This product is isolated and purified from the herbs of Dioscorea rotundata
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
366.0±17.0 °C at 760 mmHg
HS Code Reference
Personal Projective Equipment
For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:14531-52-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
New peptides with potential antimicrobial activity, encrypted in milk protein sequences, were searched for with the use of bioinformatic tools. The major milk proteins were hydrolyzed in silico by 28 enzymes. The obtained peptides were characterized by the following parameters: molecular weight, isoelectric point, composition and number of amino acid residues, net charge at pH 7.0, aliphatic index, instability index, Boman index, and GRAVY index, and compared with those calculated for known 416 antimicrobial peptides including 59 antimicrobial peptides (AMPs) from milk proteins listed in the BIOPEP database. A simple analysis of physico-chemical properties and the values of biological activity indicators were insufficient to select potentially antimicrobial peptides released in silico from milk proteins by proteolytic enzymes. The final selection was made based on the results of multidimensional statistical analysis such as support vector machines (SVM), random forest (RF), artificial neural networks (ANN) and discriminant analysis (DA) available in the Collection of Anti-Microbial Peptides (CAMP database). Eleven new peptides with potential antimicrobial activity were selected from all peptides released during in silico proteolysis of milk proteins.
milk proteins, in silico proteolysis, antimicrobial peptides, bioinformatics
New Milk Protein-Derived Peptides with Potential Antimicrobial Activity: An Approach Based on Bioinformatic Studies
Bartłomiej Dziuba1,* and Marta Dziuba2
Attempted RCM of 2,2′-bis(allyloxy)-1,1′-binaphthyl resulted in a Claisen-type rearrangement of a postulated labile dioxacyclodecine proceeding at room temperature and followed by [2+2] cycloaddition. Structures of products were confirmed by X-ray crystallography. A mechanistic rationalisation based on relative stabilities of proposed intermediates and transition states is provided.
DFT calculations, Grubbs II catalyst, cage compounds, spiro-compounds, chiral macrocycle
Tandem RCM-Claisen Rearrangement-[2+2] Cycloaddition of O,O'-(But-2-en-1,4-diyl)-bridged Binaphthols
Michael Abraham,1 Wolfgang Reischl,1 Karl A. Kirchner,2 Alexander Roller,3 Luis F. Veiros,4 and Michael Widhalm1,*
Ion signals are critical to regulating polarized growth in many cell types, including pollen in plants and neurons in animals. Genetic evidence presented here indicates that pollen tube growth requires cyclic nucleotide-gated channel (CNGC) 18. CNGCs are nonspecific cation channels found in plants and animals and have well established functions in excitatory signal transduction events in animals. In Arabidopsis, male sterility was observed for two cngc18 null mutations. CNGC18 is expressed primarily in pollen, as indicated from a promoter::GUS (β-glucuronidase) reporter analysis and expression profiling. The underlying cause of sterility was identified as a defect in pollen tube growth, resulting in tubes that were kinky, short, often thin, and unable to grow into the transmitting tract. Expression of a GFP-tagged CNGC18 in mutant pollen provided complementation and evidence for asymmetric localization of CNGC18 to the plasma membrane at the growing tip, starting at the time of pollen grain germination. Heterologous expression of CNGC18 in Escherichia coli resulted in a time- and concentration-dependent accumulation of more Ca2+. Thus, CNGC18 provides a mechanism to directly transduce a cyclic nucleotide (cNMP) signal into an ion flux that can produce a localized signal capable of regulating the pollen tip-growth machinery. These results identify a CNGC that is essential to an organism’s life cycle and raise the possibility that CNGCs have a widespread role in regulating cell-growth dynamics in both plant and animals.
calcium, male sterile, Arabidopsis, CaM
A cyclic nucleotide-gated channel is essential for polarized tip growth of pollen
Sabine Frietsch, Yong-Fei Wang, Chris Sladek, Lisbeth R. Poulsen, Shawn M. Romanowsky, Julian I. Schroeder, Jeffrey F. Harper
2007 Sep 4;