HPLC)

  • CAS number : 17635-59-5

  • Formula : C15H16O2

  • Molecular Weight : 228.3

  • PUBCHEM ID : 636980

  • Volume : 5mg

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Catalogue Number

BN-O1533

Analysis Method

HPLC,NMR,MS

Specification

98%(HPLC)

Storage

-20℃

Molecular Weight

228.3

Appearance

Powder

Botanical Source

This product is isolated and purified from the herbs of Pinus strobus

Structure Type

Phenols

Category

Standards;Natural Pytochemical;API

SMILES

COC1=CC(=CC(=C1)O)CCC2=CC=CC=C2

Synonyms

Dihydropinosylvin-monomethylether/3-O-Methyldihydropinosylvin/3-Methoxy-5-(2-phenylethyl)phenol/Phenol, 3-methoxy-5-(2-phenylethyl)-/3-Hydroxy-5-methoxybibenzyl/3-Hydroxy-5-methoxybibenzyl (3-Methoxy-5-(2-phenylethyl)phenol/Arbo 11/3-Methoxy-5-phenethyl-phenol/3-methoxy-5-phenethylphenol/5-Methoxy-bibenzyl-3-ol

IUPAC Name

3-methoxy-5-(2-phenylethyl)phenol

Density

1.1±0.1 g/cm3

Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

Flash Point

194.3±8.7 °C

Boiling Point

368.7±27.0 °C at 760 mmHg

Melting Point

InChl

InChI=1S/C15H16O2/c1-17-15-10-13(9-14(16)11-15)8-7-12-5-3-2-4-6-12/h2-6,9-11,16H,7-8H2,1H3

InChl Key

HPEFWCAKFRCLBD-UHFFFAOYSA-N

WGK Germany

RID/ADR

HS Code Reference

2909500000

Personal Projective Equipment

Correct Usage

For Reference Standard and R&D, Not for Human Use Directly.

Meta Tag

provides coniferyl ferulate(CAS#:17635-59-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate

No Technical Documents Available For This Product.

Title

WAO International Scientific Conference (WISC 2016) Abstracts Jerusalem, Israel. 6-9 December 2016

Author

Jun Bao,corresponding author1 Yi-Hui Wang,1 Quan-Hua Liu,1 Yi-Xiao Bao,1 Nurit Azouz,corresponding author2 Julie Caldwell,2 Leanne Ray,2 Mark Rochman,2 Melissa Mingler,2 Matthew Eilerman,2 Ting Wen,2 Jocelyn Biagini Myers,3 Gurjit Khurana Hershey,3 Leah Kottyan,4 Lisa Martin,4 Rothenberg Marc,2 Victor Gonzalez-Uribe,corresponding author5 Jaime Del Rio-Chivardi,6 Blanca Del Rio-Navarro,6 Hongfei Lou,corresponding author7 Siyuan Ma,7 Yan Zhao,8 Feifei Cao,9 Fei He,8 Zhongyan Liu,8 Chengshuo Wang,7 Claus Bachert,10 Luo Zhang,7 Elissa Abrams,corresponding author11 Allan Becker,11 Amit Kandhare,corresponding author12 Subhash Bodhankar,12 Nicole Grossman,corresponding author13 Gheorghe Doros,14 Francine Laden,15 Anne Fuhlbrigge,16 Michael Wechsler,17 Wilson Pace,18 Barbara Yawn,19 Elliot Israel,16 Junehyuk Lee,corresponding author20 Frederick Adler,21 Peter Kim,22 Yung Feng Huang,corresponding author23 Ying Yao Chen,23 Chiun Yen Pan,24 Herng Sheng Lee,25 Michael Khalemsky,corresponding author26 David G. Schwartz,26 Pavel Kolkhir,corresponding author27 Dmitry Pogorelov,27 Nikolay Kochergin,27 Hirsh Komarow,corresponding author28 Michael Young,29 Robin Eisch,28 Linda Scott,28 Dean Metcalfe,28 Alexander Singer,corresponding author30 Andrew Wakeman,31 Thomas Gerstner,32 Elissa Abrams,32 Woo-Jung Song,33 Ji-Su Shim,33 Ha-Kyeong Won,33 Sung-Yoon Kang,33 Kyoung-Hee Sohn,33 Byung-Keun Kim,33 Eun-Jung Jo,34 Min-Hye Kim,35 Sang-Heon Kim,36 Heung-Woo Park,33 Sun-Sin Kim,33 Yoon-Seok Chang,33 Alyn H. Morice,37 Byung-Jae Lee,38 Sang-Heon Cho,33 Kyung-Up Min,corresponding author33 Maria Assunta Boscolo,39 Giulio Brivio,39 Sergio Bosisio,39 Nicoletta Manzocchi,39 Edoardo Pulixi,39 Giulia Grignani,39 Eloisia D’Andrea,39 Massimo Ricci,39 Elena Passini,39 Maurizio Italia,39 Marilyn Urrutia-Pereira,corresponding author40 Stefani Fagundes,41 Vinicius Jardim Oliano,42 Dirceu Sole,43 Sadia Benzaquen,44 Alejandro Aragaki,44 Ricardo Balestra,44 Dawn Harden,44 Danielle Caudell-Stamper,44 Gilbert Glady,corresponding author45 Mark Holbreich,corresponding author46 Nataliya Lyakhovska,corresponding author47 Igor Kaidashev,47 Jaromir Bystron,48 Beata Hutyrova,48 Galina Balakirski,corresponding author49 Luk Vanstreels,49 Gerda Wurpts,49 Hans F. Merk,49 Jens Malte Baron,49 Johanna Plange,49 Hans-Peter Rihs,50 Monika Raulf,50 Stefani Roeseler,49 Alberto Tolcachier,corresponding author51 Armando Chamorro,52 Ruth Otero,52 Joel Brooks,corresponding author53 Michael Hess,54 Jared Benz,54 Joseph MacDonald,54 Joel Brooks,corresponding author55 Jared Benz,56 Usma Chatha,56 Dale Lent,56 Sukran Kose,corresponding author57 Bengu Gireniz Tatar,58 Gulgun Akkoclu,58 İbrahim cukurova,59 İlker odemiS,58 AySin Kılınc Toker,58 Abdullahi Hasssan,corresponding author60 Abdulrazaq Abdullahi Gobir,61 Cheol-Woo Kim,corresponding author62 Young Hwa Choi,63 Jeong Hye Lee,62 Rae Jeong Cho,62 Yu Ran Nam,64 Joo Hyun Nam,64 Woo Kyung Kim,corresponding author64 Ivana Filipovic,corresponding author65 Zorica Zivkovic,66 Djordje Filipovic,67 Dana Shik,corresponding author68 Andrew Smith,68 Wang Yui Hsi,68 Stuart Friedman,corresponding author69 Yonatan Gizaw,70 Rima Bakhda,70 Kumail Mohammed,70 Richard Wasserman,corresponding author71 Angela Hague,71 Deanna Pence,71 Joanna Rolen,71 Robert Sugerman,71 Stacy Silvers,71 Qurat Kamili,72 Nadezhda Knauer,corresponding author73 Alexandr Zazernyi,74 Elena Blinova,73 Daria Demina,75 Vladimir Kozlov,73 Komal Agrawal,corresponding author76 Sagar Kale,76 Naveen Arora,76 Volha Vasilkova,77 Tatiana Mokhort,78 William Silvers,corresponding author79 Rachel Eisenberg,corresponding author80 Rushita Mehta,80 Arye Rubinstein,80 Antony Aston,corresponding author81 Paul Turner,81 Monica Ruiz-Garcia,81 Robert Boyle,81 Simon Brown,82 Yael Dinur Schejter,corresponding author83 Adi Ovadia,83 Vy Kim,83 Brenda Reid,83 Chaim Roifman,83 Lana Rosenfield,corresponding author84 Ernie Avilla,85 Laurie Harada,86 Marilyn Allen,86 Susan Waserman,84 Ho Joo Yoon,corresponding author87 Gun Woo Koo,87 Suk-Il Chang,88 Hye-Ran Yoon,89 Dong Won Park,87 Tai Sun Park,87 Ji-Yong Moon,87 Sang-Heon Kim,87 Tae Hyung Kim,87 Jang Won Sohn,87 Dong Ho Shin,87 Tsici Jorjoliani,corresponding author90 Lia Jorjoliani,91 Nino Adamia,92 Nona katamadze,90 Deepika Ramachandra,corresponding author93 Liana Jorjoliani,corresponding author94 Rusudan Karseladze,94 Lali Saginadze,94 Nino Adamia,94 Natalia Chkuaseli,94 Anna Dolgova,corresponding author95 Olga Stukolova,95 Anna Sudina,95 Anna Cherkashina,95 German Shipulin,95 Giulio Brivio,corresponding author96 Maria Assunta Boscolo,96 Richard Rosenthal,corresponding author97 Harvey Howe,98 Paul Knause,98 Rony Greemberg,99 Jean Jacques De Bruycker,99 Isabel Fernandez,99 Francoise Le Deist,99 Elie Haddad,99 Yeong Ho Rha,corresponding author100 Kyung Suk Lee,101 Sun Hee Choi,100 Herman Tam,corresponding author102 Estelle Simons,102 Elinor Simons,102 Maria Golebiowska-Wawrzyniak,103 Katarzyna Markiewicz,103 Yoram Faitelson,corresponding author104 Miguel Stein,104 Avigdor Mandelberg,105 Ilan Dalal,104 Michael Levin,corresponding author106 Lelani Hobane,107 Wisdom Basera,107 Maresa Botha,106 Claudia Gray,106 Heather Zar,108 Biserka Jovkovska Kjaeva,corresponding author109 Zoran Arsovski,110 Vesna Grivcheva-Panovska,corresponding author111 Adeyinka Odebode,corresponding author112 Adedotun Adekunle,112 Peter Adeonipekun,112 Ebenezer Farombi,113 Nadezhda Camacho-OrdoNez,114 Alejandrina Josefina Martinez-Vazquez,115 Maria de la Luz H. Garcia-Cruz,corresponding author116 Qi Tan,corresponding author117 Rui Min,117 Guan-qun Dai,117 Wei-Ping Xie,117 Huang Mao,117 Hong Wang,117 Rakesh Yadav,corresponding author118 Sneha Singh,118 Divya Yadav,118 Ekaterina Khaleva,corresponding author119 Henry T. Bahnson,120 Amber Franz,121 Lene Heise Garvey,122 Nicola Jay,123 Rubaiyat Haque,124 Adam Fox,119 Gideon Lack,119 George du Toit,119 Snezana Radic,corresponding author125 Branislava Milenkovic,126 Ana Neskovic,125 Ljiljana Danojevic,127 Liat Nachshon,corresponding author128 Michael Goldberg,128 Michael Levy,128 Yitzhak Katz,128 Arnon Elizur,128 Cristine Rosario,corresponding author129 Juliana Kasper,129 Herbeto Chong-Neto,129 Carlos Riedi,129 Nelson Rosario,129 Arnon Elizur,corresponding author130 Michael B. Levy,130 Ronly Har-Even,130 Liat Nachshon,130 Mor Carmel,130 Michael R. Goldberg,130 Maia Kherkheulidze,corresponding author131 Nani Kavlashvili,131 Eka Kandelaki,131 Nino Adamai,132 Maia Kherkheulidze,corresponding author132 Lia Jorjoliani,132 Irma Ubiria,132 Andrea Burke,corresponding author133 Ernie Avilla,134 Monika Kastner,135 Susan Waserman,133 Denica Zheleva,corresponding author136 Razvigor Darlenski,136 Konstantinos Bozinakis,137 Anastasios Kriebardis,138 Sofia Styliara,137 Aikaterini Karastathi,137 Nikolaos Farmakas,corresponding author137 Maria Luiza Kraft Kohler Ribeiro,139 Ana Carolina Barcellos,140 Hannah Gabriele Ferreira Silva,140 Luis Henrique Mattei Carletto,140 Marcela Carolina Bet,140 Nathalia Zorze Rossetto,140 Nelson Augusto Rosario,140 Herberto Jose Chong-Neto,corresponding author140 Fernanda Valenca,141 Marina Novaes,corresponding author141 Mariana Gomes,141 Carla Seifert,141 Alfredo Neto,141 Flavia Loyola,141 Jose Rios,141 Tatiana Silva,141 Aline Neves,corresponding author142 Marina Novaes,142 Fernanda Valenca,142 Mariana Gomes,142 Alfredo Neto,142 Flavia Loyola,142 Jose Rios,142 Oznur Abadoglu,corresponding author143 Bilun Gemicioglu,144 Hasan Bayram,145 Arif Cimrin,146 Levent Akyildiz,147 Aykut Cilli,148 Hakan Gunen,149 Tevfik Ozlu,150 Mecit Suerdem,151 Esra Uzaslan,152 Zeynep Misirligil,153 Branislava Milenkovic,corresponding author154 Snezana Radic,155 Snezana Ristic-Stojanovic,156 A. Milicevic,156 A. Milenkovic,156 Jelena Cvejic,154 Jelena Jankovic,154 Sanja Dimic-Janjic,154 Natasa Djurdjevic,154 Vladyslava Barzylovych,corresponding author157 Tetiana Umanets,158 Anastasia Barzylovych,159 Karyn Winkler,corresponding author160,161 Jessica Margarinos,162 Dylan Martin,162 Maja Nowakowski,160,163 Rauno Joks,160,164 Miguel Stein,corresponding author165 Tsili Zangen,166 Olga Bernadsky,167 Mona Boaz,168 Gratiana Hermann,169 Yoram Faitelson,165 Ilan Dalal,165 Rachel Aviv,165 Olga Kuperboim,165 Larisa Ramichanov,165 Efrat Broide,170 Raanan Shamir,171 Noam Zevit,171 Ron Shaoul,172 Alex Fich,173 Arie Levine,166 Adi Ovadia,corresponding author174 Yael Dinur Schejter,174 Chaim Roifman,174 Isaac Melamed,corresponding author175 Roopesh Singh Gangwar,corresponding author176 Yael Minai-Fleminger,176 Mansour Seaf,176 Amichai Gutgold,176 Aarti Shikotra,177 Anoop Chauhan,178 Stephen Holgate,179 Peter Bradding,177 Peter Howarth,179 Ron Eliashar,180 Neville Berkman,181 Francesca Levi-Schaffer,176 Sung-il Woo,corresponding author182 Betul Celik,183 Tangul Bulut,183 Arzu Didem Yalcin,corresponding author184 Betul Celik,185 Arzu Didem Yalcin,corresponding author186 Tangul Bulut,185 Luiz Querino Caldas,corresponding author187 Ronit Confino-Cohen,188 Yossi Rosman,corresponding author188 Arnon Goldberg,188 Oded Breuer,corresponding author189 Roopesh Singh,190 Mansour Seaf,190 Ahlam Barhoum,190 Eitan Kerem,189 Francesca Levi-Schaffer,190 Tatiana Slavyanskaya,191 Revaz Sepiashvili,corresponding author191 Elena A. Blinova,corresponding author192 Ekaterina A. Pashkina,192 Marina I. Leonova,193 Vera M. Nepomnyaschikh,193 Darya V. Demina,193 Vladimir A. Kozlov,192 Revital Shamri,corresponding author194 Kristen M. Young,195 Peter F. Weller,195 Rodolfo de Paula Vieira,corresponding author196 Manoel Carneiro Oliveira-Junior,196 Nilsa Regina Damasceno-Rodrigues,197 Fernanda Magalhães Arantes-Costa,198 Milton Arruda Martins,198 Ana Paula Ligeiro Oliveira,196 Alfred Bernard,corresponding author199 Antonia Sardella,199 Catherine Voisin,199 Simon Royce,corresponding author200 Hamish Philpott,201 Sanjay Nandurkar,202 Francis Thien,203 Peter Gibson,201 Rodolfo Bianchini,204 Franziska Roth-Walter,204 Anna Ohradanova-Repic,205 Gerlinde Hofstetter,204 Ina Herrmann,206 Maria Isabel Carvalho,207 Karin Hufnagl,204 Erika Bajna,208 Georg Roth,209 Hannes Stockinger,205 Erika Jensen-Jarolim,corresponding author208 Meital Almog,corresponding author210 Aharon Kessel,210 Larisa Apov,211 Carlos Sanchez Salguero,corresponding author212 Alvaro Sanchez Chacon,212 Abbos Nazarov,corresponding author213 Shaxbos Ergashev,214 Irina Nesterova,corresponding author215 Svetlana Kovaleva,215 Galina Chudilova,215 Ludmila Lomtatidze,215 Sarah De Schryver,216 Alizee Dery,217 Ann Clarke,218 Kari Nadeau,219 Laurie Harada,220 Kimberly Weatherall,221 Celia Greenwood,222 Denise Daley,223 Yuka Asai,224 Moshe Ben-Shoshan,corresponding author216 Irina Balmasova,corresponding author225 Elena Malova,225 Karin Hufnagl,226 Stefanie Wagner,226 Luis F. Pacios,227 Michael Wallner,228 Markus Wiederstein,228 Gerlinde Hofstetter,226 Franziska Roth-Walter,226 Erika Jensen-Jarolim,corresponding author229 Anna E. Tevs,corresponding author230 Ekaterina A. Pashkina,231 Marina I. Leonova,230 Vera M. Nepomnyaschikh,230 Darya V. Demina,230 Vladimir A. Kozlov,231 Elena A. Blinova,231 Nataly Tataurshchikova,corresponding author232 Baigalmaa Sangidorj,232 Anna Ronzhina,232 Revaz Sepiashvili,corresponding author233 Tatiana Slavyanskaya,233 Manana Chikhladze,234 Oliver F. Wirz,corresponding author235 Willem van de Veen,235 David Mirer,235 Hideaki Morita,236 Can Altunbulakli,235 Sebastian L. Johnston,237 Nicholas Glanville,237 Nikolaos G. Papadopoulos,238 Cezmi A. Akdis,235 Mubeccel Akdis,241 Avner Reshef,corresponding author239 Marc Riedl,240 Vesna Grivcheva Panovska,243 Dumitru Moldovan,242 James Baker,244 William H. Yang,246 Sladjana Andrejevic,245 Richard F. Lockey,248 Roman Hakl,247 Shmuel Kivity,250 Luca Bellizzi,251 Joseph R. Harper,252 Anurag Relan,249 and Marco Cicardi253

Publish date

2017;

PMID

27053235

Abstract

Aims/hypothesis
Type 1 diabetes results from T cell mediated destruction of beta cells. We conducted a trial of antithymocyte globulin (ATG) in new-onset type 1 diabetes (the Study of Thymoglobulin to ARrest T1D [START] trial). Our goal was to evaluate the longer-term safety and efficacy of ATG in preserving islet function at 2 years.

Methods
A multicentre, randomised, double-blind, placebo-controlled trial of 6.5 mg/kg ATG (Thymoglobulin) vs placebo in patients with new-onset type 1 diabetes was conducted at seven university medical centres and one Children’s Hospital in the USA. The site-stratified randomisation scheme was computer generated at the data coordinating centre using permuted-blocks of size 3 or 6. Eligible participants were between the ages of 12 and 35, and enrolled within 100 days from diagnosis. Subjects were randomised to 6.5 mg/kg ATG (thymoglobulin) vs placebo in a 2:1 ratio. Participants were blinded, and the study design included two sequential patient-care teams: an unblinded study-drug administration team (for the first 8 weeks), and a blinded diabetes management team (for the remainder of the study). Endpoints assessed at 24 months included meal-stimulated C-peptide AUC, safety and immunological responses.

Results
Fifty-eight patients were enrolled; at 2 years, 35 assigned to ATG and 16 to placebo completed the study. The pre-specified endpoints were not met. In post hoc analyses, older patients (age 22-35 years) in the ATG group had significantly greater C-peptide AUCs at 24 months than placebo patients. Using complete preservation of baseline C-peptide at 24 months as threshold, nine of 35 ATG-treated participants (vs 2/16 placebo participants) were classified as responders; nine of 11 responders (67%) were older. All participants reported at least one adverse event (AE), with 1,148 events in the 38 ATG participants vs 415 in the 20 placebo participants; a comparable number of infections were noted in the ATG and placebo groups, with no opportunistic infections nor difficulty clearing infections in either group. Circulating T cell subsets depleted by ATG partially reconstituted, but regulatory, naive and central memory subsets remained significantly depleted at 24 months. Beta cell autoantibodies did not change over the 24 months in the ATG-treated or placebo participants. At 12 months, ATG-treated participants had similar humoral immune responses to tetanus and HepA vaccines as placebo-treated participants, and no increased infections.

Conclusions/interpretation
A brief course of ATG substantially depleted T cell subsets, including regulatory cells, but did not preserve islet function 24 months later in the majority of patients with new-onset type 1 diabetes. ATG preserved C-peptide secretion in older participants, which may warrant further study.

Trial registration:
ClinicalTrials.gov NCT00515099

Public data repository:
START datasets are available in TrialShare www.itntrialshare.org

Funding:
National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH). The trial was conducted by the Immune Tolerance Network (ITN).

Electronic supplementary material
The online version of this article (doi:10.1007/s00125-016-3917-4) contains peer-reviewed but unedited supplementary material, which is available to authorised users.

KEYWORDS

ATG, Beta cells, C-peptide, START trial, T cells, Thymoglobulin, Tregs, Type 1 diabetes

Title

Antithymocyte globulin therapy for patients with recent-onset type 1 diabetes: 2 year results of a randomised trial

Author

Stephen E. Gitelman,corresponding author1,2 Peter A. Gottlieb,3 Eric I. Felner,4 Steven M. Willi,5,6 Lynda K. Fisher,7 Antoinette Moran,8 Michael Gottschalk,9 Wayne V. Moore,10 Ashley Pinckney,11 Lynette Keyes-Elstein,11 Kristina M. Harris,12 Sai Kanaparthi,12 Deborah Phippard,12,13 Linna Ding,14 Jeffrey A. Bluestone,2 Mario R. Ehlers,15 and the ITN START Study Team

Publish date

2016;

PMID

31999282

Abstract

Measurements of the associated production of a Z boson with at least one jet originating from a b quark in proton-proton collisions at s=8TeV are presented. Differential cross sections are measured with data collected by the CMS experiment corresponding to an integrated luminosity of 19.8fb-1. Z bosons are reconstructed through their decays to electrons and muons. Cross sections are measured as a function of observables characterizing the kinematics of the b jet and the Z boson. Ratios of differential cross sections for the associated production with at least one b jet to the associated production with any jet are also presented. The production of a Z boson with at least two b jets is investigated, and differential cross sections are measured for the dijet system. Results are compared to theoretical predictions, testing two different flavour schemes for the choice of initial-state partons.

Title

Measurements of the associated production of a Z boson and b jets in pp collisions at s=8TeV

Publish date

2017;


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